Mukae S., Aoki S., Itoh S., Nishio K., Iwata T., Ueda H., Geshi E., Fuzimaki T., Katagiri T.

Jpn. Circ. J. 63:759-762(1999) GAD 117779 · Mapped (3)
Associated with CARDIOVASCULAR: hypertension; GAD 117779

Kusser B., Braun A., Praun M., Illi S., von Mutius E., Roscher A.A.

Biol. Chem. 382:885-889(2001) GAD 117783 GeneRIF 624 GAD 117780 GAD 117777 · Mapped (6)
Associated with IMMUNE: Asthma; GAD 117780 GAD 117777 Not Associated with IMMUNE: asthma; GAD 117783 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Maltais I., Bachvarova M., Maheux P., Perron P., Marceau F., Bachvarov D.

Can. J. Physiol. Pharmacol. 80:323-327(2002) GAD 117778 GeneRIF 624 · Mapped (5)
Associated with RENAL: altered urinary albumin/creatinine values; GAD 117778 Observational study of gene-disease association. (HuGE Navigator); Bradykinin B2 receptor exon 1 polymorphism may represent a susceptibility marker for nephropathy progression in diabetic patients. GeneRIF 624

Freiberger T., Vyskocilova M., Kolarova L., Kuklinek P., Krystufkova O., Lahodna M., Hanzlikova J., Litzman J.

Hum. Immunol. 63:492-494(2002) GAD 117784 GeneRIF 624 · Mapped (3)
Not Associated with CARDIOVASCULAR: angioedema; GAD 117784 Observational study of gene-disease association. (HuGE Navigator); Exon 1 polymorphism of the B2BKR gene does not influence the clinical status of patients with hereditary angioedema. GeneRIF 624

Hallberg P., Lind L., Michaelsson K., Karlsson J., Kurland L., Kahan T., Malmqvist K., Ohman K.P., Nystrom F., Melhus H.

J. Hypertens. 21:621-624(2003) GAD 117785 GeneRIF 624 · Mapped (3)
Associated with CARDIOVASCULAR: left ventricular hypertrophy; GAD 117785 Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 624

Fischer M., Lieb W., Marold D., Berthold M., Baessler A., Lowel H., Hense H.W., Hengstenberg C., Holmer S., Schunkert H. et al.

Clin. Sci. 107:505-511(2004) GAD 117788 GeneRIF 624 · Mapped (3)
Not Associated with CARDIOVASCULAR: myocardial infarct; GAD 117788 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Cui J., Melista E., Chazaro I., Zhang Y., Zhou X., Manolis A.J., Baldwin C.T., Destefano A.L., Gavras H.

J. Hypertens. 23:55-62(2005) GAD 117800 GeneRIF 624 · Mapped (6)
Associated with CARDIOVASCULAR: hypertension; GAD 117800 the two bradykinin receptors may play a role in blood pressure regulation; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Fu Y., Katsuya T., Matsuo A., Yamamoto K., Akasaka H., Takami Y., Iwashima Y., Sugimoto K., Ishikawa K., Ohishi M. et al.

Hypertens. Res. 27:933-938(2004) GAD 117790 GeneRIF 624 · Mapped (3)
Not Associated with CARDIOVASCULAR: hypertension; left ventricular hypertrophy; GAD 117790 polymorphism (-58 T/C) in the promoter region of BDKRB might be a risk factor and might have a synergetic effect with the ACE for LVH in hypertensives but it is not associated with hypertension in the Japanese population; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Aoki S., Mukae S., Itoh S., Sato R., Nishio K., Ueda H., Iwata T., Katagiri T.

Jpn Heart J 42:15-28(2001) GeneRIF 624 · Mapped (9)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Wang B., Dang A., Liu G.

Hypertens. Res. 24:299-302(2001) GeneRIF 624 GAD 117791 · Mapped (3)
Associated with CARDIOVASCULAR: hypertension; GAD 117791 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Aoki S., Mukae S., Itoh S., Sato R., Nishio K., Iwata T., Katagiri T.

Jpn. Circ. J. 65:621-626(2001) GeneRIF 624 · Mapped (4)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Lee Y.J., Tsai J.C.

Metab. Clin. Exp. 50:1346-1350(2001) GeneRIF 624 · Mapped (14)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Sawant S., Snyman C., Bhoola K.

Int. Immunopharmacol. 1:2063-2080(2001) GeneRIF 624 · Mapped (5)
B1 and B2 receptor expression was enhanced in tumor cells and tissue adjacent to gastric cancer compared with gastric ulcers. GeneRIF 624

Pizard A., Blaukat A., Michineau S., Dikic I., Muller-Esterl W., Alhenc-Gelas F., Rajerison R.M.

Biochemistry 40:15743-15751(2001) GeneRIF 624 · Mapped (3)
Two cysteine residues located in the carboxyterminal domain of the bradykinin B2 receptor are palmitoylated and play a critical role in the response of the receptor to ligand binding. GeneRIF 624

Duchene J., Schanstra J., Cellier E., Bascands J.L., Girolami J.P.

Nephrologie 23:39-41(2002) GeneRIF 624 · Mapped (3)
Bradykinin can also induce antimitogenic effects using an alternative signal transduction pathway for the B2 receptor. GeneRIF 624

Valdes G., Germain A.M., Corthorn J., Chacon C., Figueroa C.D., Muller-Esterl W.

Endocrine 16:207-215(2001) GeneRIF 624 · Mapped (3)
presence of B2R was studied in uteri obtained in luteal phase and in idiopathic pregnancy loss as well as in preterm and term pregnancies GeneRIF 624

Newton R., Eddleston J., Haddad e.l.-B., Hawisa S., Mak J., Lim S., Fox A.J., Donnelly L.E., Chung K.F.

Eur. J. Pharmacol. 441:193-202(2002) GeneRIF 624 · Mapped (5)
Bradykinin B2 receptors are upregulated by inflammatory stimuli in bronchial epithelial cells. GeneRIF 624

Mulatero P., Williams T.A., Milan A., Paglieri C., Rabbia F., Fallo F., Veglio F.

J. Clin. Endocrinol. Metab. 87:3337-3343(2002) GeneRIF 624 GAD 117795 · Mapped (15)
Associated with CARDIOVASCULAR: blood pressure; GAD 117795 Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor polymorphism; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Kang D.S., Leeb-Lundberg L.M.

Mol. Pharmacol. 62:281-288(2002) GeneRIF 624 · Mapped (8)
the C-terminal domain participates intimately in the efficacy of B1R and B2R G(q/11) coupling by contributing both positive and negative regulatory epitopes. GeneRIF 624

Lamb M.E., Zhang C., Shea T., Kyle D.J., Leeb-Lundberg L.M.

Biochemistry 41:14340-14347(2002) GeneRIF 624 · Mapped (5)
B2R is constitutively targeted to caveolae-related lipid rafts in HEK293 cells and appears to shuttle the agonist through these domains whereas B1R may be there by default. GeneRIF 624

Zychma M.J., Gumprecht J., Trautsolt W., Szydlowska I., Grzeszczak W.

Am. J. Nephrol. 23:112-116(2003) GeneRIF 624 GAD 117782 GAD 117798 · Mapped (5)
Not Associated with METABOLIC: diabetes, type 2; GAD 117782 Not Associated with METABOLIC: diabetes, type 2; nephropathy in other diseases; GAD 117798 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 624

Jong Y.J., Dalemar L.R., Seehra K., Baenziger N.L.

Int. Immunopharmacol. 2:1833-1840(2002) GeneRIF 624 · Mapped (3)
elevated level of BK found in tissue injury is one of the major risk factors for development of Alzheimer's disease GeneRIF 624

Mukae S., Itoh S., Aoki S., Iwata T., Nishio K., Sato R., Katagiri T.

J Hum Hypertens 16:857-863(2002) GeneRIF 624 GAD 117803 · Mapped (20)
Associated with OTHER: cough; GAD 117803 Observational study of gene-disease association. (HuGE Navigator); Susceptibility to develop cough is associated with a genetic variant of the bradykinin B2 receptor promoter. GeneRIF 624

Weiss J., Hesse C., Haefeli W.E.

Clin. Chem. Lab. Med. 41:281-283(2003) GeneRIF 624 · Mapped (3)
Observational study of genetic testing. (HuGE Navigator) GeneRIF 624

Trevisani M., Amadesi S., Schmidlin F., Poblete M.T., Bardella E., Maggiore B., Harrison S., Figueroa C.D., Tognetto M., Navarra G. et al.

Gastroenterology 125:126-135(2003) GeneRIF 624 · Mapped (9)
Bradykinin is a powerful spasmogen via B(2) receptor activation in the normal and especially in the inflamed human gallbladder. GeneRIF 624