Saarikoski S.T., Rivera S.P., Hankinson O.

FEBS Lett. 530:186-190(2002) GeneRIF 123 · Mapped (9)
induction by hypoxia GeneRIF 123

Targett-Adams P., Chambers D., Gledhill S., Hope R.G., Coy J.F., Girod A., McLauchlan J.

J. Biol. Chem. 278:15998-16007(2003) GeneRIF 123 · Mapped (15)
targeting of the lipid droplet-binding adipocyte differentiation-related protein. GeneRIF 123

Bildirici I., Roh C.R., Schaiff W.T., Lewkowski B.M., Nelson D.M., Sadovsky Y.

J. Clin. Endocrinol. Metab. 88:6056-6062(2003) GeneRIF 123 · Mapped (24)
Expression of adipophilin is enhanced during trophoblast differentiation and is up-regulated by ligand-activated PPARgamma/retinoid X receptor. May contribute to fatty acid uptake by placenta. GeneRIF 123

Larigauderie G., Furman C., Jaye M., Lasselin C., Copin C., Fruchart J.C., Castro G., Rouis M.

Arterioscler. Thromb. Vasc. Biol. 24:504-510(2004) GeneRIF 123 · Mapped (7)
Stimulation of adipophilin expression in macrophages by modified LDL promotes triglyceride & cholesterol storage and reduces cholesterol efflux. Adipophilin might contribute in vivo to lipid accumulation in the intima of the arterial wall. GeneRIF 123

Nakamura N., Akashi T., Taneda T., Kogo H., Kikuchi A., Fujimoto T.

Biochem. Biophys. Res. Commun. 322:957-965(2004) GeneRIF 123 · Mapped (20)
GDP-bound ARF1 induces dissociation of ADRP from the Lipid droplet surface;. GeneRIF 123

Robenek H., Lorkowski S., Schnoor M., Troyer D.

J. Biol. Chem. 280:5789-5794(2005) GeneRIF 123 · UniProtKB (1) · Mapped (7)
TIP47 and adipophilin are components of many but not all the lipid droplets in THP-1 cells GeneRIF 123

Masuda Y., Itabe H., Odaki M., Hama K., Fujimoto Y., Mori M., Sasabe N., Aoki J., Arai H., Takano T.

J. Lipid Res. 47:87-98(2006) GeneRIF 123 · Mapped (15)
ADRP and TG regulate each other and the ubiquitin-proteasome system is involved in degradation of ADRP during regression of lipid-storing cells. GeneRIF 123

Tobin K.A., Harsem N.K., Dalen K.T., Staff A.C., Nebb H.I., Duttaroy A.K.

J. Lipid Res. 47:815-823(2006) GeneRIF 123 · Mapped (7)
Data demonstrate that adipose differentiation-related protein (ADRP) mRNA and protein are regulated by fatty acids in a human placental choriocarcinoma cell line (BeWo) and in primary human trophoblasts; ADFP mRNA and protein are increased by long-chain polyunsaturated fatty acids in a human placental choriocarcinoma cell line (BeWo) and in primary human trophoblasts. The ADFP protein might facilitate transplacental transfer of maternal fatty acids GeneRIF 123

Dalen K.T., Ulven S.M., Arntsen B.M., Solaas K., Nebb H.I.

J. Lipid Res. 47:931-943(2006) GeneRIF 123 · Mapped (17)
We demonstrate that ADFP is transcriptionally regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) in human hepatoma cells through a highly conserved direct repeat-1(DR-1) element. GeneRIF 123

Ohsaki Y., Maeda T., Maeda M., Tauchi-Sato K., Fujimoto T.

Biochem. Biophys. Res. Commun. 347:279-287(2006) GeneRIF 123 · Mapped (8)
The results suggested that the putative hydrophobic cleft is critical for the unique characteristics of TIP47. GeneRIF 123

Larigauderie G., Cuaz-Perolin C., Younes A.B., Furman C., Lasselin C., Copin C., Jaye M., Fruchart J.C., Rouis M.

FEBS J. 273:3498-3510(2006) GeneRIF 123 · Mapped (7)
Adipophilin expression in THP-1 macrophages altered the cellular content of different lipids and enhanced the size of lipid droplets GeneRIF 123

Magra A.L., Mertz P.S., Torday J.S., Londos C.

J. Lipid Res. 47:2367-2373(2006) GeneRIF 123 · Mapped (7)
adipose differentiation-related protein does not appear to have a role in lung surfactant production GeneRIF 123

Yao M., Huang Y., Shioi K., Hattori K., Murakami T., Nakaigawa N., Kishida T., Nagashima Y., Kubota Y.

Clin. Cancer Res. 13:152-160(2007) GeneRIF 123 · Mapped (7)
ADFP expression may have a role in clear cell renal carcinoma differentiation GeneRIF 123

Sarov-Blat L., Kiss R.S., Haidar B., Kavaslar N., Jaye M., Bertiaux M., Steplewski K., Hurle M.R., Sprecher D., McPherson R. et al.

Arterioscler. Thromb. Vasc. Biol. 27:1115-1122(2007) GeneRIF 123 · Mapped (17)
the metallothionein genes adipophilin (ADFP) CD36 adipocyte fatty acid binding protein (FABP4) ATP binding cassette protein A1 (ABCA1) and liver X receptor (LXR[alpha] GeneRIF 123

Nuotio K., Isoviita P.M., Saksi J., Ijas P., Pitkaniemi J., Sonninen R., Soinne L., Saimanen E., Salonen O., Kovanen P.T. et al.

Stroke 38:1791-1798(2007) GeneRIF 123 · Mapped (7)
Because adipophilin blocks cholesterol efflux from lipid-laden cells they may die and develop a necrotic lipid core thereby destabilizing the symptomatic carotid plaque. GeneRIF 123

Llorente-Cortes V., Royo T., Juan-Babot O., Badimon L.

J. Lipid Res. 48:2133-2140(2007) GeneRIF 123 · Mapped (15)
agLDL-LRP1 engagement induces adipocyte differentiation-related protein overexpression in both monocyte-derived macrophages and human vascular smooth muscle cells GeneRIF 123

Persson J., Degerman E., Nilsson J., Lindholm M.W.

Biochem. Biophys. Res. Commun. 363:1020-1026(2007) GeneRIF 123 · Mapped (8)
Perilipin content decreased and adipophilin increased with lipoprotein lipid loading regardless of intracellular neutral lipid composition GeneRIF 123

Daiger S.P., Sullivan L.S., Gire A.I., Birch D.G., Heckenlively J.R., Bowne S.J.

Adv. Exp. Med. Biol. 613:203-209(2008) GeneRIF 123 · Mapped (7)
Mutations in known genes account for 58% of autosomal dominant retinitis pigmentosa (adRP). GeneRIF 123

Straub B.K., Stoeffel P., Heid H., Zimbelmann R., Schirmacher P.

Hepatology 47:1936-1946(2008) GeneRIF 123 · Mapped (21)
Adipophilin and TIP47 are expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes. GeneRIF 123

Imanishi Y., Sun W., Maeda T., Maeda A., Palczewski K.

J. Biol. Chem. 283:25091-25102(2008) GeneRIF 123 · Mapped (26)
ADFP is involved in retinoid storage and trafficking in the mouse eye. GeneRIF 123

Collot-Teixeira S., Barbatis C., Bultelle F., Koutouzis M., Pasterkamp G., Fraser P., Kyriakides Z.S., Poston R.N., Ristagno A., McGregor L. et al.

J. Biomed. Biotechnol. 2008:813236-813236(2008) GeneRIF 123 · Mapped (22)
Increased expression by OxLDL in PMA-differentiated THP-1 macrophages and in plaque vs. nonplaque lesion areas in human carotid endarterectomy specimens (it(correlated with CD36 expression). GeneRIF 123

Urahama Y., Ohsaki Y., Fujita Y., Maruyama S., Yuzawa Y., Matsuo S., Fujimoto T.

Am. J. Pathol. 173:1286-1294(2008) GeneRIF 123 · Mapped (8)
The present results suggest that lipid droplets (LD) and LD-associated proteins have protective effects against apoptosis induced by fatty acid-bound albumin by sequestering free fatty acids. GeneRIF 123

Tanigawa K., Suzuki K., Nakamura K., Akama T., Kawashima A., Wu H., Hayashi M., Takahashi S., Ikuyama S., Ito T. et al.

FEMS Microbiol. Lett. 289:72-79(2008) GeneRIF 123 · Mapped (8)
Mycobacterium leprae regulates ADRP/perilipin expression to facilitate the accumulation of lipids within infected macrophages for intracellular survival. GeneRIF 123

Minnaard R., Schrauwen P., Schaart G., Jorgensen J.A., Lenaers E., Mensink M., Hesselink M.K.

J. Clin. Endocrinol. Metab. 94:4077-4085(2009) GeneRIF 123 · Mapped (8)
ADRP content was negatively associated with insulin-stimulated glucose uptake. Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes. GeneRIF 123