Uversky V.N., Li J., Souillac P., Millett I.S., Doniach S., Jakes R., Goedert M., Fink A.L.

J. Biol. Chem. 277:11970-11978(2002) GeneRIF 6620 · Mapped (14)
Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins GeneRIF 6620

Fung K.M., Rorke L.B., Giasson B., Lee V.M., Trojanowski J.Q.

Acta Neuropathol. 106:167-175(2003) GeneRIF 6620 · Mapped (14)
Of medulloblastomas 76% have immunoreactivity for either alpha- or beta-synuclein or both; no immunoreactivity for gamma-synuclein is seen in medulloblastomas. GeneRIF 6620

da Costa C.A., Masliah E., Checler F.

J. Biol. Chem. 278:37330-37335(2003) GeneRIF 6620 · Mapped (11)
Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. GeneRIF 6620

Ohtake H., Limprasert P., Fan Y., Onodera O., Kakita A., Takahashi H., Bonner L.T., Tsuang D.W., Murray I.V., Lee V.M. et al.

Neurology 63:805-811(2004) GeneRIF 6620 · Mapped (12)
2 new AA changes were found in unrelated Lewy body dementia index cases: V70M & P123H at conserved residues in highly conserved regions of the beta-synuclein protein. Mutations in the beta-synuclein gene may predispose to DLB. GeneRIF 6620

Snyder H., Mensah K., Hsu C., Hashimoto M., Surgucheva I.G., Festoff B., Surguchov A., Masliah E., Matouschek A., Wolozin B.

J. Biol. Chem. 280:7562-7569(2005) GeneRIF 6620 · Mapped (14)
the alpha- and gamma-synucleins regulate proteasomal function and beta-synuclein acts as a negative regulator of alpha-synuclein GeneRIF 6620

Sung Y.H., Eliezer D.

Protein Sci. 15:1162-1174(2006) GeneRIF 6620 · Mapped (7)
An 11-residue deletion in the lipid-binding domain of beta-synuclein leads to the destabilization of an entire segment of the micelle-bound helical structure containing the deletion site. GeneRIF 6620

Fan Y., Limprasert P., Murray I.V., Smith A.C., Lee V.M., Trojanowski J.Q., Sopher B.L., La Spada A.R.

Hum. Mol. Genet. 15:3002-3011(2006) GeneRIF 6620 · Mapped (11)
findings indicate that increased expression of beta-synuclein protein results in a reduction of alpha-synuclein protein expression GeneRIF 6620

Brighina L., Okubadejo N.U., Schneider N.K., Lesnick T.G., de Andrade M., Cunningham J.M., Farrer M.J., Lincoln S.J., Rocca W.A., Maraganore D.M.

Neurosci. Lett. 420:229-234(2007) GeneRIF 6620 · Mapped (5)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6620

Suzuki K., Iseki E., Togo T., Yamaguchi A., Katsuse O., Katsuyama K., Kanzaki S., Shiozaki K., Kawanishi C., Yamashita S. et al.

Acta Neuropathol. 114:481-489(2007) GeneRIF 6620 · Mapped (11)
The accumulation of beta-synuclein was detectable only in the pons of Sandhoff disease cases. This differential accumulation of alpha- and beta-synucleins in human lipidoses may be related to functional differences between these two proteins. GeneRIF 6620

Sung Y.H., Eliezer D.

J. Mol. Biol. 372:689-707(2007) GeneRIF 6620 · Mapped (14)
A comparison of the structural and dynamic properties of the free states of all three synucleins is reported in order to shed light on differences that may help to explain their different propensities to aggregate. GeneRIF 6620

Salem S.A., Allsop D., Mann D.M., Tokuda T., El-Agnaf O.M.

Brain Res. 1170:103-111(2007) GeneRIF 6620 · Mapped (11)
Our data confirm the fatty acid binding properties of alpha-syn and to a lesser extent beta-syn but suggest that gamma-syn does not share this same characteristic. GeneRIF 6620

Lee J., Hwang H., Kim T.D.

Protein Pept. Lett. 14:1021-1026(2007) GeneRIF 6620 · Mapped (4)
structural and functional properties of beta-synuclein were characterized using biochemical and bio-physical methods including: a functional assay mass spectrometry size exclusion chromatography circular dichroism (CD) and fluorescence spectroscopy GeneRIF 6620

Rivers R.C., Kumita J.R., Tartaglia G.G., Dedmon M.M., Pawar A., Vendruscolo M., Dobson C.M., Christodoulou J.

Protein Sci. 17:887-898(2008) GeneRIF 6620 · Mapped (11)
The aggregation behavior of alpha- and beta-synuclein as well as a series of chimeric variants were compared by exploring the structural transitions that occur in the presence of a widely used lipid mimetic sodium dodecyl sulfate (SDS). GeneRIF 6620

Ye Q., Wang T.F., Peng Y.F., Xie J., Feng B., Qiu M.Y., Li L.H., Lu A.G., Liu B.Y., Zheng M.H.

Oncol. Rep. 23:429-436(2010) GeneRIF 6620 · Mapped (14)
Gamma-synuclein protein is valuable for evaluation of progression of colorectal carcinoma; it is more sensitive to predict advanced stage and lymph node invasion when combined with either alpha- or beta-synuclein protein. GeneRIF 6620

Varkey J., Isas J.M., Mizuno N., Jensen M.B., Bhatia V.K., Jao C.C., Petrlova J., Voss J.C., Stamou D.G., Steven A.C. et al.

J. Biol. Chem. 285:32486-32493(2010) GeneRIF 6620 · Mapped (8)
Data show that alpha-synuclein beta-synuclein and apolipoprotein A-1 have the conserved functional ability to induce membrane curvature and to convert large vesicles into highly curved membrane tubules and vesicles. GeneRIF 6620

Nishioka K., Wider C., Vilarino-Guell C., Soto-Ortolaza A.I., Lincoln S.J., Kachergus J.M., Jasinska-Myga B., Ross O.A., Rajput A., Robinson C.A. et al.

Arch. Neurol. 67:970-975(2010) GeneRIF 6620 · Mapped (20)
members of the synuclein gene family particularly SNCA and SNCG affect the risk of developing diffuse lewy body disease. GeneRIF 6620

Zibaee S., Fraser G., Jakes R., Owen D., Serpell L.C., Crowther R.A., Goedert M.

J. Biol. Chem. 285:38555-38567(2010) GeneRIF 6620 · Mapped (4)
Human beta-synuclein rendered fibrillogenic by designed mutations. GeneRIF 6620

Noori-Daloii M.R., Kheirollahi M., Mahbod P., Mohammadi F., Astaneh A.N., Zarindast M.R., Azimi C., Mohammadi M.R.

Genet Test Mol Biomarkers 14:725-729(2010) GeneRIF 6620 · Mapped (11)
beta-Synuclein mRNA expression in the control group was significantly higher than that in the schizophrenic group. GeneRIF 6620

Beyer K., Domingo-Sabat M., Santos C., Tolosa E., Ferrer I., Ariza A.

Brain 133:3724-3733(2010) GeneRIF 6620 · Mapped (4)
A drastic diminution of beta-synuclein expression was observed in cortical areas of all samples that presented neuropathological features corresponding to pure diffuse Lewy body pathology GeneRIF 6620

Shaltiel-Karyo R., Frenkel-Pinter M., Egoz-Matia N., Frydman-Marom A., Shalev D.E., Segal D., Gazit E.

PLoS ONE 5:e13863-e13863(2010) GeneRIF 6620 · Mapped (11)
Studies identified molecular interaction domains within the beta-synuclein polypeptide that specifically binds alpha-synuclein. GeneRIF 6620

Davies P., Wang X., Sarell C.J., Drewett A., Marken F., Viles J.H., Brown D.R.

Biochemistry 50:37-47(2011) GeneRIF 6620 · Mapped (14)
Thermodynamic studies in conjunction with EPR confirm that alpha-synuclein beta-synuclein and gamma-synuclein bind copper(II) in a high affinity 1:1 stoichiometry. GeneRIF 6620

Anwar S., Peters O., Millership S., Ninkina N., Doig N., Connor-Robson N., Threlfell S., Kooner G., Deacon R.M., Bannerman D.M. et al.

J. Neurosci. 31:7264-7274(2011) GeneRIF 6620 · Mapped (24)
Synuclein-alpha -beta and -gamma are important in regulating neurotransmitter release from specific populations of midbrain dopamine neurons through mechanisms that differ from those reported in other neurons. GeneRIF 6620

Beyer K., Ispierto L., Latorre P., Tolosa E., Ariza A.

J. Neurol. Sci. 310:112-117(2011) GeneRIF 6620 · Mapped (11)
This study suggested that the pathogenesis of dementia in Parkinson disease indicating that differential sncb expression in the caudate nucleus may represent one of the molecular mechanisms involved in these complex diseases. GeneRIF 6620

Ia K.K., Jeschke G.R., Deng Y., Kamaruddin M.A., Williamson N.A., Scanlon D.B., Culvenor J.G., Hossain M.I., Purcell A.W., Liu S. et al.

Biochemistry 50:6667-6677(2011) GeneRIF 6620 · Mapped (11)
Despite both synucleins sharing considerable sequence homology the level of carboxy-terminal Src kinase-homologous kinase (CHK) phosphorylation of beta-synuclein is significantly higher than that of alpha-synuclein. GeneRIF 6620

Beyer K., Munoz-Marmol A.M., Sanz C., Marginet-Flinch R., Ferrer I., Ariza A.

Neurogenetics 13:61-72(2012) GeneRIF 6620 · Mapped (4)
Data provide evidence for the role of beta-synuclein minor transcript variants in the development of complex diseases and provide new insights into the pathogenesis of Lewy body diseases. GeneRIF 6620