Grupe A., Li Y., Rowland C., Nowotny P., Hinrichs A.L., Smemo S., Kauwe J.S., Maxwell T.J., Cherny S., Doil L. et al.

Am. J. Hum. Genet. 78:78-88(2006) GAD 586717 GeneRIF 3799 · Mapped (1,497)
Not Associated with NEUROLOGICAL: Alzheimer's disease ; GAD 586717 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3799

Hakimi M.A., Speicher D.W., Shiekhattar R.

J. Biol. Chem. 277:36909-36912(2002) GeneRIF 3799 · Mapped (17)
links neurofibromin and merlin in a common cellular pathway of neurofibromatosis GeneRIF 3799

Diefenbach R.J., Diefenbach E., Douglas M.W., Cunningham A.L.

Biochemistry 41:14906-14915(2002) GeneRIF 3799 · Mapped (25)
With residues 814-963 of human ubiquitous kinesin heavy chain (uKHC) used as bait a synaptosome-associated protein of 25 kDa (SNAP25) has been identified as a kinesin-binding protein in a human brain cDNA library. GeneRIF 3799

Diefenbach R.J., Diefenbach E., Douglas M.W., Cunningham A.L.

Biochem. Biophys. Res. Commun. 319:987-992(2004) GeneRIF 3799 · Mapped (14)
Results identify the ribosome receptor p180 as a binding partner of the kinesin heavy chain isoform KIF5B. GeneRIF 3799

Kawano Y., Yoshimura T., Tsuboi D., Kawabata S., Kaneko-Kawano T., Shirataki H., Takenawa T., Kaibuchi K.

Mol. Cell. Biol. 25:9920-9935(2005) GeneRIF 3799 · UniProtKB (2) · Mapped (15)
CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation GeneRIF 3799

Score J., Curtis C., Waghorn K., Stalder M., Jotterand M., Grand F.H., Cross N.C.

Leukemia 20:827-832(2006) GeneRIF 3799 · Mapped (8)
Demonstrates the utility of screening for PDGFRA kinase domain overexpression in patients with IHES and has identified KIF5B as a third PDGFRA fusion partner in chronic myeloproliferative disorders. GeneRIF 3799

Schepis A., Stauber T., Krijnse Locker J.

Cell. Microbiol. 9:1960-1973(2007) GeneRIF 3799 · Mapped (11)
kinesin-1 but not kinesin-2 contributes to the specific cytoplasmic distribution of three of the four steps of VV morphogenesis tested. GeneRIF 3799

Cho K.I., Cai Y., Yi H., Yeh A., Aslanukov A., Ferreira P.A.

Traffic 8:1722-1735(2007) GeneRIF 3799 · Mapped (19)
binding of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function GeneRIF 3799

Jaulin F., Xue X., Rodriguez-Boulan E., Kreitzer G.

Dev. Cell 13:511-522(2007) GeneRIF 3799 · Mapped (7)
We demonstrate that KIF5B mediates post-Golgi transport of an apical protein in epithelial cells but only after polarity has developed. GeneRIF 3799

Takahashi K., Suzuki K.

Exp. Cell Res. 314:2313-2322(2008) GeneRIF 3799 · Mapped (11)
Data suggest that the promotion of lamellipodia formation by HGF in MDA-MB-231 cells is Rac1-dependent and requires KIF5B-mediated transport of WAVE2 and IQGAP1 to the cell periphery along microtubules. GeneRIF 3799

Dietrich K.A., Sindelar C.V., Brewer P.D., Downing K.H., Cremo C.R., Rice S.E.

Proc. Natl. Acad. Sci. U.S.A. 105:8938-8943(2008) GeneRIF 3799 · Mapped (7)
The interaction of the Switch I region of the kinesin-1 head with the tail is strikingly similar to the interactions of small GTPases with their regulators indicating that other kinesin motors may share similar regulatory mechanisms. GeneRIF 3799

Gupta V., Palmer K.J., Spence P., Hudson A., Stephens D.J.

Traffic 9:1850-1866(2008) GeneRIF 3799 · Mapped (7)
data implicate kinesin-1 in the spatial organization of the ER/Golgi interface as well as in traffic outside the ER GeneRIF 3799

Argyropoulos G., Stutz A.M., Ilnytska O., Rice T., Teran-Garcia M., Rao D.C., Bouchard C., Rankinen T.

Physiol. Genomics 36:79-88(2009) GeneRIF 3799 · Mapped (60)
training-induced changes in submaximal exercise stroke volume may be due to mitochondrial function and variation in KIF5B expression as determined by functional SNPs in its promoter; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 3799

Cardoso C.M., Groth-Pedersen L., Hoyer-Hansen M., Kirkegaard T., Corcelle E., Andersen J.S., Jaattela M., Nylandsted J.

PLoS ONE 4:e4424-e4424(2009) GeneRIF 3799 · Mapped (7)
KIF5B is a cancer relevant lysosomal motor protein with additional functions in autophagosome formation GeneRIF 3799

Cho K.I., Yi H., Desai R., Hand A.R., Haas A.L., Ferreira P.A.

EMBO Rep. 10:480-486(2009) GeneRIF 3799 · Mapped (10)
RANBP2 is the first native and positive allosteric activator known to jump-start and boost directly the activity of KIF5B. GeneRIF 3799

Wong Y.L., Dietrich K.A., Naber N., Cooke R., Rice S.E.

Biophys. J. 96:2799-2807(2009) GeneRIF 3799 · Mapped (7)
the interaction between the kinesin-1 head and its regulatory tail domain GeneRIF 3799

Zadeh A.D., Cheng Y., Xu H., Wong N., Wang Z., Goonasekara C., Steele D.F., Fedida D.

J. Physiol. (Lond.) 587:4565-4574(2009) GeneRIF 3799 · Mapped (8)
role of the kinesin I isoform Kif5b in the trafficking of a cardiac voltage-gated potassium channel Kv1.5 in Kv1.5-expressing HEK293 cells and H9c2 cardiomyoblasts GeneRIF 3799

Trejo H.E., Lecuona E., Grillo D., Szleifer I., Nekrasova O.E., Gelfand V.I., Sznajder J.I.

FASEB J. 24:374-382(2010) GeneRIF 3799 · Mapped (8)
Na K-ATPase traffic toward the plasma membrane in alveolar epithelial cells is driven by kinesin-1 where KLC2 is the isoform regulating this process. GeneRIF 3799

Morton A.M., Cunningham A.L., Diefenbach R.J.

Biochem. Biophys. Res. Commun. 391:388-393(2010) GeneRIF 3799 · Mapped (8)
This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events. GeneRIF 3799

Seeger M.A., Rice S.E.

J. Biol. Chem. 285:8155-8162(2010) GeneRIF 3799 · Mapped (7)
a kinesin-1 tail fragment associates with microtubules with submicromolar affinity and binding is largely electrostatic GeneRIF 3799

Wong D.W., Leung E.L., Wong S.K., Tin V.P., Sihoe A.D., Cheng L.C., Au J.S., Chung L.P., Wong M.P.

Cancer 117:2709-2718(2011) GeneRIF 3799 · Mapped (25)
The discovery of the novel KIF5B-ALK variant further consolidated the role of aberrant anaplastic lymphoma kinase signaling in lung carcinogenesis. GeneRIF 3799

Li M., Zheng W.

Biochemistry 50:8645-8655(2011) GeneRIF 3799 · Mapped (17)
The conventional kinesin-microtubule binding free energy is dominated by van der Waals interactions and electrostatic interactions. GeneRIF 3799

Dodding M.P., Mitter R., Humphries A.C., Way M.

EMBO J. 30:4523-4538(2011) GeneRIF 3799 · Mapped (25)
findings show a bipartite tryptophan-based motif in vaccinia virus A36 is required for kinesin-1-dependent transport of the virus; bioinformatic analysis reveals that related bipartite tryptophan-based motifs are present in over 450 human proteins GeneRIF 3799

Rosa-Ferreira C., Munro S.

Dev. Cell 21:1171-1178(2011) GeneRIF 3799 · Mapped (17)
Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery. GeneRIF 3799

Cochran J.C., Zhao Y.C., Wilcox D.E., Kull F.J.

Nat. Struct. Mol. Biol. 19:122-127(2012) GeneRIF 3799 · Mapped (10)
Data indicate that mutant KIF5B kinesin-1 binds ATP similarly in the presence of either metal ion but its ATP hydrolysis activity is greatly diminished in the presence of Mg(2+). GeneRIF 3799