Sica G.L., Choi I.-H., Zhu G., Tamada K., Wang S.-D., Tamura H., Chapoval A.I., Flies D.B., Bajorath J., Chen L.

Immunity 18:849-861(2003) GeneRIF 79679 · UniProtKB (2) · Mapped (2)
May participate in negative regulation of cell-mediated immunity in peripheral tissues GeneRIF 79679

Prasad D.V.R., Richards S., Mai X.M., Dong C.

Immunity 18:863-873(2003) GeneRIF 79679 · UniProtKB (1) · Mapped (3)
Negative regulator of T cell activation. (B7S1) GeneRIF 79679

Choi I.-H., Zhu G., Sica G.L., Strome S.E., Cheville J.C., Lau J.S., Zhu Y., Flies D.B., Tamada K., Chen L.

J. Immunol. 171:4650-4654(2003) GeneRIF 79679 · UniProtKB (1) · Mapped (3)
Tight regulation of B7-H4 expression at the translational level is observed in normal peripheral tissues and a potential role indicated in the evasion of tumor immunity. GeneRIF 79679

Salceda S., Tang T., Kmet M., Munteanu A., Ghosh M., Macina R., Liu W., Pilkington G., Papkoff J.

Exp. Cell Res. 306:128-141(2005) GeneRIF 79679 · UniProtKB (1) · Mapped (2)
B7-H4 mRNA and protein are overexpressed in human serous ovarian cancers and breast cancers. GeneRIF 79679

Kryczek I., Zou L., Rodriguez P., Zhu G., Wei S., Mottram P., Brumlik M., Cheng P., Curiel T., Myers L. et al.

J. Exp. Med. 203:871-881(2006) GeneRIF 79679 · UniProtKB (1) · Mapped (2)
B7-H4+ tumor macrophages constitute a novel suppressor cell population in ovarian cancer; B7-H4 expression represents a critical checkpoint in determining host responses to dysfunctional cytokines in ovarian cancer. GeneRIF 79679

Kryczek I., Wei S., Zou L., Zhu G., Mottram P., Xu H., Chen L., Zou W.

J. Immunol. 177:40-44(2006) GeneRIF 79679 · UniProtKB (1) · Mapped (12)
B7-H4 in human antigen-presenting cells negatively regulates T cell responses. GeneRIF 79679

Krambeck A.E., Thompson R.H., Dong H., Lohse C.M., Park E.S., Kuntz S.M., Leibovich B.C., Blute M.L., Cheville J.C., Kwon E.D.

Proc. Natl. Acad. Sci. U.S.A. 103:10391-10396(2006) GeneRIF 79679 · UniProtKB (1) · Mapped (2)
patients with renal cell carcinoma (RCC) tumors expressing both B7-H4 and B7-H1 are at an even greater risk of death from RCC GeneRIF 79679

Chen Y., Yang C., Xie Z., Zou L., Ruan Z., Zhang X., Tang Y., Fei L., Jia Z., Wu Y.

Kidney Int. 70:2092-2099(2006) GeneRIF 79679 · Mapped (4)
T-cell and epithelial cell crosstalk-associated B7-H4 induces T-cell activation and is a potential activator that promotes tubular lesion GeneRIF 79679

Simon I., Katsaros D., Rigault de la Longrais I., Massobrio M., Scorilas A., Kim N.W., Sarno M.J., Wolfert R.L., Diamandis E.P.

Gynecol. Oncol. 106:334-341(2007) GeneRIF 79679 · Mapped (3)
B7-H4 expression was low in normal ovaries and in benign tumors while half of early stage and two-thirds of late stage cancers over-expressed B7-H4. GeneRIF 79679

Miyatake T., Tringler B., Liu W., Liu S.-H., Papkoff J., Enomoto T., Torkko K.C., Dehn D.L., Swisher A., Shroyer K.R.

Gynecol. Oncol. 106:119-127(2007) GeneRIF 79679 · UniProtKB (1) · Mapped (2)
B7-H4 is overexpressed in hyperplastic and malignant endometrial epithelium and is correlated with the T cell number associated with the tumor. B7-H4 overexpression may reflect a aggressive biologic potential and play a role in tumor immune surveillance. GeneRIF 79679

Awadallah N.S., Shroyer K.R., Langer D.A., Torkko K.C., Chen Y.K., Bentz J.S., Papkoff J., Liu W., Nash S.R., Shah R.J.

Pancreas 36:200-206(2008) GeneRIF 79679 · Mapped (34)
B7-H4 was expressed more often in pancreatic ductal carcinoma than was p53. GeneRIF 79679

Thompson R.H., Zang X., Lohse C.M., Leibovich B.C., Slovin S.F., Reuter V.E., Cheville J.C., Blute M.L., Russo P., Kwon E.D. et al.

Cancer Res. 68:6054-6058(2008) GeneRIF 79679 · Mapped (3)
renal cell carcinoma patients are more likely to have detectable sB7x compared with controls and higher sB7x levels correlate with advanced tumor stage GeneRIF 79679

Hinks A., Barton A., Shephard N., Eyre S., Bowes J., Cargill M., Wang E., Ke X., Kennedy G.C., John S. et al.

Arthritis Rheum. 60:258-263(2009) GeneRIF 79679 · Mapped (3)
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) GeneRIF 79679