Li M., Chen D., Shiloh A., Luo J., Nikolaev A.Y., Qin J., Gu W.

Nature 416:648-653(2002) GeneRIF 7874 · UniProtKB (1) · Mapped (37)
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization GeneRIF 7874

Holowaty M.N., Sheng Y., Nguyen T., Arrowsmith C., Frappier L.

J. Biol. Chem. 278:47753-47761(2003) GeneRIF 7874 · UniProtKB (3) · Mapped (6)
analysis of protein interaction domains of the ubiquitin-specific protease USP7/HAUSP GeneRIF 7874

Li M., Brooks C.L., Kon N., Gu W.

Mol. Cell 13:879-886(2004) GeneRIF 7874 · Mapped (7)
HAUSP regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. GeneRIF 7874

Cummins J.M., Rago C., Kohli M., Kinzler K.W., Lengauer C., Vogelstein B.

Nature 428:1 p following 2004:486-486(2004) GeneRIF 7874 · Mapped (38)
the net deubiquitination of the various targets of HAUSP determines the steady-state level of p53 GeneRIF 7874

Holowaty M.N., Frappier L.

Biochem. Soc. Trans. 32:731-732(2004) GeneRIF 7874 · Mapped (7)
USP7 is an Epstein-Barr virus target [review] GeneRIF 7874

Saridakis V., Sheng Y., Sarkari F., Holowaty M.N., Shire K., Nguyen T., Zhang R.G., Liao J., Lee W., Edwards A.M. et al.

Mol. Cell 18:25-36(2005) GeneRIF 7874 · UniProtKB (2) · Mapped (37)
crystal structure of the p53 binding domain of USP7 alone and bound to an EBNA1 peptide GeneRIF 7874

Meulmeester E., Maurice M.M., Boutell C., Teunisse A.F., Ovaa H., Abraham T.E., Dirks R.W., Jochemsen A.G.

Mol. Cell 18:565-576(2005) GeneRIF 7874 · Mapped (33)
Results suggest that impaired deubiquitination of Hdmx/Hdm2 by HAUSP contributes to the DNA damage-induced degradation of Hdmx and transient instability of Hdm2. GeneRIF 7874

Yoo K.J., Lee H.J., Lee H., Lee K.Y., Lee S.H., Chung H.M., Baek K.H.

Int. J. Oncol. 27:97-104(2005) GeneRIF 7874 · Mapped (9)
HAUSP regulates apoptosis of cervical adenocarcinoma cells GeneRIF 7874

Boutell C., Canning M., Orr A., Everett R.D.

J. Virol. 79:12342-12354(2005) GeneRIF 7874 · Mapped (7)
ICP0 targets USP7 for ubiquitination and proteasome-dependent degradation; concluded that USP7-mediated stabilization of ICP0 is dominant over ICP0-induced degradation of USP7 during productive HSV-1 infection GeneRIF 7874

Sheng Y., Saridakis V., Sarkari F., Duan S., Wu T., Arrowsmith C.H., Frappier L.

Nat. Struct. Mol. Biol. 13:285-291(2006) GeneRIF 7874 · UniProtKB (3) · Mapped (61)
N-terminal domain of USP7 binds two closely spaced 4-residue sites in both p53 and MDM2 falling between p53 residues 359-367 and MDM2 residues 147-159. GeneRIF 7874

Oh Y.M., Yoo S.J., Seol J.H.

Biochem. Biophys. Res. Commun. 357:615-619(2007) GeneRIF 7874 · Mapped (9)
Finding suggests that USP7-mediated deubiquitination of Chfr leads to its accumulation which might be a key regulatory step for Chfr activation. GeneRIF 7874

Fernandez-Montalvan A., Bouwmeester T., Joberty G., Mader R., Mahnke M., Pierrat B., Schlaeppi J.M., Worpenberg S., Gerhartz B.

FEBS J. 274:4256-4270(2007) GeneRIF 7874 · Mapped (7)
Data suggest that interaction partners might be required for USP7 nuclear import. GeneRIF 7874

Kessler B.M., Fortunati E., Melis M., Pals C.E., Clevers H., Maurice M.M.

J. Proteome Res. 6:4163-4172(2007) GeneRIF 7874 · Mapped (7)
USP7 may have a role not only in transcriptional regulation but also in DNA replication apoptosis and possibly endosomal organization GeneRIF 7874

Nathan J.A., Sengupta S., Wood S.A., Admon A., Markson G., Sanderson C., Lehner P.J.

Traffic 9:1130-1145(2008) GeneRIF 7874 · Mapped (15)
MARCH7 can be stabilized by both USP9X and USP7 which deubiquitylate MARCH7 in the cytosol and nucleus respectively GeneRIF 7874

Becker K., Marchenko N.D., Palacios G., Moll U.M.

Cell Cycle 7:1205-1213(2008) GeneRIF 7874 · Mapped (7)
Our data suggest that changes in HAUSP modulate tumor growth and apoptotic sensitivity in vivo. GeneRIF 7874

Song M.S., Song S.J., Kim S.Y., Oh H.J., Lim D.S.

EMBO J. 27:1863-1874(2008) GeneRIF 7874 · Mapped (51)
RASSF1A associates with MDM2 and death-domain-associated protein (DAXX) in the nucleus thereby disrupting the interactions between MDM2 DAXX and the deubiquitinase HAUSP and enhancing the self-ubiquitin ligase activity of MDM2. GeneRIF 7874

Antrobus R., Boutell C.

Virus Res. 137:64-71(2008) GeneRIF 7874 · Mapped (7)
Herpes simplex virus type-1 immediate early protein ICP0 can interact with a previously unidentified isoform of USP7 that is not a predominantly ubiquitinated SUMO-modified or phosphorylated but is expressed in a number of different cell types GeneRIF 7874

Song M.S., Salmena L., Carracedo A., Egia A., Lo-Coco F., Teruya-Feldstein J., Pandolfi P.P.

Nature 455:813-817(2008) GeneRIF 7874 · Mapped (31)
results delineate a previously unknown PML-DAXX-HAUSP molecular network controlling PTEN deubiquitinylation and trafficking which is perturbed by oncogenic cues in human cancer GeneRIF 7874

Sivachandran N., Sarkari F., Frappier L.

PLoS Pathog. 4:e1000170-e1000170(2008) GeneRIF 7874 · Mapped (58)
PML disruption by EBNA1 requires binding to the cellular ubiquitin specific protease USP7 or HAUSP but is independent of p53. GeneRIF 7874

Daubeuf S., Singh D., Tan Y., Liu H., Federoff H.J., Bowers W.J., Tolba K.

Blood 113:3264-3275(2009) GeneRIF 7874 · Mapped (7)
USP7 is part of a negative feedback loop regulating TLR signaling and that ICP0 exploits this physiologic process to attenuate innate response to HSV. GeneRIF 7874

Faustrup H., Bekker-Jensen S., Bartek J., Lukas J., Mailand N.

J. Cell Biol. 184:13-19(2009) GeneRIF 7874 · Mapped (7)
USP7 specifically opposes the SCF(betaTrCP)- but not APC(Cdh1)-mediated degradation of Claspin. GeneRIF 7874

Kang H.J., Feng Z., Sun Y., Atwal G., Murphy M.E., Rebbeck T.R., Rosenwaks Z., Levine A.J., Hu W.

Proc. Natl. Acad. Sci. U.S.A. 106:9761-9766(2009) GeneRIF 7874 · Mapped (76)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7874