Bonuccelli G., Sotgia F., Frank P.G., Williams T.M., de Almeida C.J., Tanowitz H.B., Scherer P.E., Hotchkiss K.A., Terman B.I., Rollman B. et al.

Am. J. Physiol., Cell Physiol. 288:C1402-10(2005) GeneRIF 84168 · Mapped (7)
ATR/TEM8 protein is highly expressed in epithelial cells which represent the primary location for bacterial invasion; This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection. GeneRIF 84168

Rmali K.A., Puntis M.C., Jiang W.G.

Biochem. Biophys. Res. Commun. 334:231-238(2005) GeneRIF 84168 · Mapped (6)
These results suggest that the TEM-8 vW and transmembrane domains may play an important biological role in TEM-8 related tubule formation. GeneRIF 84168

Rainey G.J., Wigelsworth D.J., Ryan P.L., Scobie H.M., Collier R.J., Young J.A.

Proc. Natl. Acad. Sci. U.S.A. 102:13278-13283(2005) GeneRIF 84168 · Mapped (6)
because protective antigen binds to CMG2 with much higher affinity than it does to TEM8 a lower pH is needed to attenuate CMG2 binding to allow pore formation; toxin can form pores at different points in the endocytic pathway GeneRIF 84168

Abrami L., Leppla S.H., van der Goot F.G.

J. Cell Biol. 172:309-320(2006) GeneRIF 84168 · Mapped (9)
Data show that cells expressing palmitoylation-defective mutant receptors are less sensitive to anthrax toxin due to a lower number of surface receptors as well as premature internalization of protective antigen without a requirement for heptamerization. GeneRIF 84168

Venanzi F.M., Petrini M., Fiammenghi L., Bolli E., Granato A.M., Ridolfi L., Gabrielli F., Barucca A., Concetti A., Ridolfi R. et al.

Cancer Immunol. Immunother. 59:27-34(2010) GeneRIF 84168 · Mapped (6)
TEM8 expression levels in DC-based therapeutic vaccines would allow the selection of a subgroup of patients who are most likely to benefit from therapeutic vaccination. GeneRIF 84168

Garlick K.M., Mogridge J.

Biochemistry 48:10577-10581(2009) GeneRIF 84168 · Mapped (6)
ANTXR1 does not use an adaptor to bind the cytoskeleton. This peptide orders actin filaments into arrays demonstrating an actin bundling activity that is novel for a membrane protein GeneRIF 84168

Wheeler H.E., Metter E.J., Tanaka T., Absher D., Higgins J., Zahn J.M., Wilhelmy J., Davis R.W., Singleton A., Myers R.M. et al.

PLoS Genet. 5:e1000685-e1000685(2009) GeneRIF 84168 · Mapped (336)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 84168

Abrami L., Bischofberger M., Kunz B., Groux R., van der Goot F.G.

PLoS Pathog. 6:e1000792-e1000792(2010) GeneRIF 84168 · Mapped (6)
actin was also found to be essential for efficient heptamerization of anthrax toxin PA but only when bound to one of its 2 receptors TEM8 GeneRIF 84168

Kintzer A.F., Sterling H.J., Tang I.I., Williams E.R., Krantz B.A.

PLoS ONE 5:e13888-e13888(2010) GeneRIF 84168 · Mapped (6)
Data show that the two different PA oligomers are equally stabilized by ANTXR interactions. GeneRIF 84168

Yang M.Y., Chaudhary A., Seaman S., Dunty J., Stevens J., Elzarrad M.K., Frankel A.E., St Croix B.

Biochim. Biophys. Acta 1813:39-49(2011) GeneRIF 84168 · Mapped (7)
studies reveal that TEM8 exists in different forms at the cell surface a structure dependent on interactions with components of the actin cytoskeleton GeneRIF 84168

Cai C., Zhao Y., Tong X., Fu S., Li Y., Wu Y., Li X., Lou Z.

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67:64-67(2011) GeneRIF 84168 · Mapped (6)
Results describe the expression purification and crystallization of human anthrax toxin receptor 1 vWA domain to 1.8 A resolution from a single crystal. GeneRIF 84168

Raeisossadati R., Farshchian M., Ganji A., Tavassoli A., Velayati A., Dadkhah E., Chavoshi S., Mehrabi Bahar M., Memar B., Rajabi Mashhadi M.T. et al.

Int J Colorectal Dis 26:1265-1270(2011) GeneRIF 84168 · Mapped (13)
The copy number of CEA and TEM-8 mRNA as detected by a real-time quantitative PCR appears to be a promising marker for evaluating the risk of tumor spread. GeneRIF 84168

Verma K., Gu J., Werner E.

PLoS ONE 6:e22334-e22334(2011) GeneRIF 84168 · Mapped (6)
postulate that the developmentally controlled expression of TEM8 modulates endothelial cell response to canonical Wnt signaling to regulate vessel patterning and density GeneRIF 84168

Gutwein L.G., Al-Quran S.Z., Fernando S., Fletcher B.S., Copeland E.M., Grobmyer S.R.

Anticancer Res. 31:3417-3422(2011) GeneRIF 84168 · Mapped (6)
TEM8 was expressed at a higher level in the stroma adjacent to the triple-negative breast cancer in all cases with focal immunoreactive areas within the tumor. GeneRIF 84168

Opoku-Darko M., Yuen C., Gratton K., Sampson E., Bathe O.F.

Cancer Invest. 29:676-682(2011) GeneRIF 84168 · Mapped (6)
TEM8.1 expression in breast cancer cells confers a more aggressive proangiogenic phenotype. GeneRIF 84168

Garlick K.M., Batty S., Mogridge J.

Biochemistry 51:1249-1256(2012) GeneRIF 84168 · Mapped (6)
An acidic region in the cytosolic tail of ANTXR1 decreases actin association sending a signal that prevents binding of ANTXR1 to the protective antigen and providing evidence that cytoskeletal dynamics regulate ANTXR1 function. GeneRIF 84168

Chaudhary A., Hilton M.B., Seaman S., Haines D.C., Stevenson S., Lemotte P.K., Tschantz W.R., Zhang X.M., Saha S., Fleming T. et al.

Cancer Cell 21:212-226(2012) GeneRIF 84168 · Mapped (7)
Disruption of Tem8 results in impaired growth of human tumor xenografts of diverse origin including melanoma breast colon and lung cancer. GeneRIF 84168

Vargas M., Karamsetty R., Leppla S.H., Chaudry G.J.

PLoS ONE 7:e43174-e43174(2012) GeneRIF 84168 · UniProtKB (2) · Mapped (4)
Two new splice variants one encoding a membrane-bound form of the receptor and the other secreted which we have designated V4 and V5 (the latter being the only variant expressed in the prostate). GeneRIF 84168