uniprot:Q8BFP9 in citationmapping

1 - 25 of 36 results for uniprot:Q8BFP9 in citationmapping

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure. Mora A., Lipina C., Tronche F., Sutherland C., Alessi D.R. Biochem. J. 385:639-648(2005) GeneRIF 228026 · Mapped (10) a deficiency of the PDK1 pathway in the liver could contribute to development of diabetes as well as to liver failure GeneRIF 228026
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Bayascas J.R., Leslie N.R., Parsons R., Fleming S., Alessi D.R. Curr. Biol. 15:1839-1846(2005) GeneRIF 228026 · Mapped (15) PDK1 is a key effector in mediating neoplasia resulting from loss of PTEN and is a promising anticancer target for the prevention of tumors that possess elevated PKB and S6K activity. GeneRIF 228026
Fine tuning PDK1 activity by phosphorylation at Ser163. Riojas R.A., Kikani C.K., Wang C., Mao X., Zhou L., Langlais P.R., Hu D., Roberts J.L., Dong L.Q., Liu F. J. Biol. Chem. 281:21588-21593(2006) GeneRIF 228026 · Mapped (4) PDK1 undergoes insulin-stimulated and phosphatidylinositol 3-kinase-dependent phosphorylation at Ser244 in the activation loop and at a novel site: Ser163 in the hinge region between the two lobes of the kinase domain. GeneRIF 228026
Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice. Rexhepaj R., Grahammer F., Volkl H., Remy C., Wagner C.A., Sandulache D., Artunc F., Henke G., Nammi S., Capasso G. et al. FASEB J. 20:2214-2222(2006) GeneRIF 228026 · Mapped (10) Reduction of functional PDK1 leads to impairment of intestinal absorption and renal reabsorption of amino acids. GeneRIF 228026
Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1. Okamoto Y., Ogawa W., Nishizawa A., Inoue H., Teshigawara K., Kinoshita S., Matsuki Y., Watanabe E., Hiramatsu R., Sakaue H. et al. Diabetes 56:1000-1009(2007) GeneRIF 228026 · Mapped (10) The hepatic abundance of glucokinase is reduced in Phosphoinositide-dependent kinase-1 deficient mice. GeneRIF 228026
Reduced Ca2+ entry and suicidal death of erythrocytes in PDK1 hypomorphic mice. Foller M., Mahmud H., Koka S., Lang F. Pflugers Arch. 455:939-949(2008) GeneRIF 228026 · Mapped (4) PDK1 deficiency is associated with decreased Ca2+ entry into erythrocytes and thus with blunted eryptotic effects of oxidative stress osmotic shock and Cl- removal GeneRIF 228026
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. Weisberg E., Banerji L., Wright R.D., Barrett R., Ray A., Moreno D., Catley L., Jiang J., Hall-Meyers E., Sauveur-Michel M. et al. Blood 111:3723-3734(2008) GeneRIF 228026 · Mapped (19) Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. GeneRIF 228026
PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Belgardt B.F., Husch A., Rother E., Ernst M.B., Wunderlich F.T., Hampel B., Klockener T., Alessi D., Kloppenburg P., Bruning J.C. Cell Metab. 7:291-301(2008) GeneRIF 228026 · Mapped (16) mice with inactivated PDK1 in POMC-expressing cells display hyperphagia increased body weight and impaired glucose metabolism from reduced hypothalamic POMC expression and exhibit hypocortisolism from loss of POMC-expressing corticotrophs in pituitary. GeneRIF 228026
PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression. Nakamura K., Sakaue H., Nishizawa A., Matsuki Y., Gomi H., Watanabe E., Hiramatsua R., Tamamori-Adachi M., Kitajima S., Noda T. et al. J. Biol. Chem. 283:17702-17711(2008) GeneRIF 228026 · Mapped (20) PDK1 plays an important role in cell proliferation and cell cycle progression by controlling the expression of both cyclin D1 and p27(Kip1) GeneRIF 228026
Loss of polycystin-1 causes centrosome amplification and genomic instability. Battini L., Macip S., Fedorova E., Dikman S., Somlo S., Montagna C., Gusella G.L. Hum. Mol. Genet. 17:2819-2833(2008) GeneRIF 228026 · Mapped (13) Centrosome amplification occurs in kidneys from conditional Pkd1 knockout mice and in human autosomal dominant polycystic kidney disease patients. GeneRIF 228026
Serine 396 of PDK1 is required for maximal PKB activation. Moon Z., Wang Y., Aryan N., Mousseau D.D., Scheid M.P. Cell. Signal. 20:2038-2049(2008) GeneRIF 228026 · Mapped (7) Serine396 plays a role in the activation of PKB leading to the regulated phosphorylation of some PKB substrates including FOXO3alpha. GeneRIF 228026
The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells. Park S.G., Schulze-Luehrman J., Hayden M.S., Hashimoto N., Ogawa W., Kasuga M., Ghosh S. Nat. Immunol. 10:158-166(2009) GeneRIF 228026 · Mapped (18) CD28 facilitated NF-kappaB activation by regulating recruitment and phosphorylation of PDK1 in murine t-cells GeneRIF 228026
Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells. Raphael K.L., Strait K.A., Stricklett P.K., Miller R.L., Nelson R.D., Piontek K.B., Germino G.G., Kohan D.E. Kidney Int. 75:626-633(2009) GeneRIF 228026 · Mapped (4) Pkd1 deleted in the principal cells led to progressive cystic kidney disease while Pkd1 deleted in the intercalated cells had a very mild cystic phenotype GeneRIF 228026
PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1. Xia S., Chen Z., Forman L.W., Faller D.V. Cell. Signal. 21:502-508(2009) GeneRIF 228026 · Mapped (42) p21(Ras)-mediated survival signaling is regulated by via a PI(3)K-AKT pathway which is dependent upon both PDK1 and PKCdelta and PDK1 activates and regulates PKCdelta to determine the fate of cells containing a mutated activated p21(Ras). GeneRIF 228026
PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles. Reddy P., Adhikari D., Zheng W., Liang S., Hamalainen T., Tohonen V., Ogawa W., Noda T., Volarevic S., Huhtaniemi I. et al. Hum. Mol. Genet. 18:2813-2824(2009) GeneRIF 228026 · Mapped (10) PDK1 in oocytes is required to maintain the survival of primordial follicles. GeneRIF 228026
A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1. Rodriguez O.C., Lai E.W., Vissapragada S., Cromelin C., Avetian M., Salinas P., Ramos H., Kallakury B., Casimiro M., Lisanti M.P. et al. Am. J. Pathol. 174:2051-2060(2009) GeneRIF 228026 · Mapped (29) Pten functions downstream of ErbB-2 to restrict prostate epithelial transformation by blocking full activation of the PDK1 signaling cascade. GeneRIF 228026
Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1. Oishi K., Watatani K., Itoh Y., Okano H., Guillemot F., Nakajima K., Gotoh Y. Proc. Natl. Acad. Sci. U.S.A. 106:13064-13069(2009) GeneRIF 228026 · Mapped (49) Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1. GeneRIF 228026
Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains. Chalhoub N., Zhu G., Zhu X., Baker S.J. Genes Dev. 23:1619-1624(2009) GeneRIF 228026 · Mapped (22) deletion of Pdk1 caused microcephaly and Pdk1 inactivation induced strikingly different effects on the regulation of phosphorylated Akt in glia versus neurons GeneRIF 228026
Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling. Zhang Y., Shumilina E., Haring H.U., Lang F., Ullrich S. FEBS Lett. 583:3101-3106(2009) GeneRIF 228026 · Mapped (10) The hyperpolarizing effect of epinephrine in pancreatic islet cells is sensitive to PI3K and PDK1. GeneRIF 228026
Functional annotation of a full-length mouse cDNA collection. Kawai J., Shinagawa A., Shibata K., Yoshino M., Itoh M., Ishii Y., Arakawa T., Hara A., Fukunishi Y., Konno H. et al. Nature 409:685-690(2001) MGI 1926119 · UniProtKB (17,855) · Mapped (8,931)
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., Nikaido I., Osato N., Saito R., Suzuki H. et al. Nature 420:563-573(2002) MGI 1926119 · UniProtKB (17,858) · Mapped (12,469)
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J., Floss T., Van Sloun P., Fuchtbauer E.M., Vauti F., Arnold H.H., Schnutgen F., Wurst W., von Melchner H., Ruiz P. Proc. Natl. Acad. Sci. U.S.A. 100:9918-9922(2003) MGI 1926119 · Mapped (6,193)
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz B.P., Abuin A., Ramirez-Solis R., Richter L.J., Piggott J., BeltrandelRio H., Buxton E.C., Edwards J., Finch R.A., Friddle C.J. et al. Proc. Natl. Acad. Sci. U.S.A. 100:14109-14114(2003) MGI 1926119 · Mapped (17,104)
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha V.K., Bunkenborg J., Olsen J.V., Hjerrild M., Wisniewski J.R., Stahl E., Bolouri M.S., Ray H.N., Sihag S., Kamal M. et al. Cell 115:629-640(2003) MGI 1926119 · UniProtKB (15) · Mapped (987)
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A., Thaller C., Eichele G. Nucleic Acids Res. 32:D552-D556(2004) MGI 1926119 · UniProtKB (1) · Mapped (1,707)