Min G., Kim H., Bae Y., Petz L., Kemper J.K.

J. Biol. Chem. 277:34626-34633(2002) GeneRIF 9970 · Mapped (25)
CAR antagonizes ER-mediated transcriptional activity by squelching limiting amounts of p160 coactivators such as SRC-1 and GRIP-1. GeneRIF 9970

Goodwin B., Hodgson E., D'Costa D.J., Robertson G.R., Liddle C.

Mol. Pharmacol. 62:359-365(2002) GeneRIF 9970 · Mapped (21)
Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. GeneRIF 9970

Ferguson S.S., LeCluyse E.L., Negishi M., Goldstein J.A.

Mol. Pharmacol. 62:737-746(2002) GeneRIF 9970 · Mapped (28)
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. GeneRIF 9970

Zhang J., Huang W., Chua S.S., Wei P., Moore D.D.

Science 298:422-424(2002) GeneRIF 9970 · Mapped (25)
identified as a key regulator of acetaminophen metabolism and hepatotoxicity GeneRIF 9970

Chang T.K., Bandiera S.M., Chen J.

Drug Metab. Dispos. 31:7-10(2003) GeneRIF 9970 · Mapped (29)
Substantial interindividual differences exist in hepatic constitutive androstane receptor expression; a 240-fold interindividual variability in hepatic mRNA levels has been detected. GeneRIF 9970

Pascussi J.M., Busson-Le Coniat M., Maurel P., Vilarem M.J.

Mol. Endocrinol. 17:42-55(2003) GeneRIF 9970 · Mapped (21)
A distal glucocorticoid response element located within the CAR promoter is described and evidence is presented that this element is capable of of conferring transcriptional activation via the glucocorticoid pathway. GeneRIF 9970

Shiraki T., Sakai N., Kanaya E., Jingami H.

J. Biol. Chem. 278:11344-11350(2003) GeneRIF 9970 · Mapped (24)
activation requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha GeneRIF 9970

Xie W., Yeuh M.F., Radominska-Pandya A., Saini S.P., Negishi Y., Bottroff B.S., Cabrera G.Y., Tukey R.H., Evans R.M.

Proc. Natl. Acad. Sci. U.S.A. 100:4150-4155(2003) GeneRIF 9970 · Mapped (33)
control of steroid heme and carcinogen metabolism by this protein in transgenic mice GeneRIF 9970

Huang W., Zhang J., Chua S.S., Qatanani M., Han Y., Granata R., Moore D.D.

Proc. Natl. Acad. Sci. U.S.A. 100:4156-4161(2003) GeneRIF 9970 · Mapped (25)
Induces bilirubin clearance when expressed in transgenic mice GeneRIF 9970

Auerbach S.S., Ramsden R., Stoner M.A., Verlinde C., Hassett C., Omiecinski C.J.

Nucleic Acids Res. 31:3194-3207(2003) GeneRIF 9970 · Mapped (21)
Alternatively spliced isoforms of the constitutive androstane receptor. GeneRIF 9970

Frank C., Gonzalez M.M., Oinonen C., Dunlop T.W., Carlberg C.

J. Biol. Chem. 278:43299-43310(2003) GeneRIF 9970 · Mapped (21)
CAR-RXR heterodimers and CAR monomers can contribute to the gene activating function of phenobarbital response enhancer modules in CAR target genes GeneRIF 9970

Frank C., Molnar F., Matilainen M., Lempiainen H., Carlberg C.

J. Biol. Chem. 279:33558-33566(2004) GeneRIF 9970 · Mapped (25)
stabilization of helix 12 by a contact between its C terminus and the lysine of helix 4 has the same impact in human and mouse constitutive androstane receptor (CAR) GeneRIF 9970

Burk O., Koch I., Raucy J., Hustert E., Eichelbaum M., Brockmoller J., Zanger U.M., Wojnowski L.

J. Biol. Chem. 279:38379-38385(2004) GeneRIF 9970 · Mapped (41)
pregnane X receptor (PXR) and constitutively activated receptor (CAR) mediate induction of CYP3A5 in human liver and intestine GeneRIF 9970

Huang W., Zhang J., Wei P., Schrader W.T., Moore D.D.

Mol. Endocrinol. 18:2402-2408(2004) GeneRIF 9970 · Mapped (25)
The antiemetic meclizine is both an agonist ligand for mouse CAR and an inverse agonist for human CAR. GeneRIF 9970

Assenat E., Gerbal-Chaloin S., Larrey D., Saric J., Fabre J.M., Maurel P., Vilarem M.J., Pascussi J.M.

Hepatology 40:951-960(2004) GeneRIF 9970 · Mapped (24)
negative regulation of CAR a glucocorticoid-responsive gene via proinflammatory cytokine interleukin 1beta (IL-1beta) GeneRIF 9970

Swales K., Kakizaki S., Yamamoto Y., Inoue K., Kobayashi K., Negishi M.

J. Biol. Chem. 280:3458-3466(2005) GeneRIF 9970 · Mapped (26)
The two cis-acting elements the distal PBREM and the proximal OARE within the chromatin structure are both regulated by CAR in response to okadaic acid and TCPOBOP to maximally induce the CYP2B6 promoter. GeneRIF 9970

Jyrkkarinne J., Windshugel B., Makinen J., Ylisirnio M., Perakyla M., Poso A., Sippl W., Honkakoski P.

J. Biol. Chem. 280:5960-5971(2005) GeneRIF 9970 · Mapped (21)
studies identified several amino acids within helices 3 (Asn(165)) 5 (Val(199)) 11 (Tyr(326) Ile(330) and Gln(331)) and 12 (Leu(343) and Ile(346)) that contribute to the high basal activity of human CAR GeneRIF 9970

Huang W., Zhang J., Washington M., Liu J., Parant J.M., Lozano G., Moore D.D.

Mol. Endocrinol. 19:1646-1653(2005) GeneRIF 9970 · Mapped (25)
NR1I3 has a role in regulating both liver homeostasis and tumorigenesis in response to xenobiotic stresses GeneRIF 9970

Chen Y., Kissling G., Negishi M., Goldstein J.A.

J. Pharmacol. Exp. Ther. 314:1125-1133(2005) GeneRIF 9970 · Mapped (43)
there is cross talk between distal CAR/PXR sites and HNF4alpha binding sites in the CYP2C9 promoter and that the HNF4alpha sites are required for maximal induction of the CYP2C9 promoter. GeneRIF 9970

Ferguson S.S., Chen Y., LeCluyse E.L., Negishi M., Goldstein J.A.

Mol. Pharmacol. 68:747-757(2005) GeneRIF 9970 · Mapped (48)
role in transcriptional regulation of CYP2C8 GeneRIF 9970

Chen X., Zhang J., Baker S.M., Chen G.

Toxicology 231:224-233(2007) GeneRIF 9970 · Mapped (23)
hCAR mediates the methotrexate induction of hSULT2A1. GeneRIF 9970

Pascussi J.M., Robert A., Moreau A., Ramos J., Bioulac-Sage P., Navarro F., Blanc P., Assenat E., Maurel P., Vilarem M.J.

Hepatology 45:1146-1153(2007) GeneRIF 9970 · Mapped (28)
observations suggest that HNF4alpha1 positively regulates hCAR expression in normal developing and adult livers whereas HNF4alpha7 represses hCAR gene expression in hepatocellular carcinoma GeneRIF 9970

Wortham M., Czerwinski M., He L., Parkinson A., Wan Y.J.

Drug Metab. Dispos. 35:1700-1710(2007) GeneRIF 9970 · Mapped (28)
interindividual variation in the expression level of CAR probably determines variation in expression and activity of a broad scope of xenobiotic metabolism genes GeneRIF 9970

Patel R.D., Hollingshead B.D., Omiecinski C.J., Perdew G.H.

Hepatology 46:209-218(2007) GeneRIF 9970 · Mapped (26)
Role of aryl hydrocarbon receptor in drug metabolism demonstrates in vivo up-regulation of androstane receptor through chemical exposure. GeneRIF 9970

Hor S.Y., Lee S.C., Wong C.I., Lim Y.W., Lim R.C., Wang L.Z., Fan L., Guo J.Y., Lee H.S., Goh B.C. et al.

Pharmacogenomics J. 8:139-146(2008) GeneRIF 9970 · Mapped (36)
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator); Inter-individual/inter-ethnic variations of docetaxel and doxorubicin pharmacokinetics or pharmacodynamics exist but genotypic variability of CAR cannot account for this variability. GeneRIF 9970