Ohashi S., Kanai M., Hanai S., Uchiumi F., Maruta H., Tanuma S., Miwa M.

Biochem. Biophys. Res. Commun. 307:915-921(2003) GeneRIF 8505 · Mapped (5)
Subcellular localization of human poly(ADP-ribose) glycohydrolase in mammalian cells. GeneRIF 8505

Bonicalzi M.E., Haince J.F., Droit A., Poirier G.G.

Cell. Mol. Life Sci. 62:739-750(2005) GeneRIF 8505 · Mapped (5)
PARG in modulating chromatin structure participares in transcription DNA repair and apoptosis [review] GeneRIF 8505

Gagne J.P., Bonicalzi M.E., Gagne P., Ouellet M.E., Hendzel M.J., Poirier G.G.

Biochem. J. 392:499-509(2005) GeneRIF 8505 · Mapped (13)
PARG is resident in FMRP (Fragile-X mental retardation protein)-associated messenger ribonucleoparticles complexes. GeneRIF 8505

Blenn C., Althaus F.R., Malanga M.

Biochem. J. 396:419-429(2006) GeneRIF 8505 · Mapped (14)
results suggest that PARG may play an autonomous role in the cellular response to oxidative DNA damage GeneRIF 8505

Fisher A.E., Hochegger H., Takeda S., Caldecott K.W.

Mol. Cell. Biol. 27:5597-5605(2007) GeneRIF 8505 · Mapped (13)
PARG is identified as a novel and critical component of single-strand break repair that accelerates this process in concert with PARP-1. GeneRIF 8505

Zhou Y.M., Wen Y.H., Kang X.Y., Qian H.H., Yang J.M., Yin Z.F.

World J. Gastroenterol. 14:2168-2173(2008) GeneRIF 8505 · Mapped (5)
PPAR gamma ligands inhibit growth and induce apoptosis of liver cancer cell GeneRIF 8505

Skibola C.F., Bracci P.M., Halperin E., Nieters A., Hubbard A., Paynter R.A., Skibola D.R., Agana L., Becker N., Tressler P. et al.

PLoS ONE 3:e2816-e2816(2008) GeneRIF 8505 · Mapped (988)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8505

Uchiumi F., Sakakibara G., Sato J., Tanuma S.

Genes Cells 13:1229-1247(2008) GeneRIF 8505 · Mapped (7)
suggest that PU.1-binding motifs are essential for PARG promoter activity and that PU.1 modulates PARG gene expression during differentiation of HL-60 cells. GeneRIF 8505

Whatcott C.J., Meyer-Ficca M.L., Meyer R.G., Jacobson M.K.

Exp. Cell Res. 315:3477-3485(2009) GeneRIF 8505 · Mapped (5)
The identification of a PARG isoform as a component of the mitochondrial matrix raises several interesting possibilities concerning mechanisms of nuclear-mitochondrial cross talk involved in regulation of cell death pathways. GeneRIF 8505

Ame J.C., Fouquerel E., Gauthier L.R., Biard D., Boussin F.D., Dantzer F., de Murcia G., Schreiber V.

J. Cell. Sci. 122:1990-2002(2009) GeneRIF 8505 · Mapped (5)
PARG could be a novel potential therapeutic target for radiotherapy. GeneRIF 8505

Erdelyi K., Bai P., Kovacs I., Szabo E., Mocsar G., Kakuk A., Szabo C., Gergely P., Virag L.

FASEB J. 23:3553-3563(2009) GeneRIF 8505 · Mapped (5)
These data indicate that PARG is a survival factor at mild oxidative damage but contributes to the apoptosis-necrosis switch in severely damaged cells. GeneRIF 8505

Frizzell K.M., Gamble M.J., Berrocal J.G., Zhang T., Krishnakumar R., Cen Y., Sauve A.A., Kraus W.L.

J. Biol. Chem. 284:33926-33938(2009) GeneRIF 8505 · Mapped (13)
PARP-1 and PARG nuclear enzymes with opposing enzymatic activities localize to target promoters and act in a similar rather than antagonistic manner to regulate gene expression GeneRIF 8505

Fathers C., Drayton R.M., Solovieva S., Bryant H.E.

Cell Cycle 11:990-997(2012) GeneRIF 8505 · Mapped (5)
inhibition of PARG leads to an accumulation of PAR polymers the collapse of replication forks and the induction of homologous recombination in wild-type cells. GeneRIF 8505

Li Q., Li M., Wang Y.L., Fauzee N.J., Yang Y., Pan J., Yang L., Lazar A.

Cell. Physiol. Biochem. 29:361-372(2012) GeneRIF 8505 · Mapped (10)
PARG knockdown concomitant with inhibition of PARP suppressed the metastatic potency of colon carcinoma cells by activation of PI3K/Akt signaling pathway. GeneRIF 8505

Tucker J.A., Bennett N., Brassington C., Durant S.T., Hassall G., Holdgate G., McAlister M., Nissink J.W., Truman C., Watson M.

PLoS ONE 7:e50889-e50889(2012) PDB 4A0D · Mapped (1)