uniprot:Q9WU20 in citationmapping

1 - 25 of 37 results for uniprot:Q9WU20 in citationmapping

Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. Tran P., Leclerc D., Chan M., Pai A., Hiou-Tim F., Wu Q., Goyette P., Artigas C., Milos R., Rozen R. Mamm. Genome 13:483-492(2002) GeneRIF 17769 MGI 106639 · UniProtKB (15) · Mapped (14) multiple transcription start sites and alternative splicing GeneRIF 17769
Characterization of a pseudogene for murine methylenetetrahydrofolate reductase. Leclerc D., Darwich-Codore H., Rozen R. Mol. Cell. Biochem. 252:391-395(2003) GeneRIF 17769 MGI 106639 · Mapped (13) reduces 5 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate the major carbon donor in the remethylation of homocysteine to methionine GeneRIF 17769
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Devlin A.M., Arning E., Bottiglieri T., Faraci F.M., Rozen R., Lentz S.R. Blood 103:2624-2629(2004) GeneRIF 17769 MGI 106639 · Mapped (13) Mthfr(+/-) genotype sensitizes mice to diet-induced hyperhomocysteinemia and hyperhomocysteinemia alters tissue methylation capacity and impairs endothelial function in cerebral microvessels. GeneRIF 17769
Multiple single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase and its truncated pseudogene of 23 inbred strains of mice. Takeya C., Esumi M., Shiroishi T., Hishida R., Yamamoto T. Biochem. Biophys. Res. Commun. 312:480-486(2003) GeneRIF 17769 · Mapped (13) These results suggest a possibility that the truncated pseudogene may buffer variations of the mouse Mthfr functional gene and the mouse has evolved fewer variations of the gene than human GeneRIF 17769
Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice. Li D., Pickell L., Liu Y., Rozen R. Birth Defects Res. Part A Clin. Mol. Teratol. 76:55-59(2006) GeneRIF 17769 MGI 106639 · Mapped (18) No interaction between Sp and Mthfr mutations or between the Sp mutation and low dietary folate in neural tube development were observed. GeneRIF 17769
Molecular genetics of MTHFR: polymorphisms are not all benign. Leclerc D., Rozen R. Med Sci (Paris) 23:297-302(2007) GeneRIF 17769 · Mapped (22) Review. A knockout mouse model for MTHFR deficiency displays hyperhomocysteinemia homocystinuria birth defects and lipid metabolism alterations. GeneRIF 17769
Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia. Schwahn B.C., Wang X.L., Mikael L.G., Wu Q., Cohn J., Jiang H., Maclean K.N., Rozen R. Atherosclerosis 195:e100-7(2007) GeneRIF 17769 · Mapped (13) Mild (methylenetetrahydrofolate reductase) MTHFR deficiency (heterozygotes) in mice is associated with increased risk for atherosclerotic disease GeneRIF 17769
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer. Leclerc D., Rozen R. J. Biol. Chem. 283:3151-3160(2008) GeneRIF 17769 · Mapped (35) ER stress increases MTHFR expression and IRE1 and c-Jun mediate this activation GeneRIF 17769
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice. Celtikci B., Leclerc D., Lawrance A.K., Deng L., Friedman H.C., Krupenko N.I., Krupenko S.A., Melnyk S., James S.J., Peterson A.C. et al. Pharmacogenet. Genomics 18:577-589(2008) GeneRIF 17769 · Mapped (13) Underexpression and overexpression of Mthfr/MTHFR increase MTX-induced myelosuppression but have distinct effects on plasma homocysteine and nephrotoxicity. GeneRIF 17769
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. Roy M., Leclerc D., Wu Q., Gupta S., Kruger W.D., Rozen R. J. Cell. Biochem. 105:467-476(2008) GeneRIF 17769 · Mapped (22) VPA increases MTHFR expression and has lower teratogenic potential in MTHFR deficiency GeneRIF 17769
Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice. Pickell L., Li D., Brown K., Mikael L.G., Wang X.L., Wu Q., Luo L., Jerome-Majewska L., Rozen R. Birth Defects Res. Part A Clin. Mol. Teratol. 85:531-541(2009) GeneRIF 17769 · Mapped (13) Maternal MTHFR and folate deficiencies resulted in increased developmental delays and smaller embryos. GeneRIF 17769
Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency. Mikael L.G., Wang X.L., Wu Q., Jiang H., Maclean K.N., Rozen R. Mol. Genet. Metab. 98:187-194(2009) GeneRIF 17769 MGI 106639 · Mapped (20) Hyperhomocysteinemia is associated with hypertriglyceridemia and that MTHFR deficiency may exacerbate lipid accumulation in ApoE deficiency. GeneRIF 17769
The human and mouse methylenetetrahydrofolate reductase (MTHFR) genes: genomic organization, mRNA structure and linkage to the CLCN6 gene. Gaughan D.J., Barbaux S., Kluijtmans L.A., Whitehead A.S. Gene 257:279-289(2000) MGI 106639 · Mapped (9)
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Chen Z., Karaplis A.C., Ackerman S.L., Pogribny I.P., Melnyk S., Lussier-Cacan S., Chen M.F., Pai A., John S.W., Smith R.S. et al. Hum. Mol. Genet. 10:433-443(2001) MGI 106639 · Mapped (9)
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D., Kawamoto M., Huang C.C., Johns S.J., King L.A., Harper C.A., Meng E.C., Lee R.E., Yee A., L'Italien L. et al. Nucleic Acids Res. 31:278-281(2003) MGI 106639 · Mapped (8,067)
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. Schwahn B.C., Chen Z., Laryea M.D., Wendel U., Lussier-Cacan S., Genest J. Jr., Mar M.H., Zeisel S.H., Castro C., Garrow T. et al. FASEB J. 17:512-514(2003) MGI 106639 · Mapped (9)
Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Virdis A., Iglarz M., Neves M.F., Amiri F., Touyz R.M., Rozen R., Schiffrin E.L. Arterioscler. Thromb. Vasc. Biol. 23:1352-1357(2003) MGI 106639 · Mapped (9)
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz B.P., Abuin A., Ramirez-Solis R., Richter L.J., Piggott J., BeltrandelRio H., Buxton E.C., Edwards J., Finch R.A., Friddle C.J. et al. Proc. Natl. Acad. Sci. U.S.A. 100:14109-14114(2003) MGI 106639 · Mapped (17,104)
Small artery mechanics in hyperhomocysteinemic mice: effects of angiotensin II. Neves M.F., Endemann D., Amiri F., Virdis A., Pu Q., Rozen R., Schiffrin E.L. J. Hypertens. 22:959-966(2004) MGI 106639 · Mapped (9)
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency. Schwahn B.C., Laryea M.D., Chen Z., Melnyk S., Pogribny I., Garrow T., James S.J., Rozen R. Biochem. J. 382:831-840(2004) MGI 106639 GeneRIF 17769 · Mapped (14) important role for choline and betaine depletion in the pathogenesis of homocystinuria due to MTHFR deficiency GeneRIF 17769
Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates. Ghandour H., Chen Z., Selhub J., Rozen R. J. Nutr. 134:2975-2978(2004) MGI 106639 · Mapped (9)
Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation. Kelly T.L., Neaga O.R., Schwahn B.C., Rozen R., Trasler J.M. Biol. Reprod. 72:667-677(2005) MGI 106639 · Mapped (9)
Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase. Chen Z., Schwahn B.C., Wu Q., He X., Rozen R. Int. J. Dev. Neurosci. 23:465-474(2005) MGI 106639 GeneRIF 17769 · Mapped (13) MTHFR plays a role in cerebellar patterning possibly through effects on proliferation or apoptosis. GeneRIF 17769
The transcriptional landscape of the mammalian genome. Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C. et al. Science 309:1559-1563(2005) MGI 106639 · UniProtKB (27,417) · Mapped (5,721)
Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity. Pickell L., Tran P., Leclerc D., Hiscott J., Rozen R. Biochim. Biophys. Acta 1731:104-114(2005) MGI 106639 GeneRIF 17769 · Mapped (18) the elucidation of Mthfr regulation demonstrates that two TATA-less GC-rich promoters differentially drive transcription of Mthfr in a cell-specific manner and provides a novel link of Mthfr to possible roles in the immune response and cell survival GeneRIF 17769