Hall R.J., Merriman M.E., Green R.A., Markham V.H., Smyth D.J., Heward J.M., Jennings C.E., Braithwaite A.W., Cundy T., Darlow B.A. et al.

Eur. J. Hum. Genet. 11:840-844(2003) GAD 121257 GeneRIF 1630 · Mapped (4)
Not Associated with IMMUNE: rheumatoid arthritis; diabetes, type 1; Graves' disease; Control:2,225 control subjects;Case:2,253 subjects with rheumatoid arthritis, type I diabetes and Graves' disease New Zealand and UK GAD 121257 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 1630

de Jong M.M., te Meerman G.J., van der Graaf W.T., de Vries E.G., Nolte I.M., Mulder M.J., Bruinenberg M., van der Steege G., Schaapveld M., Sijmons R.H. et al.

Dig Liver Dis 36:821-823(2004) GAD 121258 GeneRIF 1630 · Mapped (4)
Not Associated with CANCER: colorectal cancer; Control:220:controls;Case:625 unselected Caucasian colorectal cancer patients GAD 121258 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 1630

Graziano F., Cascinu S., Staccioli M.P., Catalano V., Rossi M.C., Baldelli A.M., Giordani P., Muretto P., Catalano G.

BMC Cancer 1:9-9(2001) GeneRIF 1630 · Mapped (35)
Altered expression of DCC protein is detectable in gastric carcinomas an event that may have a role in the development of the disease. GeneRIF 1630

Shekarabi M., Kennedy T.E.

Mol. Cell. Neurosci. 19:1-17(2002) GeneRIF 1630 · Mapped (4)
The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. GeneRIF 1630

Inokuchi K., Yamaguchi H., Hanawa H., Tanosaki S., Nakamura K., Tarusawa M., Miyake K., Shimada T., Dan K.

Clin. Cancer Res. 8:1882-1888(2002) GeneRIF 1630 · Mapped (4)
Loss of dcc gene expression is associated with acute myelogenous leukemia GeneRIF 1630

Traicoff J.L., Willson J.K., Markowitz S.D.

J. Biomed. Sci. 9:716-720(2002) GeneRIF 1630 · Mapped (4)
loss of DCC expression occurs in some colon adenomas but is insufficient to drive the adenoma to carcinoma progression. GeneRIF 1630

Zhang H., Arbman G., Sun X.F.

Cancer Detect. Prev. 27:216-221(2003) GeneRIF 1630 · Mapped (4)
data suggest that the codon 201 polymorphism of the DCC gene was a target of LOH and predicted prognosis in colorectal cancer patients GeneRIF 1630

Geisbrecht B.V., Dowd K.A., Barfield R.W., Longo P.A., Leahy D.J.

J. Biol. Chem. 278:32561-32568(2003) GeneRIF 1630 · Mapped (5)
DCC binds to netrin which regulates its interactions with heparin GeneRIF 1630

Bamias A.T., Bai M.C., Agnantis N.J., Michael M.C., Alamanos Y.P., Stefanaki S.V., Razi E.D., Skarlos D.V., Kappas A.M., Pavlidis N.A.

Cancer Invest. 21:333-340(2003) GeneRIF 1630 · Mapped (4)
Prognostic significance of the DCC gene protein expression in high-risk resected gastric carcinoma GeneRIF 1630

O'Boyle K.

Cancer Invest. 21:484-485(2003) GeneRIF 1630 · Mapped (4)
Deletions in this gene are found in colorectal and gastric cancers GeneRIF 1630

Ramburan A., Chetty R., Hadley G.P., Naidoo R., Govender D.

Mod. Pathol. 17:89-95(2004) GeneRIF 1630 · Mapped (4)
Multiple aberrations involving the DCC locus may play a role in the progression of nephroblastomas and hence confer a poorer prognosis. GeneRIF 1630

Kato H.D., Kondoh H., Inoue T., Asanoma K., Matsuda T., Arima T., Kato K., Yoshikawa T., Wake N.

Gynecol. Oncol. 95:281-289(2004) GeneRIF 1630 · Mapped (5)
DCC/netrin-1 signaling may commit cells to the transition of endometrial gland architecture or function from a proliferating to a secretory phase. GeneRIF 1630

Starinsky S., Figer A., Ben-Asher E., Geva R., Flex D., Fidder H.H., Zidan J., Lancet D., Friedman E.

Int. J. Cancer 114:58-73(2005) GeneRIF 1630 · Mapped (126)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 1630

Arakawa H.

Nat. Rev. Cancer 4:978-987(2004) GeneRIF 1630 · Mapped (9)
Binding of netrin-1 to its receptors inhibits tumour suppressor p53-dependent apoptosis (review) GeneRIF 1630

Kruger R.P., Lee J., Li W., Guan K.L.

J. Neurosci. 24:10826-10834(2004) GeneRIF 1630 · Mapped (9)
DCC binds netrin through the fourth fibronectin type III domain. GeneRIF 1630

Wu J.T., Kakar S., Nelson R.L., Mihalov M.L., Hayward B., Gilbert P.B., Ghosh L.

Appl. Immunohistochem. Mol. Morphol. 13:45-54(2005) GeneRIF 1630 · Mapped (12)
DCC expression appears not to be predictive in poor survival outcome in patients with stage II or III colorectal cancer. GeneRIF 1630

Herincs Z., Corset V., Cahuzac N., Furne C., Castellani V., Hueber A.O., Mehlen P.

J. Cell. Sci. 118:1687-1692(2005) GeneRIF 1630 · Mapped (5)
DCC in both commissural neurons and immortalized cells is partially associated with cholesterol- and sphingolipid-enriched membrane domains named lipid rafts. GeneRIF 1630

Wettergren Y., Odin E., Nilsson S., Willen R., Carlsson G., Gustavsson B.

Cancer Detect. Prev. 29:348-355(2005) GeneRIF 1630 · Mapped (23)
The present study points to a potential influence of folates in regulating DCC expression at multiple levels involving post-transcriptional pathways. GeneRIF 1630

Furne C., Corset V., Herincs Z., Cahuzac N., Hueber A.O., Mehlen P.

Proc. Natl. Acad. Sci. U.S.A. 103:4128-4133(2006) GeneRIF 1630 · Mapped (4)
the localization of DCC to lipid rafts is a prerequisite for its proapoptotic activity both in immortalized cells and in primary neurons GeneRIF 1630

Mosher M.J., Martin L.J., Cupples L.A., Yang Q., Dyer T.D., Williams J.T., North K.E.

Hum. Biol. 77:773-793(2005) GeneRIF 1630 · Mapped (4)
Finds a linkage between the chromosome 18 near marker D18S851 at the third time point and the levels of HDL cholesterol in human males. GeneRIF 1630

Martin M., Simon-Assmann P., Kedinger M., Martin M., Mangeat P., Real F.X., Fabre M.

Eur. J. Cell Biol. 85:769-783(2006) GeneRIF 1630 · Mapped (4)
Results suggest that DCC could regulate cell adhesion and migration through its association with ERM-M (ezrin/radixin/moesin and merlin) proteins. GeneRIF 1630

Bamias A., Yu Z., Weinberger P.M., Markakis S., Kowalski D., Camp R.L., Rimm D.L., Dimopoulos M.A., Psyrri A.

Ann. Oncol. 17:1797-1802(2006) GeneRIF 1630 · Mapped (4)
Patients with low nuclear DCC expression had a 3-year progression-free survival (PFS) rate of 0% compared with 33% of those with high DCC expression (P = 0.0067). GeneRIF 1630

Carvalho A.L., Chuang A., Jiang W.W., Lee J., Begum S., Poeta L., Zhao M., Jeronimo C., Henrique R., Nayak C.S. et al.

Cancer Res. 66:9401-9407(2006) GeneRIF 1630 · Mapped (4)
DCC is a putative conditional tumor-suppressor gene that is epigenetically inactivated by promoter hypermethylation in a majority of head-and-neck squamous cell carcinomas. GeneRIF 1630

Margiotti K., Wafa L.A., Cheng H., Novelli G., Nelson C.C., Rennie P.S.

Mol. Cancer 6:38-38(2007) GeneRIF 1630 · Mapped (4)
Overexpression of the DDC gene in the LNCaP prostate cancer cell line leads to differential expression of a total of 35 genes. GeneRIF 1630

Shiffman D., O'Meara E.S., Bare L.A., Rowland C.M., Louie J.Z., Arellano A.R., Lumley T., Rice K., Iakoubova O., Luke M.M. et al.

Arterioscler. Thromb. Vasc. Biol. 28:173-179(2008) GeneRIF 1630 · Mapped (222)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 1630