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16 results for uniprot:Q61120Drop in citationmapping

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A variety of functions of conventional and neuronal Shc adapter molecules in phosphotyrosine-mediated signalings.

Nakamura T., Mori N.

Seikagaku 73:1322-1325(2001) GeneRIF 20418 · Mapped (4)
role in phosphotyrosine-mediated signalings and neuronal plasticities GeneRIF 20418

ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.

Liu H.Y., Meakin S.O.

J. Biol. Chem. 277:26046-26056(2002) GeneRIF 20418 · UniProtKB (3) · Mapped (8)
binds the Trk receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain GeneRIF 20418

The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia.

Troglio F., Echart C., Gobbi A., Pawson T., Pelicci P.G., De Simoni M.G., Pelicci G.

Proc. Natl. Acad. Sci. U.S.A. 101:15476-15481(2004) GeneRIF 20418 MGI 106179 · Mapped (3)
Rai has a functional neuroprotective role in brain injury with possible implications in the treatment of stroke GeneRIF 20418

Domain-specific function of ShcC docking protein in neuroblastoma cells.

Miyake I., Hakomori Y., Misu Y., Nakadate H., Matsuura N., Sakamoto M., Sakai R.

Oncogene 24:3206-3215(2005) GeneRIF 20418 · Mapped (5)
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma cells GeneRIF 20418

Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation.

Savino M.T., Ortensi B., Ferro M., Ulivieri C., Fanigliulo D., Paccagnini E., Lazzi S., Osti D., Pelicci G., Baldari C.T.

J. Immunol. 182:301-308(2009) GeneRIF 20418 MGI 106179 · Mapped (3)
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity. GeneRIF 20418

Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.

Colley B.S., Cavallin M.A., Biju K., Marks D.R., Fadool D.A.

BMC Neurosci 10:8-8(2009) GeneRIF 20418 · Mapped (4)
study reports co-localization of adaptor proteins nShc & Grb10 with Kv1.3 channel in the olfactory bulb neural lamina; BDNF-induced current suppression of the Kv1.3 channel was prevented by both nShc and Grb10 GeneRIF 20418

Evolution of Shc functions from nematode to human.

Luzi L., Confalonieri S., Di Fiore P.P., Pelicci P.G.

Curr. Opin. Genet. Dev. 10:668-674(2000) MGI 106179 · Mapped (8)

The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.

Sakai R., Henderson J.T., O'Bryan J.P., Elia A.J., Saxton T.M., Pawson T.

Neuron 28:819-833(2000) MGI 106179 · Mapped (19)

Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135.

Kojima T., Yoshikawa Y., Takada S., Sato M., Nakamura T., Takahashi N., Copeland N.G., Gilbert D.J., Jenkins N.A., Mori N.

Biochem. Biophys. Res. Commun. 284:1039-1047(2001) MGI 106179 · Mapped (30)

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

Tarr P.E., Roncarati R., Pelicci G., Pelicci P.G., D'Adamio L.

J. Biol. Chem. 277:16798-16804(2002) MGI 106179 GeneRIF 20418 · UniProtKB (1) · Mapped (34)
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. GeneRIF 20418

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.

Zambrowicz B.P., Abuin A., Ramirez-Solis R., Richter L.J., Piggott J., BeltrandelRio H., Buxton E.C., Edwards J., Finch R.A., Friddle C.J. et al.

Proc. Natl. Acad. Sci. U.S.A. 100:14109-14114(2003) MGI 106179 · Mapped (23,055)

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription.

Ishii S., Iizuka K., Miller B.C., Uyeda K.

Proc. Natl. Acad. Sci. U.S.A. 101:15597-15602(2004) MGI 106179 · Mapped (5)

Genetic analysis of the hypothalamic corticotropin-releasing factor system.

Garlow S.J., Boone E., Li W., Owens M.J., Nemeroff C.B.

Endocrinology 146:2362-2368(2005) MGI 106179 · Mapped (17)

Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor.

Miyamoto Y., Chen L., Sato M., Sokabe M., Nabeshima T., Pawson T., Sakai R., Mori N.

J. Neurosci. 25:1826-1835(2005) MGI 106179 GeneRIF 20418 · Mapped (18)
ShcC mediates TrkB-Ras/MAPK signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory. GeneRIF 20418

Lack of changes in the PI3K/AKT survival pathway in the spinal cord motor neurons of a mouse model of familial amyotrophic lateral sclerosis.

Peviani M., Cheroni C., Troglio F., Quarto M., Pelicci G., Bendotti C.

Mol. Cell. Neurosci. 34:592-602(2007) MGI 106179 · Mapped (3)

A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.

Pelicci G., Dente L., De Giuseppe A., Verducci-Galletti B., Giuli S., Mele S., Vetriani C., Giorgio M., Pandolfi P.P., Cesareni G. et al.

Oncogene 13:633-641(1996) MGI 106179 · UniProtKB (2) · Mapped (4)

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