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4 results for uniprot:Q8IWJ2 in Computationally mapped citations

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The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.

Luke M.R., Houghton F., Perugini M.A., Gleeson P.A.

Biochem. J. 388:835-841(2005) GeneRIF 9648 · Mapped (18)
The ability of the four mammalian GRIP domain proteins p230 golgin-97 GCC88 and GCC185 to interact is reported. GeneRIF 9648

Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.

Hayes G.L., Brown F.C., Haas A.K., Nottingham R.M., Barr F.A., Pfeffer S.R.

Mol. Biol. Cell 20:209-217(2009) GeneRIF 9648 · Mapped (4)
Results show that GCC185 contains at least six binding sites for as many as 14 different Rab GTPases across its entire length. GeneRIF 9648

GCC185 plays independent roles in Golgi structure maintenance and AP-1-mediated vesicle tethering.

Brown F.C., Schindelhaim C.H., Pfeffer S.R.

J. Cell Biol. 194:779-787(2011) GeneRIF 9648 · Mapped (4)
Two distinct domains of GCC185 are needed either for Golgi structure maintenance or transport vesicle tethering. The domain needed for vesicle tethering binds to the clathrin adaptor AP-1. GeneRIF 9648

ARL4A acts with GCC185 to modulate Golgi complex organization.

Lin Y.C., Chiang T.C., Liu Y.T., Tsai Y.T., Jang L.T., Lee F.J.

J. Cell. Sci. 124:4014-4026(2011) GeneRIF 9648 · Mapped (5)
Deletion of the ARL4A-interacting region of GCC185 results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport. GeneRIF 9648

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