Kesh S., Mensah N.Y., Peterlongo P., Jaffe D., Hsu K., VAN DEN Brink M., O'reilly R., Pamer E., Satagopan J., Papanicolaou G.A.

Ann. N. Y. Acad. Sci. 1062:95-103(2005) GAD 154372 GeneRIF 7096 · Mapped (19)
Associated with INFECTION: aspergillosis; GAD 154372 Observational study of gene-disease association. (HuGE Navigator); Presence of TLR1 239G > C (Arg80 > Thr) or the presence of both TLR1 743A > G (Asn248 > Ser) and TLR6 745C > T (Ser249 > Pro) single nucleotide polymorphism is associated with invasive aspergillosis following allogeneic stem cell transplantation. GeneRIF 7096

Karoly E., Fekete A., Banki N.F., Szebeni B., Vannay A., Szabo A.J., Tulassay T., Reusz G.S.

Pediatr. Res. 61:371-374(2007) GAD 154375 GeneRIF 7096 · Mapped (16)
Associated with INFECTION: urinary tract infection; GAD 154375 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7096

Misch E.A., Macdonald M., Ranjit C., Sapkota B.R., Wells R.D., Siddiqui M.R., Kaplan G., Hawn T.R.

PLoS Negl Trop Dis 2:e231-e231(2008) GAD 560253 GeneRIF 7096 · Mapped (14)
Associated with INFECTION: leprosy; GAD 560253 Findings suggest that TLR1 deficiency influences adaptive immunity during leprosy infection to affect clinical manifestations such as nerve damage and disability; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7096

Siezen C.L., Bont L., Hodemaekers H.M., Ermers M.J., Doornbos G., Van't Slot R., Wijmenga C., Houwelingen H.C., Kimpen J.L., Kimman T.G. et al.

Pediatr. Infect. Dis. J. 28:333-335(2009) GAD 560245 GeneRIF 7096 · Mapped (965)
Not Associated with INFECTION: respiratory syncytial virus bronchiolitis; GAD 560245 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 7096

Hosgood H.D., Zhang L., Shen M., Berndt S.I., Vermeulen R., Li G., Yin S., Yeager M., Yuenger J., Rothman N. et al.

Occup Environ Med 66:848-853(2009) GAD 560236 GeneRIF 7096 · Mapped (1,047)
Not Associated with PHARMACOGENOMIC: benzene haematotoxicity; GAD 560236 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7096

Spitzer J.H., Visintin A., Mazzoni A., Kennedy M.N., Segal D.M.

Eur. J. Immunol. 32:1182-1187(2002) GeneRIF 7096 · Mapped (12)
The extracellular but not cytoplasmic domain of TLR1 inhibits Toll-like receptor 4 signaling in endothelial cells. TLR1 might restrain the dangerous innate response to LPS by binding to TLR4 and preventing the formation of active signaling complexes. GeneRIF 7096

Alexopoulou L., Thomas V., Schnare M., Lobet Y., Anguita J., Schoen R.T., Medzhitov R., Fikrig E., Flavell R.A.

Nat. Med. 8:878-884(2002) GeneRIF 7096 · Mapped (19)
These data indicate that TLR1 and TLR2 are required for lipoprotein recognition and hat defects in the TLR1/2 signaling pathway may account for human hyporesponsiveness to Borrelia burgdorferi OspA vaccination. GeneRIF 7096

Fenhalls G., Squires G.R., Stevens-Muller L., Bezuidenhout J., Amphlett G., Duncan K., Lukey P.T.

Am. J. Respir. Cell Mol. Biol. 29:28-38(2003) GeneRIF 7096 · Mapped (22)
All nine patients expressed all of the TLRs studied whereas only five out of the nine patients had any granulomas positive for IL-4.The associations between TLRs 1 5 and 9 were different in IL-4-negative compared with IL-4-positive patients. GeneRIF 7096

Sandor F., Latz E., Re F., Mandell L., Repik G., Golenbock D.T., Espevik T., Kurt-Jones E.A., Finberg R.W.

J. Cell Biol. 162:1099-1110(2003) GeneRIF 7096 · Mapped (14)
TLR1 and TLR2 are required for ara-lipoarabinomannan- and tripalmitoyl cysteinyl lipopeptide-stimulated cytokine secretion from mononuclear cells. Confocal microscopy revealed that TLR1 and TLR2 cotranslationally form heterodimeric complexes GeneRIF 7096

Lee J.Y., Zhao L., Youn H.S., Weatherill A.R., Tapping R., Feng L., Lee W.H., Fitzgerald K.A., Hwang D.H.

J. Biol. Chem. 279:16971-16979(2004) GeneRIF 7096 · Mapped (28)
Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1 is activated by saturated fatty acid and inhibited by polyunsaturated fatty acid GeneRIF 7096

Klaffenbach D., Rascher W., Rollinghoff M., Dotsch J., Meissner U., Schnare M.

Am. J. Reprod. Immunol. 53:77-84(2005) GeneRIF 7096 · Mapped (14)
The surface expression of TLR1 by FACS analysis after the stimulation of JAR cells with different TLR ligands. GeneRIF 7096

Razonable R.R., Henault M., Lee L.N., Laethem C., Johnston P.A., Watson H.L., Paya C.V.

Antimicrob. Agents Chemother. 49:1617-1621(2005) GeneRIF 7096 · Mapped (14)
TLR2-TLR1 coactivation serves as the underlying mechanism for the proinflammatory toxicities associated with Amphotericin B GeneRIF 7096

Sun J., Wiklund F., Zheng S.L., Chang B., Balter K., Li L., Johansson J.E., Li G., Adami H.O., Liu W. et al.

J. Natl. Cancer Inst. 97:525-532(2005) GeneRIF 7096 GAD 136288 · Mapped (24)
Associated with CANCER: prostate cancer; GAD 136288 The observed multiple associated SNPs at the TLR6-TLR1-TLR10 gene cluster were dependent and suggest the presence of a founder prostate cancer risk variant on this haplotype background; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7096

Babu S., Blauvelt C.P., Kumaraswami V., Nutman T.B.

J. Immunol. 175:1170-1176(2005) GeneRIF 7096 · Mapped (14)
Diminished expression and function of TLR1 is a likely consequence of chronic filarial antigen stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in lymphatic filariasis GeneRIF 7096

Schroder N.W., Diterich I., Zinke A., Eckert J., Draing C., von Baehr V., Hassler D., Priem S., Hahn K., Michelsen K.S. et al.

J. Immunol. 175:2534-2540(2005) GeneRIF 7096 · Mapped (21)
Observational study of gene-disease association. (HuGE Navigator); Reduced signaling via TLR-2/TLR-1 heterodimers protects from late stage Lyme disease in individuals with heterozygous Arg753Gln polymorphism of Tlr-2 GeneRIF 7096

Shimizu T., Kida Y., Kuwano K.

J. Immunol. 175:4641-4646(2005) GeneRIF 7096 · Mapped (17)
Activation of NF-kappa B in monocytic THP-1 cells by a lipid-associated membrane protein (LAMP) from Mycoplasma pneumoniae is mediated by TLR2. GeneRIF 7096

Pierik M., Joossens S., Van Steen K., Van Schuerbeek N., Vlietinck R., Rutgeerts P., Vermeire S.

Inflamm. Bowel Dis. 12:1-8(2006) GeneRIF 7096 · Mapped (17)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7096

Massari P., Visintin A., Gunawardana J., Halmen K.A., King C.A., Golenbock D.T., Wetzler L.M.

J. Immunol. 176:2373-2380(2006) GeneRIF 7096 · Mapped (15)
Toll-Like Receptor 2 (TLR2) recognizes PorB through direct binding and that PorB-induced cell activation is mediated by a TLR2/TLR1 complex GeneRIF 7096

Sun J., Wiklund F., Hsu F.C., Balter K., Zheng S.L., Johansson J.E., Chang B., Liu W., Li T., Turner A.R. et al.

Cancer Epidemiol. Biomarkers Prev. 15:480-485(2006) GeneRIF 7096 · Mapped (31)
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) GeneRIF 7096

Nakata T., Yasuda M., Fujita M., Kataoka H., Kiura K., Sano H., Shibata K.

Cell. Microbiol. 8:1899-1909(2006) GeneRIF 7096 · Mapped (16)
This study suggests that CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the TLR2/TLR1 complex without binding to the receptor complex. GeneRIF 7096

Triantafilou M., Gamper F.G., Haston R.M., Mouratis M.A., Morath S., Hartung T., Triantafilou K.

J. Biol. Chem. 281:31002-31011(2006) GeneRIF 7096 · Mapped (36)
TLR-2/6 and TLR2/1 heterodimer sorting at the cell surface determines heterotypic associations with CD36 and intracellular targeting GeneRIF 7096

Gautam J.K., Ashish, Comeau L.D., Krueger J.K., Smith M.F. Jr.

J. Biol. Chem. 281:30132-30142(2006) GeneRIF 7096 · Mapped (12)
In vitro functional studies involving TLR1 Gly676Ala and TLR1 Gly676Leu results in reduced NF-kappa B activation of signal-deficient mutants. GeneRIF 7096

Nieters A., Beckmann L., Deeg E., Becker N.

Genes Immun. 7:615-624(2006) GeneRIF 7096 · Mapped (31)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 7096

Mizoguchi E., Orihara K., Hamasaki S., Ishida S., Kataoka T., Ogawa M., Saihara K., Okui H., Fukudome T., Shinsato T. et al.

Coron. Artery Dis. 18:31-38(2007) GeneRIF 7096 · Mapped (14)
These data suggest that Toll-like receptor 2 and 4 expression correlates with the extent and severity of coronary artery disease. GeneRIF 7096

Bogunovic M., Dave S.H., Tilstra J.S., Chang D.T., Harpaz N., Xiong H., Mayer L.F., Plevy S.E.

Am. J. Physiol. Gastrointest. Liver Physiol. 292:G1770-83(2007) GeneRIF 7096 · Mapped (21)
Intestinal enteroendocrine cells express TLRs which may be involved in innate immune responses. GeneRIF 7096