Edinger A.L., Thompson C.B.

Mol. Biol. Cell 13:2276-2288(2002) GeneRIF 56717 · Mapped (6)
These results suggest that growth factors control cellular growth and survival by regulating cellular access to extracellular nutrients in part by modulating the activity of Akt and mTOR GeneRIF 56717

Mayerhofer M., Valent P., Sperr W.R., Griffin J.D., Sillaber C.

Blood 100:3767-3775(2002) GeneRIF 56717 · Mapped (11)
BCR/ABL induces expression of VEGF and its transcriptional activator HIF1A through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin (FRAP) in BaF3 cells. GeneRIF 56717

Brugarolas J.B., Vazquez F., Reddy A., Sellers W.R., Kaelin W.G. Jr.

Cancer Cell 4:147-158(2003) GeneRIF 56717 · Mapped (15)
mTOR-independent link between TSC2 loss and VEGF GeneRIF 56717

Kwon C.H., Zhu X., Zhang J., Baker S.J.

Proc. Natl. Acad. Sci. U.S.A. 100:12923-12928(2003) GeneRIF 56717 · Mapped (7)
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. GeneRIF 56717

Zhang H., Cicchetti G., Onda H., Koon H.B., Asrican K., Bajraszewski N., Vazquez F., Carpenter C.L., Kwiatkowski D.J.

J. Clin. Invest. 112:1223-1233(2003) GeneRIF 56717 · Mapped (29)
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. GeneRIF 56717

Gual P., Gremeaux T., Gonzalez T., Le Marchand-Brustel Y., Tanti J.F.

Diabetologia 46:1532-1542(2003) GeneRIF 56717 MGI 1928394 · Mapped (11)
Insulin-induced phosphorylation of Serine(307) was dependent on the activation of a PI 3-kinase/mTOR pathway GeneRIF 56717

Hannan K.M., Brandenburger Y., Jenkins A., Sharkey K., Cavanaugh A., Rothblum L., Moss T., Poortinga G., McArthur G.A., Pearson R.B. et al.

Mol. Cell. Biol. 23:8862-8877(2003) GeneRIF 56717 · Mapped (10)
mTOR plays a critical role in the regulation of ribosome biogenesis via a mechanism that requires S6K1 activation and phosphorylation of UBF. GeneRIF 56717

Bliskovsky V., Ramsay E.S., Scott J., DuBois W., Shi W., Zhang S., Qian X., Lowy D.R., Mock B.A.

Proc. Natl. Acad. Sci. U.S.A. 100:14982-14987(2003) GeneRIF 56717 MGI 1928394 · Mapped (7)
Frap is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene GeneRIF 56717

Majumder P.K., Febbo P.G., Bikoff R., Berger R., Xue Q., McMahon L.M., Manola J., Brugarolas J., McDonnell T.J., Golub T.R. et al.

Nat. Med. 10:594-601(2004) GeneRIF 56717 · Mapped (11)
Data suggest that the expansion of AKT-driven prostate epithelial cells requires mTOR-dependent survival signaling and activation of hypoxia inducible factor (HIF)-1 alpha. GeneRIF 56717

Hou L., Klann E.

J. Neurosci. 24:6352-6361(2004) GeneRIF 56717 · Mapped (17)
Activation of the PI3K-Akt-mTOR signaling cascade is required for mGluR-mediated long-term depression in the hippocampus. GeneRIF 56717

Murakami M., Ichisaka T., Maeda M., Oshiro N., Hara K., Edenhofer F., Kiyama H., Yonezawa K., Yamanaka S.

Mol. Cell. Biol. 24:6710-6718(2004) GeneRIF 56717 MGI 1928394 · Mapped (3)
mTOR controls both cell size and proliferation in early mouse embryos and embryonic stem cells GeneRIF 56717

Latres E., Amini A.R., Amini A.A., Griffiths J., Martin F.J., Wei Y., Lin H.C., Yancopoulos G.D., Glass D.J.

J. Biol. Chem. 280:2737-2744(2005) GeneRIF 56717 · Mapped (8)
both the Akt/FOXO and the Akt/mTOR pathways are required for the transcriptional changes induced by IGF-1 GeneRIF 56717

Tremblay F., Gagnon A., Veilleux A., Sorisky A., Marette A.

Endocrinology 146:1328-1337(2005) GeneRIF 56717 · Mapped (8)
the mTOR pathway is an important modulator of the signals involved in the acute regulation of insulin-stimulated glucose transport in 3T3-L1 and human adipocytes GeneRIF 56717

Corradetti M.N., Inoki K., Guan K.-L.

J. Biol. Chem. 280:9769-9772(2005) GeneRIF 56717 · UniProtKB (4) · Mapped (15)
RTP801 and RTP801L work downstream of AKT and upstream of TSC2 to inhibit mTOR functions GeneRIF 56717

Ohanna M., Sobering A.K., Lapointe T., Lorenzo L., Praud C., Petroulakis E., Sonenberg N., Kelly P.A., Sotiropoulos A., Pende M.

Nat. Cell Biol. 7:286-294(2005) GeneRIF 56717 · Mapped (25)
S6 kinase 1 is essential for the control of muscle cytoplasmic volume by Akt and mTOR GeneRIF 56717

Smith E.M., Finn S.G., Tee A.R., Browne G.J., Proud C.G.

J. Biol. Chem. 280:18717-18727(2005) GeneRIF 56717 · Mapped (15)
TSC2 is not required for the regulation of mTOR by amino acids and certain cellular stresses GeneRIF 56717

Chen J.K., Chen J., Neilson E.G., Harris R.C.

J. Am. Soc. Nephrol. 16:1384-1391(2005) GeneRIF 56717 · Mapped (3)
activation of the mTOR signaling pathway in the remaining kidney after unilateral nephrectomy plays an essential role in modulating RNA and protein synthesis during development of compensatory renal hypertrophy GeneRIF 56717

Ohguchi K., Banno Y., Nakagawa Y., Akao Y., Nozawa Y.

J. Cell. Physiol. 205:444-451(2005) GeneRIF 56717 · Mapped (12)
Phospholipase D1 exerts a negative regulatory role in the melanogenic process through mTOR/S6K1 signaling. GeneRIF 56717

Park I.H., Erbay E., Nuzzi P., Chen J.

Exp. Cell Res. 309:211-219(2005) GeneRIF 56717 MGI 1928394 · Mapped (9)
the requirement of mTOR and its downstream effector S6K1 in the regulation of myotube hypertrophy GeneRIF 56717

Hu X., Pandolfi P.P., Li Y., Koutcher J.A., Rosenblum M., Holland E.C.

Neoplasia 7:356-368(2005) GeneRIF 56717 · Mapped (14)
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma GeneRIF 56717

Hahn-Windgassen A., Nogueira V., Chen C.C., Skeen J.E., Sonenberg N., Hay N.

J. Biol. Chem. 280:32081-32089(2005) GeneRIF 56717 · Mapped (16)
activation of mTOR by Akt-mediated cellular energy and inhibition of AMPK is the predominant pathway by which Akt activates mTOR in vivo GeneRIF 56717

Hiratani K., Haruta T., Tani A., Kawahara J., Usui I., Kobayashi M.

Biochem. Biophys. Res. Commun. 335:836-842(2005) GeneRIF 56717 · Mapped (12)
mTOR and JNK play roles in phosphorylating IRS-1 serine residues and that insulin and anisomycin are different in terms of the relationship of activation between mTOR and JNK and the effects on IRS-1 localization and stability GeneRIF 56717

Lenz G., Avruch J.

J. Biol. Chem. 280:38121-38124(2005) GeneRIF 56717 · Mapped (9)
the mTOR-S6K pathway in neurons is activated by glutamatergic stimulation in a calcium/calmodulin-dependent fashion through a calcium pool controlled by postsynaptic voltage-dependent calcium channels GeneRIF 56717

Thomas G.V., Tran C., Mellinghoff I.K., Welsbie D.S., Chan E., Fueger B., Czernin J., Sawyers C.L.

Nat. Med. 12:122-127(2006) GeneRIF 56717 · Mapped (20)
HIF1a has a role in determining sensitivity to inhibitors of mTOR in kidney cancer GeneRIF 56717

Sakaguchi M., Isono M., Isshiki K., Sugimoto T., Koya D., Kashiwagi A.

Biochem. Biophys. Res. Commun. 340:296-301(2006) GeneRIF 56717 · Mapped (3)
Our findings suggest that activation of mTOR signaling causes renal hypertrophy at the early stage of diabetes. GeneRIF 56717