Wonsey D.R., Zeller K.I., Dang C.V.

Proc. Natl. Acad. Sci. U.S.A. 99:6649-6654(2002) GeneRIF 11757 · Mapped (9)
PRDX3 is a c-Myc target gene that is required to maintain normal mitochondrial function. c-Myc directly activates expression of a mitochondrial peroxiredoxin that is required for Myc-mediated transformation. GeneRIF 11757

Nonn L., Berggren M., Powis G.

Mol. Cancer Res. 1:682-689(2003) GeneRIF 11757 · Mapped (3)
mitochondrial Prdx3 is an important cellular antioxidant that regulates physiological levels of H(2)O(2) GeneRIF 11757

Li L., Shoji W., Takano H., Nishimura N., Aoki Y., Takahashi R., Goto S., Kaifu T., Takai T., Obinata M.

Biochem. Biophys. Res. Commun. 355:715-721(2007) GeneRIF 11757 · Mapped (3)
Roles of MER5 function for the oxidative stress responses by intratracheal inoculation of lipopolysaccharide (LPS) to the mice were examined. GeneRIF 11757

Barati M.T., Merchant M.L., Kain A.B., Jevans A.W., McLeish K.R., Klein J.B.

Am. J. Physiol. Renal Physiol. 293:F1157-65(2007) GeneRIF 11757 · Mapped (7)
Expression of 40 proteins including the antioxidative enzymes peroxiredoxin 1 and 3 glutathione peroxidase 1 and SOD-1 was increased with diabetes suggesting an adaptive response to oxidative stress associated with this diabetic model. GeneRIF 11757

Onorato T.M., Brown P.W., Morris P.L.

J. Androl. 29:293-303(2008) GeneRIF 11757 · Mapped (3)
significantly increased following 200 microM mono-(2-ethylhexyl) phthalate treatment GeneRIF 11757

Reinartz M., Ding Z., Flogel U., Godecke A., Schrader J.

J. Biol. Chem. 283:17440-17449(2008) GeneRIF 11757 · Mapped (3)
Nitrosative stress leads to protein glutathiolation increased s-nitrosation and up-regulation of Prx VI but not Prx II or Prx III in the heart GeneRIF 11757

Li L., Shoji W., Oshima H., Obinata M., Fukumoto M., Kanno N.

FEBS Lett. 582:2431-2434(2008) GeneRIF 11757 · Mapped (11)
Increased oxidative stress in placentas that were deficient in PrxIII. GeneRIF 11757

Bae S.H., Woo H.A., Sung S.H., Lee H.E., Lee S.K., Kil I.S., Rhee S.G.

Antioxid. Redox Signal. 11:937-948(2009) GeneRIF 11757 · Mapped (5)
Hyperoxia induced the degradation of Prx III in Nrf2-deficient mice but not in wild-type animals suggesting that in the absence of a sufficient amount of Srx GeneRIF 11757

Li L., Kaifu T., Obinata M., Takai T.

J. Biochem. 145:425-427(2009) GeneRIF 11757 · Mapped (3)
PrxIII is necessary for macrophages to protect against lipopolysaccharide-induced oxidative stress. GeneRIF 11757

Kumar V., Kitaeff N., Hampton M.B., Cannell M.B., Winterbourn C.C.

FEBS Lett. 583:997-1000(2009) GeneRIF 11757 · Mapped (3)
Local antioxidant activity of peroxiredoxin 3 may have a role in maintaining cardiac function. GeneRIF 11757

Li L., Obinata M., Hori K.

Oxid Med Cell Longev 3:71-73(2010) GeneRIF 11757 · Mapped (3)
Results indicate that PrxIII is not involved in pre-eclamptic development. Instead PrxIII is an indispensable antioxidant in placentas where oxidative stress exists. GeneRIF 11757

Wolf G., Aumann N., Michalska M., Bast A., Sonnemann J., Beck J.F., Lendeckel U., Newsholme P., Walther R.

J. Endocrinol. 207:163-175(2010) GeneRIF 11757 · Mapped (3)
This study showed that peroxiredoxin 3 protects pancreatic beta cells from cell stress induced by accumulation of hydrogen peroxide or the induction of inducible nitric oxide synthase or caspase-9 and -3 by pro-inflammatory cytokines or streptozotocin. GeneRIF 11757

Hanschmann E.M., Lonn M.E., Schutte L.D., Funke M., Godoy J.R., Eitner S., Hudemann C., Lillig C.H.

J. Biol. Chem. 285:40699-40705(2010) GeneRIF 11757 · Mapped (18)
Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3. GeneRIF 11757

Godoy J.R., Oesteritz S., Hanschmann E.M., Ockenga W., Ackermann W., Lillig C.H.

Free Radic. Biol. Med. 51:552-561(2011) GeneRIF 11757 · Mapped (8)
Immunohistochemical analysis revealed segment-specific alterations induced by the ischemic insult. Grx2 Prx3 and Prx6 were highly expressed in proximal tubule cells GeneRIF 11757

Huh J.Y., Kim Y., Jeong J., Park J., Kim I., Huh K.H., Kim Y.S., Woo H.A., Rhee S.G., Lee K.J. et al.

Antioxid. Redox Signal. 16:229-243(2012) GeneRIF 11757 · Mapped (3)
endogenous Prx3 may play an essential role in maintaining normal characteristics of adipocytes and that defect in Prx3 alters mitochondrial redox state and function. GeneRIF 11757

Bae S.H., Sung S.H., Lee H.E., Kang H.T., Lee S.K., Oh S.Y., Woo H.A., Kil I.S., Rhee S.G.

Antioxid. Redox Signal. 17:1351-1361(2012) GeneRIF 11757 · Mapped (7)
The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria. GeneRIF 11757

Kil I.S., Lee S.K., Ryu K.W., Woo H.A., Hu M.C., Bae S.H., Rhee S.G.

Mol. Cell 46:584-594(2012) GeneRIF 11757 · Mapped (3)
PrxIII in mouse adrenal cortex is inactivated by H(2)O(2) produced by cytochrome P450 enzymes during corticosterone production stimulated by adrenocorticotropic hormone. GeneRIF 11757