uniprot:Q99152 in citationmapping

14 results for uniprot:Q99152 in citationmapping

Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. Danen-van Oorschot A.A.M.M., Voskamp P., Seelen M.C.M.J., van Miltenburg M.H.A.M., Bolk M.W., Tait S.W., Boesen-de Cock J.G.R., Rohn J.L., Borst J., Noteborn M.H.M. Cell Death Differ. 11:564-573(2004) GeneRIF 1494446 · UniProtKB (2) · Mapped (4) Apoptin a protein from chicken anemia virus without an apparent cellular homologue can induce apoptosis in mammalian cells. Its cytotoxicity is limited to transformed or tumor cells. GeneRIF 1494446
Apoptin induces chromatin condensation in normal cells. He X., Zhang Q., Liu Y., He P. Virus Genes 31:49-55(2005) GeneRIF 1494446 · Mapped (4) Apoptin induces chromatin condensation when it is expressed in the nucleus and in the cytoplasm. GeneRIF 1494446
Mechanism of apoptin-induced apoptosis of human lymphoma cells U937. Ben S.B., Zhao H.L., Nie J., Li H.Y. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 21:527-529(2005) GeneRIF 1494446 · Mapped (4) role of c-Jun N-terminal kinase (JNK) in the apoptosis induced by apoptin gene in human lymphoma cell U937 GeneRIF 1494446
Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Liu X., Elojeimy S., El-Zawahry A.M., Holman D.H., Bielawska A., Bielawski J., Rubinchik S., Guo G.W., Dong J.Y., Keane T. et al. Mol. Ther. 14:637-646(2006) GeneRIF 1494446 · Mapped (4) Apoptin expression caused an increase in the tumor suppressor lipid ceramide which regulates the cellular stress response GeneRIF 1494446
Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. Janssen K., Hofmann T.G., Jans D.A., Hay R.T., Schulze-Osthoff K., Fischer U. Oncogene 26:1557-1566(2007) GeneRIF 1494446 · Mapped (24) apoptin kills tumor cells independently of PML and sumoylation however the interaction of apoptin with PML and small ubiquitin-like modifier (SUMO) proteins might be relevant for chicken anemia virus replication GeneRIF 1494446
Involvement of sphingolipids in apoptin-induced cell killing. Liu X., Zeidan Y.H., Elojeimy S., Holman D.H., El-Zawahry A.M., Guo G.W., Bielawska A., Bielawski J., Szulc Z., Rubinchik S. et al. Mol. Ther. 14:627-636(2006) GeneRIF 1494446 · Mapped (4) suggest that apoptin modulates ceramide/sphingolipid metabolism as part of its mechanism of action GeneRIF 1494446
Anti-neoplastic effect of chicken anemia virus VP3 protein (apoptin) in Rous sarcoma virus-induced tumours in chicken. Natesan S., Kataria J.M., Dhama K., Bhardwaj N., Sylvester A. J. Gen. Virol. 87:2933-2940(2006) GeneRIF 1494446 · Mapped (4) apoptin had an anti-neoplastic effect in vivo and in vitro in RSV-induced tumours GeneRIF 1494446
Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity. Lee Y.H., Cheng C.M., Chang Y.F., Wang T.Y., Yuo C.Y. Biochem. Biophys. Res. Commun. 354:391-395(2007) GeneRIF 1494446 · Mapped (4) T108 phosphorylation may only be required for the apoptotic activity mediated through the C-terminal apoptosis domain. GeneRIF 1494446
Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death. Maddika S., Bay G.H., Kroczak T.J., Ande S.R., Maddika S., Wiechec E., Gibson S.B., Los M. Cell Prolif. 40:835-848(2007) GeneRIF 1494446 · Mapped (11) PI3-K/Akt pathways have a dual role in both survival and cell death processes depending on the stimulus. GeneRIF 1494446
Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells. Huo D.H., Yi L.N., Yang J. Biochem. Biophys. Res. Commun. 372:14-18(2008) GeneRIF 1494446 · Mapped (7) Human peptidyl-prolyl isomerase-like 3 (Ppil3) is one of the Apoptin-associated proteins. GeneRIF 1494446
The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module. Kuusisto H.V., Wagstaff K.M., Alvisi G., Jans D.A. Int. J. Cancer 123:2965-2969(2008) GeneRIF 1494446 · Mapped (4) C-terminus of apoptin (residues 74-121) is sufficient for tumor cell-enhanced nuclear targeting through phosphoinhibition of apoptin (74-121)-mediated nuclear export occurring exclusively in tumor cells. GeneRIF 1494446
Replication of chicken anemia virus (CAV) requires apoptin and is complemented by VP3 of human torque teno virus (TTV). Prasetyo A.A., Kamahora T., Kuroishi A., Murakami K., Hino S. Virology 385:85-92(2009) GeneRIF 1494446 · Mapped (4) apoptin is necessary not only for DNA replication but also virus-like particle production of chicken anemia virus GeneRIF 1494446
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Maddika S., Panigrahi S., Wiechec E., Wesselborg S., Fischer U., Schulze-Osthoff K., Los M. Mol. Cell. Biol. 29:1235-1248(2009) GeneRIF 1494446 · Mapped (11) the pathway of apoptin-induced apoptosis and show that it essentially depends on abnormal phosphatidylinositol 3-kinase (PI3-kinase)/Akt activation resulting in the activation of the cyclin-dependent kinase CDK2 GeneRIF 1494446
Apoptin, a tumor-selective killer. Los M., Panigrahi S., Rashedi I., Mandal S., Stetefeld J., Essmann F., Schulze-Osthoff K. Biochim. Biophys. Acta 1793:1335-1342(2009) GeneRIF 1494446 · Mapped (4) Apoptin specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Review. GeneRIF 1494446