Brown J.K., Jones C.A., Rooney L.A., Caughey G.H., Hall I.P.

Am. J. Physiol. Lung Cell Mol. Physiol. 282:L197-206(2002) GeneRIF 7177 · Mapped (6)
mitogenic effects in human airway smooth muscle cells GeneRIF 7177

Selwood T., Wang Z.M., McCaslin D.R., Schechter N.M.

Biochemistry 41:3329-3340(2002) GeneRIF 7177 · Mapped (6)
stability and catalytic properties mediated by residues at the S1 pocket GeneRIF 7177

Scarpi D., McBride J.D., Leatherbarrow R.J.

J. Pept. Res. 59:90-93(2002) GeneRIF 7177 · Mapped (6)
structure of Bowman-Birk inhibitor derived peptides GeneRIF 7177

Frungieri M.B., Weidinger S., Meineke V., Kohn F.M., Mayerhofer A.

Proc. Natl. Acad. Sci. U.S.A. 99:15072-15077(2002) GeneRIF 7177 · Mapped (28)
Proliferative action is mediated by PAR2 COX2 prostaglandins and PPARgamma : possible relevance to human fibrotic disorders. GeneRIF 7177

Malamud V., Vaaknin A., Abramsky O., Mor M., Burgess L.E., Ben-Yehudah A., Lorberboum-Galski H.

J. Neuroimmunol. 138:115-122(2003) GeneRIF 7177 · Mapped (6)
Beta-tryptase activates peripheral blood mononuclear cells isolated from healthy donors as well as multiple sclerosis (MS) patients inducing release of TNF-alpha IL-6 and IL-1 beta and is most probably an important mediator of inflammation in MS. GeneRIF 7177

Hallgren J., Lindahl S., Pejler G.

J. Mol. Biol. 345:129-139(2005) GeneRIF 7177 · Mapped (9)
Results indicate a key role for heparin in the activation of human betaI- and beta2-tryptase. GeneRIF 7177

Kasacka I., Sawicki B., Roszkowska-Jakimiec W.

Rocz. Akad. Med. Bialymst. 49 Suppl 1:61-63(2004) GeneRIF 7177 · Mapped (10)
Tryptase and chymase and protein levels were determined in mast cells in fibrosarcoma. GeneRIF 7177

Jacob C., Yang P.C., Darmoul D., Amadesi S., Saito T., Cottrell G.S., Coelho A.M., Singh P., Grady E.F., Perdue M. et al.

J. Biol. Chem. 280:31936-31948(2005) GeneRIF 7177 · Mapped (7)
Mast cell tryptase cleaves protease-activated receptor 2 (PAR2) on colonocytes to increase paracellular permeability of the intestine during stress and inflammation. GeneRIF 7177

Pang L., Nie M., Corbett L., Sutcliffe A., Knox A.J.

J. Immunol. 176:3788-3795(2006) GeneRIF 7177 · Mapped (12)
mast cell beta-tryptase selectively cleaves asthmatic airway smooth muscle (ASM)-derived eotaxin and RANTES and abrogates their chemotactic activities thus providing an explanation for the eosinophil paucity in asthmatic ASM bundles GeneRIF 7177

Ashenagar M.S., Sugihara K., Maeda A., Isogai R., Takahashi M., Aisu K., Horiuchi A., Aragane Y., Kawada A., Tezuka T.

Arch. Dermatol. Res. 298:421-426(2007) GeneRIF 7177 · Mapped (9)
Bikunin was found to localize on the cell membrane while tryptase was in the secretary granules of the mast cells from psoriatic lesions. GeneRIF 7177

Nakano S., Mishiro T., Takahara S., Yokoi H., Hamada D., Yukata K., Takata Y., Goto T., Egawa H., Yasuoka S. et al.

Clin. Rheumatol. 26:1284-1292(2007) GeneRIF 7177 · Mapped (7)
Mast cell tryptase secretion into rheumatoid arthritis synovial fluid is higher than Osteoarthritis synovial fluid and stimulates the proliferation of Synovial fibrobalst-like cells. GeneRIF 7177

Akin C., Soto D., Brittain E., Chhabra A., Schwartz L.B., Caughey G.H., Metcalfe D.D.

Clin. Immunol. 123:268-271(2007) GeneRIF 7177 · Mapped (9)
Observational study of gene-disease association. (HuGE Navigator); The disease severity and plasma tryptase levels were not affected by the number of alpha or beta tryptase alleles in mastocytosis patients. GeneRIF 7177

Ribatti D., Nico B., Maxia C., Longo V., Murtas D., Mangieri D., Perra M.T., De Giorgis M., Piras F., Crivellato E. et al.

J. Cell. Mol. Med. 11:585-589(2007) GeneRIF 7177 · Mapped (6)
These results suggest that the characteristic neovascularization observed in pterygium may be sustained at least in part by mast cells angiogenic mediators in particular tryptase. GeneRIF 7177

Schechter N.M., Choi E.J., Selwood T., McCaslin D.R.

Biochemistry 46:9615-9629(2007) GeneRIF 7177 · Mapped (6)
siHTbeta is for the most part an inactive species and any active monomer is a consequence of heparin binding to siHTbeta under dilute conditions where unfavorable thermodynamics and/or kinetics restrict formation of active tetramer. GeneRIF 7177

Mullan C.S., Riley M., Clarke D., Tatler A., Sutcliffe A., Knox A.J., Pang L.

Am. J. Respir. Cell Mol. Biol. 38:600-608(2008) GeneRIF 7177 · Mapped (6)
Up-regulates interleukin-8 expression in airway smooth muscle cells through a protease-activated receptor(PAR)-2-independent proteolytic mechanism. GeneRIF 7177

Tatler A.L., Porte J., Knox A., Jenkins G., Pang L.

Biochem. Biophys. Res. Commun. 370:239-242(2008) GeneRIF 7177 · Mapped (15)
Tryptase activates TGFbeta via a PAR2-independent proteolytic mechanism in human ASM cells and may help understanding the role of tryptase in asthma. GeneRIF 7177

Rastogi P., Young D.M., McHowat J.

Am. J. Physiol. Lung Cell Mol. Physiol. 295:L925-32(2008) GeneRIF 7177 · Mapped (10)
Tryptase stimulation of human small airway epithelial cells increased membrane-associated calcium-independent phospholipase A(2)gamma (iPLA(2)gamma) activity resulting in increased arachidonic acid and PGE(2) release. GeneRIF 7177

Jackson N.E., Wang H.W., Bryant K.J., McNeil H.P., Husain A., Liu K., Tedla N., Thomas P.S., King G.C., Hettiaratchi A. et al.

J. Biol. Chem. 283:34178-34187(2008) GeneRIF 7177 · UniProtKB (1) · Mapped (6)
alternative mRNA splicing in multiple human tryptase genes has a role in regulating tetramer formation GeneRIF 7177

Barczyk M., Mysliwiec M., Kalinowski M., Rowinski M., Brzosko S.

Transplant. Proc. 40:3437-3439(2008) GeneRIF 7177 · Mapped (6)
Positive correlation between serum tryptase concentration and hemoglobin hematocrit red blood cell count and hepatic cell damage in kidney transplantation. GeneRIF 7177

Ribatti D., Nico B., Finato N., Crivellato E., Beltrami C.A.

Cancer Lett. 279:209-212(2009) GeneRIF 7177 · Mapped (8)
MC are immunoreactive to cathepsin-G in human cutaneous mastocytosis as well as the co-localization of tryptase and cathepsin-G in MC secretory granules. GeneRIF 7177

Radhakrishnan Y., Hamil K.G., Tan J.A., Grossman G., Petrusz P., Hall S.H., French F.S.

Biol. Reprod. 81:647-656(2009) GeneRIF 7177 · Mapped (20)
SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity. GeneRIF 7177

Schiemann F., Brandt E., Gross R., Lindner B., Mittelstadt J., Sommerhoff C.P., Schulmistrat J., Petersen F.

J. Immunol. 183:2223-2231(2009) GeneRIF 7177 · Mapped (10)
Proteolytic cleavage of cathelicidin LL-37 by mast cells (MC) is mediated by beta-tryptase the the major LL-37 processing enzyme in MC. GeneRIF 7177

Lee J.W., Park J.H., Park D.I., Park J.H., Kim H.J., Cho Y.K., Sohn C.I., Jeon W.K., Kim B.I.

Dig. Dis. Sci. 55:2922-2928(2010) GeneRIF 7177 · Mapped (7)
Tryptase seems to play an important role in the control of human colonic mucosal permeability and enhanced tryptase activity was responsible for the increased permeability of rectal mucosa in irritable bowel patients GeneRIF 7177

Gao F., Zhao Y., Feng Y.Q., Huo R., Xue W.J., Wang F.G., Lv R.R., Xue F., Li Q., Zhang J.

Zhonghua Zheng Xing Wai Ke Za Zhi 26:132-135(2010) GeneRIF 7177 · Mapped (7)
MCT gene may play a role in the pathogenesis of scar. GeneRIF 7177

Ferrer M., Nunez-Cordoba J.M., Luquin E., Grattan C.E., De la Borbolla J.M., Sanz M.L., Schwartz L.B.

Clin. Exp. Allergy 40:1760-1766(2010) GeneRIF 7177 · Mapped (7)
these data show that patients suffering from active active chronic urticaria (CU) have significantly higher total tryptase levels than asymptomatic CU atopics without CU and healthy subjects. GeneRIF 7177