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Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase.

Sobhany M., Dong J., Negishi M.

J. Biol. Chem. 280:23441-23445(2005) GeneRIF 2135 · Mapped (7)
donor binding appears to undergo two distinct steps beginning with the N-acetyl group expelling water from the donor- enzyme complex into the bulk solvent followed by positioning of the donor into the binding site for interactions with the enzyme GeneRIF 2135

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