Kimura H., Morii E., Ikeda J.I., Ezoe S., Xu J.X., Nakamichi N., Tomita Y., Shibayama H., Kanakura Y., Aozasa K.

Leukemia 20:1551-1556(2006) GeneRIF 64866 · Mapped (1)
When CDCP1 promoter was transfected exogenously Jurkat showed comparable promoter activity with K562 suggesting that the factor to enhance transcription was present but interfered to function in Jurkat GeneRIF 64866

Uekita T., Jia L., Narisawa-Saito M., Yokota J., Kiyono T., Sakai R.

Mol. Cell. Biol. 27:7649-7660(2007) GeneRIF 64866 · Mapped (1)
CUB-domain-containing protein 1 (CDCP1) is identified as an Src family kinases-binding phosphoprotein associated with the anchorage independence of human lung adenocarcinoma. GeneRIF 64866

Alvares S.M., Dunn C.A., Brown T.A., Wayner E.E., Carter W.G.

Biochim. Biophys. Acta 1780:486-496(2008) GeneRIF 64866 · Mapped (1)
The clustering of Gp140 and signaling components in membrane microdomains in cell-cell contacts contributes to changes in cell behavior. GeneRIF 64866

Uekita T., Tanaka M., Takigahira M., Miyazawa Y., Nakanishi Y., Kanai Y., Yanagihara K., Sakai R.

Am. J. Pathol. 172:1729-1739(2008) GeneRIF 64866 · Mapped (1)
CDCP1 promotes invasion and peritoneal dissemination of cancer cells through the regulation of cell migration and anchorage independence. GeneRIF 64866

Siva A.C., Wild M.A., Kirkland R.E., Nolan M.J., Lin B., Maruyama T., Yantiri-Wernimont F., Frederickson S., Bowdish K.S., Xin H.

Cancer Res. 68:3759-3766(2008) GeneRIF 64866 · Mapped (1)
CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model GeneRIF 64866

Awakura Y., Nakamura E., Takahashi T., Kotani H., Mikami Y., Kadowaki T., Myoumoto A., Akiyama H., Ito N., Kamoto T. et al.

J. Cancer Res. Clin. Oncol. 134:1363-1369(2008) GeneRIF 64866 · Mapped (1)
Overexpression of CUB-domain containing protein 1 is associated with metastasis and recurrence in renal cell carcinoma. GeneRIF 64866

Ikeda J., Oda T., Inoue M., Uekita T., Sakai R., Okumura M., Aozasa K., Morii E.

Cancer Sci. 100:429-433(2009) GeneRIF 64866 · Mapped (1)
CDCP1 expression level is a useful marker for prediction of patients with lung adenocarcinoma GeneRIF 64866

Wong C.H., Baehner F.L., Spassov D.S., Ahuja D., Wang D., Hann B., Blair J., Shokat K., Welm A.L., Moasser M.M.

Clin. Cancer Res. 15:2311-2322(2009) GeneRIF 64866 · Mapped (1)
abberant Trask phosphorylation is seen in many epithelial tumors from all stages including preinvasive invasive and metastatic tumors. GeneRIF 64866

Deryugina E.I., Conn E.M., Wortmann A., Partridge J.J., Kupriyanova T.A., Ardi V.C., Hooper J.D., Quigley J.P.

Mol. Cancer Res. 7:1197-1211(2009) GeneRIF 64866 · Mapped (1)
These findings confirm that CDCP1 functions as an antiapoptotic molecule and indicate that during metastasis CDCP1 facilitates tumor cell survival likely during or soon after extravasation. GeneRIF 64866

Fukuchi K., Steiniger S.C., Deryugina E., Liu Y., Lowery C.A., Gloeckner C., Zhou B., Kaufmann G.F., Quigley J.P., Janda K.D.

Mol. Pharm. 7:245-253(2010) GeneRIF 64866 · Mapped (1)
findings indicate a functional role for CDCP1 in cancer and underscore the therapeutic potential of function-blocking anti-CDCP1 antibodies targeting both primary and metastatic carcinoma cells GeneRIF 64866

Mamat S., Ikeda J., Enomoto T., Ueda Y., Rahadiani N., Tian T., Wang Y., Qiu Y., Kimura T., Aozasa K. et al.

Oncol. Rep. 23:1221-1227(2010) GeneRIF 64866 · Mapped (1)
In endometrioid adenocarcinoma low CDCP1 and advanced stage were independent poor prognostic factors for both overall and disease-free survival. GeneRIF 64866

Miyazawa Y., Uekita T., Hiraoka N., Fujii S., Kosuge T., Kanai Y., Nojima Y., Sakai R.

Cancer Res. 70:5136-5146(2010) GeneRIF 64866 · Mapped (1)
Overexpression of CDCP1 is associated with pancreatic cancers. GeneRIF 64866

He Y., Wortmann A., Burke L.J., Reid J.C., Adams M.N., Abdul-Jabbar I., Quigley J.P., Leduc R., Kirchhofer D., Hooper J.D.

J. Biol. Chem. 285:26162-26173(2010) GeneRIF 64866 · Mapped (1)
biological role of this protein and potentially its function in cancer may be mediated by both 70-kDa cell retained and 65-kDa shed fragments as well as the full-length 135-kDa protein. GeneRIF 64866

Spassov D.S., Wong C.H., Sergina N., Ahuja D., Fried M., Sheppard D., Moasser M.M.

Mol. Cell. Biol. 31:766-782(2011) GeneRIF 64866 · Mapped (1)
Trask signaling and focal adhesion signaling inactivate each other and signal in exclusion with each other constituting a switch that underlies cell anchorage state. GeneRIF 64866

Liu H., Ong S.E., Badu-Nkansah K., Schindler J., White F.M., Hynes R.O.

Proc. Natl. Acad. Sci. U.S.A. 108:1379-1384(2011) GeneRIF 64866 · Mapped (1)
Data provide molecular mechanisms for the metastasis-enhancing functions of CDCP1. GeneRIF 64866

Razorenova O.V., Finger E.C., Colavitti R., Chernikova S.B., Boiko A.D., Chan C.K., Krieg A., Bedogni B., LaGory E., Weissman I.L. et al.

Proc. Natl. Acad. Sci. U.S.A. 108:1931-1936(2011) GeneRIF 64866 · Mapped (6)
Signal transduction from CDCP1 to PKCdelta leads to its activation increasing migration of CC-RCC. Furthermore patient survival can be stratified by CDCP1 expression at the cell surface of the tumor GeneRIF 64866

Spassov D.S., Wong C.H., Moasser M.M.

Cell Cycle 10:1225-1232(2011) GeneRIF 64866 · Mapped (4)
Src-Trask signaling and Src-focal adhesion signaling inactivate each other constituting two opposing modes of phosphotyrosine signaling that define a switch underlining cell anchorage state. GeneRIF 64866

Spassov D.S., Ahuja D., Wong C.H., Moasser M.M.

PLoS ONE 6:e19154-e19154(2011) GeneRIF 64866 · Mapped (1)
analysis of structural features of Trask that mediate its anti-adhesive functions GeneRIF 64866

Sasaroli D., Gimotty P.A., Pathak H.B., Hammond R., Kougioumtzidou E., Katsaros D., Buckanovich R., Devarajan K., Sandaltzopoulos R., Godwin A.K. et al.

Cancer Biol. Ther. 12:169-180(2011) GeneRIF 64866 · Mapped (3)
CDCP1 is selectively expressed in ovarian tumor vasculature GeneRIF 64866

Spassov D.S., Wong C.H., Harris G., McDonough S., Phojanakong P., Wang D., Hann B., Bazarov A.V., Yaswen P., Khanafshar E. et al.

Oncogene 31:419-431(2012) GeneRIF 64866 · Mapped (8)
Trask as one of several potential candidates for functionally relevant tumor suppressors on the 3p21.3 region of the genome frequently lost in human cancers. GeneRIF 64866

Uekita T., Sakai R.

Cancer Sci. 102:1943-1948(2011) GeneRIF 64866 · Mapped (1)
CUB domain-containing protein 1 (CDCP1) is a substrate of Src family kinases and has been shown to regulate anoikis resistance migration and matrix degradation during tumor invasion and metastasis in a tyrosine phosphorylation-dependent manner. Review. GeneRIF 64866

Wortmann A., He Y., Christensen M.E., Linn M., Lumley J.W., Pollock P.M., Waterhouse N.J., Hooper J.D.

J. Biol. Chem. 286:42303-42315(2011) GeneRIF 64866 · Mapped (10)
analysis of cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734 GeneRIF 64866

Dong Y., He Y., de Boer L., Stack M.S., Lumley J.W., Clements J.A., Hooper J.D.

J. Biol. Chem. 287:9792-9803(2012) GeneRIF 64866 · Mapped (20)
a novel role for CDCP1 in EGF/EGFR-induced cell migration and indicate that targeting of CDCP1 may be a rational approach to inhibit progression of cancers driven by EGFR signaling GeneRIF 64866

Sandvig K., Llorente A.

Mol. Cell Proteomics 11:M111.012914-M111.012914(2012) GeneRIF 64866 · Mapped (4)
Secreted CDCP1 can be a useful genetic marker for the diagnosis of metastatic prostate cancer. GeneRIF 64866