van Wering H.M., Huibregtse I.L., van der Zwan S.M., de Bie M.S., Dowling L.N., Boudreau F., Rings E.H., Grand R.J., Krasinski S.D.

J. Biol. Chem. 277:27659-27667(2002) GeneRIF 140628 · Mapped (21)
demonstrate that GATA-5 and HNF-1alpha physically associate both in vivo and in vitro and that this interaction is necessary for cooperative activation of the lactase-phlorizin hydrolase promoter GeneRIF 140628

Akiyama Y., Watkins N., Suzuki H., Jair K.W., van Engeland M., Esteller M., Sakai H., Ren C.Y., Yuasa Y., Herman J.G. et al.

Mol. Cell. Biol. 23:8429-8439(2003) GeneRIF 140628 · Mapped (9)
in colorectal cancer and gastric cancer promoter hypermethylation and transcriptional silencing are frequent for GATA-4 and -5 GeneRIF 140628

Guo M., Akiyama Y., House M.G., Hooker C.M., Heath E., Gabrielson E., Yang S.C., Han Y., Baylin S.B., Herman J.G. et al.

Clin. Cancer Res. 10:7917-7924(2004) GeneRIF 140628 · Mapped (9)
Hypermethylation of the GATA5 is associated with lung cancer GeneRIF 140628

Wakana K., Akiyama Y., Aso T., Yuasa Y.

Cancer Lett. 241:281-288(2006) GeneRIF 140628 · Mapped (9)
Methylation of GATA-5 was associated with ovarian carcinogenesis GeneRIF 140628

Guo M., House M.G., Akiyama Y., Qi Y., Capagna D., Harmon J., Baylin S.B., Brock M.V., Herman J.G.

Int. J. Cancer 119:2078-2083(2006) GeneRIF 140628 · Mapped (9)
Frequent silencing of GATA-4 and GATA-5 in human esophageal neoplasia is associated with gene promoter hypermethylation. GeneRIF 140628

Fu B., Guo M., Wang S., Campagna D., Luo M., Herman J.G., Iacobuzio-Donahue C.A.

Cancer Biol. Ther. 6:1546-1552(2007) GeneRIF 140628 · Mapped (9)
While hypermethylation of GATA-5 seems to be a universal feature among human tumors infrequent methylation of GATA-4 and its corresponding overexpression appears unique to pancreatic cancer from other tumor types reported thus far. GeneRIF 140628

Hellebrekers D.M., Lentjes M.H., van den Bosch S.M., Melotte V., Wouters K.A., Daenen K.L., Smits K.M., Akiyama Y., Yuasa Y., Sanduleanu S. et al.

Clin. Cancer Res. 15:3990-3997(2009) GeneRIF 140628 · Mapped (9)
Methylation of GATA4/5 is a common and specific event in colorectal carcinomas and GATA4/5 exhibit tumor suppressive effects in colorectal cancer cells in vitro. GATA4 methylation in fecal DNA may be of interest for colorectal cancer detection. GeneRIF 140628

Wen X.Z., Akiyama Y., Pan K.F., Liu Z.J., Lu Z.M., Zhou J., Gu L.K., Dong C.X., Zhu B.D., Ji J.F. et al.

World J. Gastroenterol. 16:1201-1208(2010) GeneRIF 140628 · Mapped (9)
Epigenetic inactivation of GATA-5 by methylation of CpG islands is an early frequent event during gastric carcinogenesis and is significantly correlated with H. pylori infection. GeneRIF 140628

Wang X., Kang G.H., Campan M., Weisenberger D.J., Long T.I., Cozen W., Bernstein L., Wu A.H., Siegmund K.D., Shibata D. et al.

PLoS ONE 6:e25985-e25985(2011) GeneRIF 140628 · Mapped (3)
Two new epigenetic subgroups of gastroesophageal adenocarcinomas were identified that differ to some extent in their survival rates risk factors of exposure and GATA5 DNA methylation. GeneRIF 140628

Chen B., Hsu R., Li Z., Kogut P.C., Du Q., Rouser K., Camoretti-Mercado B., Solway J.

Biochem. J. 446:89-98(2012) GeneRIF 140628 · Mapped (14)
USF1 transactivates GATA5 expression by binding to the E-box in its promoter GeneRIF 140628

Padang R., Bagnall R.D., Richmond D.R., Bannon P.G., Semsarian C.

J. Mol. Cell. Cardiol. 53:277-281(2012) GeneRIF 140628 · Mapped (3)
Rare non-synonymous variations in the functionally important GATA5 transcriptional activation domains may be important in the pathogenesis of BAV disease in humans. GeneRIF 140628

Wang X.H., Huang C.X., Wang Q., Li R.G., Xu Y.J., Liu X., Fang W.Y., Yang Y.Q.

Int. J. Mol. Med. 31:43-50(2013) GeneRIF 140628 · Mapped (3)
A novel heterozygous GATA5 loss-of-function mutation of p.W200G identified in a family with lone atrial fibrillation is reported. GeneRIF 140628