Patterson C.

Sci. STKE 2002:pe4-pe4(2002) GeneRIF 10273 · Mapped (2)
Ubiquitin ligases (u box) determine protein stability in a highly regulated manner by coordinating the addition of polyubiquitin chains to proteins that are then targeted to the proteasome for degradation. GeneRIF 10273

Cardozo C.P., Michaud C., Ost M.C., Fliss A.E., Yang E., Patterson C., Hall S.J., Caplan A.J.

Arch. Biochem. Biophys. 410:134-140(2003) GeneRIF 10273 · Mapped (12)
Chip overexpression reduced the rate of AR degradation consistent with an effect on AR folding Chip affected AR folding was further supported by the finding that the effects of exogenous Chip were reproduced by a mutant lacking the U box GeneRIF 10273

Zhou P., Fernandes N., Dodge I.L., Reddi A.L., Rao N., Safran H., DiPetrillo T.A., Wazer D.E., Band V., Band H.

J. Biol. Chem. 278:13829-13837(2003) GeneRIF 10273 · Mapped (9)
CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90 GeneRIF 10273

Shimura H., Schwartz D., Gygi S.P., Kosik K.S.

J. Biol. Chem. 279:4869-4876(2004) GeneRIF 10273 · Mapped (19)
tau binds to Hsc70 and its phosphorylation is a recognition requirement for the addition of ubiquitin by the E3 Ub ligase CHIP GeneRIF 10273

Li L., Xin H., Xu X., Huang M., Zhang X., Chen Y., Zhang S., Fu X.Y., Chang Z.

Mol. Cell. Biol. 24:856-864(2004) GeneRIF 10273 · Mapped (5)
CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. GeneRIF 10273

Petrucelli L., Dickson D., Kehoe K., Taylor J., Snyder H., Grover A., De Lucia M., McGowan E., Lewis J., Prihar G. et al.

Hum. Mol. Genet. 13:703-714(2004) GeneRIF 10273 · Mapped (12)
Hsp70/CHIP may play an important role in the pathogenesis of tauopathies GeneRIF 10273

Galigniana M.D., Harrell J.M., Housley P.R., Patterson C., Fisher S.K., Pratt W.B.

Brain Res. Mol. Brain Res. 123:27-36(2004) GeneRIF 10273 · Mapped (9)
In cells treated with dexamethasone and geldanamycin the GFP-GR becomes concentrated in fluorescent globules located periodically along the neurites. CHIP protein concentrates in the same loci in a steroid-dependent and geldanamycin-dependent manner. GeneRIF 10273

He B., Bai S., Hnat A.T., Kalman R.I., Minges J.T., Patterson C., Wilson E.M.

J. Biol. Chem. 279:30643-30653(2004) GeneRIF 10273 · Mapped (12)
CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation GeneRIF 10273

Choi J.S., Cho S., Park S.G., Park B.C., Lee D.H.

Biochem. Biophys. Res. Commun. 321:574-583(2004) GeneRIF 10273 · Mapped (3)
Results suggest that co-chaperone CHIP possibly with another E3 ligase(s) modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. GeneRIF 10273

Wang X., DeFranco D.B.

Mol. Endocrinol. 19:1474-1482(2005) GeneRIF 10273 · Mapped (21)
CHIP is an E3 ligase that mediates alternative effects of the ubiquitin-proteasome pathway on glucocorticoid receptor down-regulation and transactivation GeneRIF 10273

Xin H., Xu X., Li L., Ning H., Rong Y., Shang Y., Wang Y., Fu X.Y., Chang Z.

J. Biol. Chem. 280:20842-20850(2005) GeneRIF 10273 · Mapped (1)
findings suggest that CHIP can modulate the sensitivity of the TGF-beta signaling by controlling the basal level of Smad3 through ubiquitin-mediated degradation GeneRIF 10273

Esser C., Scheffner M., Hohfeld J.

J. Biol. Chem. 280:27443-27448(2005) GeneRIF 10273 · Mapped (33)
CHIP-induced degradation was observed for mutant and wild-type p53 which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association GeneRIF 10273

Fan M., Park A., Nephew K.P.

Mol. Endocrinol. 19:2901-2914(2005) GeneRIF 10273 · Mapped (59)
CHIP promotes ERalpha degradation and attenuates receptor-mediated gene transcription. GeneRIF 10273

Sahara N., Murayama M., Mizoroki T., Urushitani M., Imai Y., Takahashi R., Murata S., Tanaka K., Takashima A.

J. Neurochem. 94:1254-1263(2005) GeneRIF 10273 · Mapped (3)
Increases in CHIP may protect against neurofibrillary tangles formation in the early stages of Alzheimer's disease. GeneRIF 10273

Arndt V., Daniel C., Nastainczyk W., Alberti S., Hohfeld J.

Mol. Biol. Cell 16:5891-5900(2005) GeneRIF 10273 · Mapped (6)
Hsc70 cochaperone BAG-2 as a main component of CHIP complexes. BAG-2 inhibits the ubiquitin ligase activity of CHIP. GeneRIF 10273

Kim S.A., Yoon J.H., Kim D.K., Kim S.G., Ahn S.G.

FEBS Lett. 579:6559-6563(2005) GeneRIF 10273 · Mapped (7)
CHIP directly interacts with C-terminal deleted HSF1 but not with full-length HSF1 under non-stressed conditions and with full-length HSF1 under heat shock treatment; interaction requires conformational change of HSF1 by heat stress. GeneRIF 10273

Murata T., Shimotohno K.

J. Biol. Chem. 281:20788-20800(2006) GeneRIF 10273 · Mapped (3)
Chip may be at least one ubiquitin E3 ligase responsible for eIF4E ubiquitination GeneRIF 10273

Rees I., Lee S., Kim H., Tsai F.T.

Biochim. Biophys. Acta 1764:1073-1079(2006) GeneRIF 10273 · Mapped (12)
CHIP recognizes AR in a highly specific phosphorylation- and sequence-dependent manner GeneRIF 10273

Al-Ramahi I., Lam Y.C., Chen H.K., de Gouyon B., Zhang M., Perez A.M., Branco J., de Haro M., Patterson C., Zoghbi H.Y. et al.

J. Biol. Chem. 281:26714-26724(2006) GeneRIF 10273 · Mapped (7)
Results show that CHIP and ataxin-1 proteins directly interact and co-localize in nuclear inclusions both in cell culture and spinocerebellar ataxia type-1 postmortem neurons. GeneRIF 10273

Choi J.Y., Ryu J.H., Kim H.S., Park S.G., Bae K.H., Kang S., Myung P.K., Cho S., Park B.C., Lee d.o. H.

Mol. Cell. Neurosci. 34:69-79(2007) GeneRIF 10273 · Mapped (1)
Our findings suggest that the role of CHIP in aggregation of polyQ proteins greatly varies depending on the context of full-length polyQ proteins. GeneRIF 10273

Dickey C.A., Kamal A., Lundgren K., Klosak N., Bailey R.M., Dunmore J., Ash P., Shoraka S., Zlatkovic J., Eckman C.B. et al.

J. Clin. Invest. 117:648-658(2007) GeneRIF 10273 · Mapped (26)
A critical mediator of Hsp90 inhibition leading to p-tau degradation is CHIP. GeneRIF 10273

Zhang L., Nephew K.P., Gallagher P.J.

J. Biol. Chem. 282:11795-11804(2007) GeneRIF 10273 · Mapped (17)
DAPK is found in two distinct immune complexes one containing HSP90 and CHIP and a second complex containing only DIP1/Mib; strict modulation of DAPK activities by HSP90 heterocomplexes is critical for regulation of apoptosis and cellular homeostasis GeneRIF 10273

Rosser M.F., Washburn E., Muchowski P.J., Patterson C., Cyr D.M.

J. Biol. Chem. 282:22267-22277(2007) GeneRIF 10273 · Mapped (1)
CHIP possesses an intrinsic chaperone activity that enables it to selectively recognize and bind nonnative proteins GeneRIF 10273

Tripathi V., Ali A., Bhat R., Pati U.

J. Biol. Chem. 282:28441-28454(2007) GeneRIF 10273 · Mapped (33)
CHIP might be a direct chaperone of wild type p53 that helps p53 in maintaining wild type conformation under physiological condition as well as help resurrect p53 mutant phenotype into a folded native state under stress condition. GeneRIF 10273

Nie L., Wu H., Sun X.H.

J. Biol. Chem. 283:684-692(2008) GeneRIF 10273 · UniProtKB (1) · Mapped (6)
Ubiquitin ligase activity of CHIP is dispensable for Tal1/SCL binding but essential for degradation. GeneRIF 10273