Nagaoka H., Muramatsu M., Yamamura N., Kinoshita K., Honjo T.

J. Exp. Med. 195:529-534(2002) GeneRIF 11628 · Mapped (13)
B cell stimulation which induces class switch recombination (CSR) but not somatic hypermutation (SHM) leads to AID-dependent accumulation of SHM-like point mutations in the switch mu region uncoupled with CSR GeneRIF 11628

Okazaki I.M., Kinoshita K., Muramatsu M., Yoshikawa K., Honjo T.

Nature 416:340-345(2002) GeneRIF 11628 · Mapped (13)
ectopic expression of AID induces CSR in an artificial switch construct in fibroblasts at a level comparable to that in stimulated B cells GeneRIF 11628

Papavasiliou F.N., Schatz D.G.

J. Exp. Med. 195:1193-1198(2002) GeneRIF 11628 · Mapped (13)
activation-induced deaminase fuels two distinct molecular modifications of Ig genes. GeneRIF 11628

Yoshikawa K., Okazaki I.M., Eto T., Kinoshita K., Muramatsu M., Nagaoka H., Honjo T.

Science 296:2033-2036(2002) GeneRIF 11628 MGI 1342279 · Mapped (13)
results indicate that AID is sufficient for the generation of somatic hypermutation (SHM) in an actively transcribed gene in fibroblasts as well as B cells and that any of the required cofactors must be present in these fibroblasts GeneRIF 11628

Fagarasan S., Muramatsu M., Suzuki K., Nagaoka H., Hiai H., Honjo T.

Science 298:1424-1427(2002) GeneRIF 11628 · Mapped (13)
deficiency in AID results in the development of hyperplasia of isolated lymphoid follicles (ILFs) associated with a 100-fold expansion of anaerobic flora in the small intestine GeneRIF 11628

Doi T., Kinoshita K., Ikegawa M., Muramatsu M., Honjo T.

Proc. Natl. Acad. Sci. U.S.A. 100:2634-2638(2003) GeneRIF 11628 · Mapped (13)
AID has a role in RNA-editing and de novo protein synthesis is required for in class-switch recombination GeneRIF 11628

Sayegh C.E., Quong M.W., Agata Y., Murre C.

Nat. Immunol. 4:586-593(2003) GeneRIF 11628 · Mapped (16)
Expression of E47 activates aicda expression. GeneRIF 11628

Okazaki I.M., Hiai H., Kakazu N., Yamada S., Muramatsu M., Kinoshita K., Honjo T.

J. Exp. Med. 197:1173-1181(2003) GeneRIF 11628 · Mapped (13)
expression leads to tumorigenesis GeneRIF 11628

Barreto V., Reina-San-Martin B., Ramiro A.R., McBride K.M., Nussenzweig M.C.

Mol. Cell 12:501-508(2003) GeneRIF 11628 · Mapped (34)
there is an essential role for the C-terminal domain of AID in CSR that is independent of its cytidine deaminase activity and that is not required for either gene conversion or somatic hypermutation GeneRIF 11628

Gonda H., Sugai M., Nambu Y., Katakai T., Agata Y., Mori K.J., Yokota Y., Shimizu A.

J. Exp. Med. 198:1427-1437(2003) GeneRIF 11628 · Mapped (16)
effect of Pax5 and Id2 on gene expression GeneRIF 11628

Nambu Y., Sugai M., Gonda H., Lee C.G., Katakai T., Agata Y., Yokota Y., Shimizu A.

Science 302:2137-2140(2003) GeneRIF 11628 · Mapped (13)
data indicate an important role of germline transcription in the regulation of chromatin accessibility strongly suggesting the target of AID is chromatin DNA; results give insights on the role of AID and regulatory mechanism of class switch recombination GeneRIF 11628

Frasca D., Van der Put E., Riley R.L., Blomberg B.B.

J. Immunol. 172:2155-2162(2004) GeneRIF 11628 · Mapped (16)
Impaired induction of activation-induced cytidine deaminase contributes to poor class switch recombination and production of secondary isotypes in senescence. GeneRIF 11628

Bross L., Jacobs H.

Clin. Dev. Immunol. 10:83-89(2003) GeneRIF 11628 · Mapped (13)
Aicda acts downstream of the DNA lesions to mediate error prone processing GeneRIF 11628

Shinkura R., Ito S., Begum N.A., Nagaoka H., Muramatsu M., Kinoshita K., Sakakibara Y., Hijikata H., Honjo T.

Nat. Immunol. 5:707-712(2004) GeneRIF 11628 MGI 1342279 · Mapped (34)
separate domains of AID interact with specific cofactors to regulate these two distinct genetic events in a target-specific way GeneRIF 11628

Chaudhuri J., Khuong C., Alt F.W.

Nature 430:992-998(2004) GeneRIF 11628 · Mapped (15)
proposal that B-cell-specific AID-Replication Protein A complexes preferentially bind to ssDNA of small transcription bubbles at SHM 'hotspots' leading to AID-mediated deamination and RPA-mediated recruitment of DNA repair proteins GeneRIF 11628

Krause K., Marcu K.B., Greeve J.

Mol. Immunol. 43:295-307(2006) GeneRIF 11628 MGI 1342279 · Mapped (17)
Editing by AID was studied in yeast using Gal4 linked to Gal80 via an apo B cassette (Gal4-C) or via a mouse Ig heavy chain gene variable region (Gal4-VH). AID did not edit either form but induced plasmid recombination with no target specificity. GeneRIF 11628

Rush J.S., Liu M., Odegard V.H., Unniraman S., Schatz D.G.

Proc. Natl. Acad. Sci. U.S.A. 102:13242-13247(2005) GeneRIF 11628 · Mapped (13)
the regulation of Aicda expression was division-linked and independent of time; constitutive Aicda expression from a transgene accelerated division-linked class switch recombination GeneRIF 11628

Basu U., Chaudhuri J., Alpert C., Dutt S., Ranganath S., Li G., Schrum J.P., Manis J.P., Alt F.W.

Nature 438:508-511(2005) GeneRIF 11628 · Mapped (13)
PKA has a critical role in post-translational regulation of AID activity in B cells GeneRIF 11628

Ramiro A.R., Jankovic M., Callen E., Difilippantonio S., Chen H.T., McBride K.M., Eisenreich T.R., Chen J., Dickins R.A., Lowe S.W. et al.

Nature 440:105-109(2006) GeneRIF 11628 MGI 1342279 · Mapped (87)
translocations between c-myc and the IgH locus (Igh) are induced in primary B cells within hours of expression of the catalytically active form of activation-induced cytidine deaminase (AID) GeneRIF 11628

McBride K.M., Gazumyan A., Woo E.M., Barreto V.M., Robbiani D.F., Chait B.T., Nussenzweig M.C.

Proc. Natl. Acad. Sci. U.S.A. 103:8798-8803(2006) GeneRIF 11628 · Mapped (13)
A small fraction of AID is phosphorylated in activated B cells and that the modified form contributes disproportionately to hypermutation. GeneRIF 11628

Gourzi P., Leonova T., Papavasiliou F.N.

Immunity 24:779-786(2006) GeneRIF 11628 MGI 1342279 · Mapped (13)
AID is active in innate defense against a transforming retrovirus. GeneRIF 11628

Rucci F., Cattaneo L., Marrella V., Sacco M.G., Sobacchi C., Lucchini F., Nicola S., Della Bella S., Villa M.L., Imberti L. et al.

Gene 377:150-158(2006) GeneRIF 11628 · Mapped (13)
additional factors present in thymocytes but not in other tissues or in lymphoid cells at different stages of differentiation are needed for AID to fully manifest its tumorigenic potential GeneRIF 11628

Xue K., Rada C., Neuberger M.S.

J. Exp. Med. 203:2085-2094(2006) GeneRIF 11628 · Mapped (19)
Data suggest that in the absence of uracil-DNA glycosylase and MutS-2 activation-induced deaminase may act at the mu switch region but there is no preference for targeting of the transcribed versus nontranscribed strand. GeneRIF 11628

Shen H.M., Tanaka A., Bozek G., Nicolae D., Storb U.

J. Immunol. 177:5386-5392(2006) GeneRIF 11628 · Mapped (21)
in Msh6(-/-)Ung(-/-) mice the 5' end and the 3' region of Ig genes was spared from mutations as in wild-type mice confirming that AID does not act in these regions GeneRIF 11628

Hsu H.C., Wu Y., Yang P., Wu Q., Job G., Chen J., Wang J., Accavitti-Loper M.A., Grizzle W.E., Carter R.H. et al.

J. Immunol. 178:5357-5365(2007) GeneRIF 11628 · Mapped (13)
AID expression in B cells is a promising therapeutic target for the treatment of autoimmune diseases and that suppression of this gene may be a molecular target of CTLA4-Ig therapy. GeneRIF 11628