Jones J.B., Kern S.E.

Nucleic Acids Res. 28:2363-2368(2000) GeneRIF 4089 · Mapped (2)
DNA-binding protein GeneRIF 4089

Gu L., Chen J., Cui Q.

Zhonghua Zhong Liu Za Zhi 23:293-295(2001) GeneRIF 4089 · Mapped (2)
Alterations in tumor-suppressor gene DPC4 may play an important role during the tumorigenesis of pancreatic cancer. GeneRIF 4089

Bai R.-Y., Koester C., Ouyang T., Hahn S.A., Hammerschmidt M., Peschel C., Duyster J.

Nat. Cell Biol. 4:181-190(2002) GeneRIF 4089 · UniProtKB (3) · Mapped (5)
A point mutation in Smad4 abolished binding to SMIF. GeneRIF 4089

Gu L., Chen J., Liu T., Li L., Lu Z., Luo Y.

Zhonghua Bing Li Xue Za Zhi 30:439-442(2001) GeneRIF 4089 · Mapped (5)
smad4 may play an important role in the regulation of TGFbeta inducible gene expression and subsequent growth inhibition. GeneRIF 4089

Howe J.R., Shellnut J., Wagner B., Ringold J.C., Sayed M.G., Ahmed A.F., Lynch P.M., Amos C.I., Sistonen P., Aaltonen L.A.

Am. J. Hum. Genet. 70:1357-1362(2002) GeneRIF 4089 · Mapped (4)
Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot. GeneRIF 4089

Lee D.K., Kim B.C., Brady J.N., Jeang K.T., Kim S.J.

J. Biol. Chem. 277:33766-33775(2002) GeneRIF 4089 · Mapped (21)
TLV-1 tax represses Smad-mediated TGF-beta signaling. GeneRIF 4089

Friedl W., Uhlhaas S., Schulmann K., Stolte M., Loff S., Back W., Mangold E., Stern M., Knaebel H.P., Sutter C. et al.

Hum. Genet. 111:108-111(2002) GeneRIF 4089 GAD 135206 · UniProtKB (1) · Mapped (3)
Associated with OTHER: Juvenile polyposis syndrome; polyposis, gastric; GAD 135206 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 4089

Inman G.J., Nicolas F.J., Hill C.S.

Mol. Cell 10:283-294(2002) GeneRIF 4089 · Mapped (12)
Nucleocytoplasmic shuttling of Smads 2 3 and 4 permits sensing of TGF-beta receptor activity. GeneRIF 4089

Watanabe Y., Kinoshita A., Yamada T., Ohta T., Kishino T., Matsumoto N., Ishikawa M., Niikawa N., Yoshiura K.

J. Hum. Genet. 47:478-483(2002) GeneRIF 4089 · UniProtKB (2) · Mapped (31)
Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 4089

Fukuchi M., Masuda N., Miyazaki T., Nakajima M., Osawa H., Kato H., Kuwano H.

Cancer 95:737-743(2002) GeneRIF 4089 · Mapped (11)
In this study the expression of Smad4 protein appeared to be correlated with the depth of invasion of esophageal SCC GeneRIF 4089

Kang H.Y., Huang K.E., Chang S.Y., Ma W.L., Lin W.J., Chang C.

J. Biol. Chem. 277:43749-43756(2002) GeneRIF 4089 · Mapped (19)
interactions between AR Smad3 and Smad4 may result in the differential regulation of the AR transactivation which further strengthens their roles in the prostate cancer progression GeneRIF 4089

Ramachandra M., Atencio I., Rahman A., Vaillancourt M., Zou A., Avanzini J., Wills K., Bookstein R., Shabram P.

Cancer Res. 62:6045-6051(2002) GeneRIF 4089 · Mapped (2)
Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis. GeneRIF 4089

Peng B., Fleming J.B., Breslin T., Grau A.M., Fojioka S., Abbruzzese J.L., Evans D.B., Ayers D., Wathen K., Wu T. et al.

Clin. Cancer Res. 8:3628-3638(2002) GeneRIF 4089 · Mapped (2)
Smad4/DPC4 has a role in TGF-beta-mediated inhibition of cell proliferation in vitro and in vivo GeneRIF 4089

Evans R.A., Tian Y.C., Steadman R., Phillips A.O.

Exp. Cell Res. 282:90-100(2003) GeneRIF 4089 · Mapped (21)
Phenotypic and functional changes associated with TGF-beta1-induced fibroblast terminal differentiation are differentially regulated by Smad2 Smad3 and Smad4. GeneRIF 4089

Hummer B.T., Bartlett C., Henry E., Weissman B.E.

J. Cell. Physiol. 194:289-302(2003) GeneRIF 4089 · Mapped (2)
the re-expression of the Smad4 gene by either method partially restored TGF-beta responsiveness in FaDu cells with respect to both growth inhibition and expression of p21WAF1/CIP1 and p15INK4B GeneRIF 4089

Mamot C., Mild G., Reuter J., Laffer U., Metzger U., Terracciano L., Boulay J.L., Herrmann R., Rochlitz C.

Br. J. Cancer 88:420-423(2003) GeneRIF 4089 · Mapped (2)
Smad4 point mutations are prevalent in pancreatic carcinoma they are infrequent in early stages (I-III) of colorectal cancer. GeneRIF 4089

Wu L., Wu Y., Gathings B., Wan M., Li X., Grizzle W., Liu Z., Lu C., Mao Z., Cao X.

J. Biol. Chem. 278:15192-15200(2003) GeneRIF 4089 · Mapped (60)
Interaction domains of Smad4 and ERalpha are mapped and shown to be essential for transcriptional repression of ERalpha by Smad4. GeneRIF 4089

Fink S.P., Mikkola D., Willson J.K., Markowitz S.

Oncogene 22:1317-1323(2003) GeneRIF 4089 · Mapped (12)
Smad4 is not required for nuclear translocation of Smad2 and Smad3 but is needed for activation of at least certain transcriptional responses. GeneRIF 4089

Chou W.C., Prokova V., Shiraishi K., Valcourt U., Moustakas A., Hadzopoulou-Cladaras M., Zannis V.I., Kardassis D.

Mol. Biol. Cell 14:1279-1294(2003) GeneRIF 4089 · Mapped (17)
Results suggest that the transcriptional cross talk between the TGFbeta-regulated Smads 3 and 4 and hepatocyte nuclear factor-4 is mediated by specific functional domains in the two types of transcription factors. GeneRIF 4089

Sugano Y., Matsuzaki K., Tahashi Y., Furukawa F., Mori S., Yamagata H., Yoshida K., Matsushita M., Nishizawa M., Fujisawa J. et al.

Oncogene 22:2309-2321(2003) GeneRIF 4089 · Mapped (22)
Human HCC transfectants express a mutant Smad2(3S-A). Serine residues of SSXS motif were changed to alanine. They have impaired Smad2 signaling. Forced expression of Smad2(3S-A induced TGFB secretion & resistance to TGFB-induced growth inhibition. GeneRIF 4089

Shimotake T., Aoi S., Tomiyama H., Iwai N.

J. Pediatr. Surg. 38:694-697(2003) GeneRIF 4089 · Mapped (9)
results suggest carcinogenesis in the biliary tract epithelium in anomalous pancreaticobiliary ductal union (APBDU) is accompanied by multistep mutational events; inactivation of DPC-4 gene accumulates late in progression of biliary tract adenocarcinoma GeneRIF 4089

Lee P.S., Chang C., Liu D., Derynck R.

J. Biol. Chem. 278:27853-27863(2003) GeneRIF 4089 · Mapped (2)
Smad4 is sumoylated and has a role in the regulation of TGF-beta signaling through Smads GeneRIF 4089

Abraham S., Sawaya B.E., Safak M., Batuman O., Khalili K., Amini S.

Virology 309:196-202(2003) GeneRIF 4089 · Mapped (9)
Smad-4 had no effect on the basal activity of the MCP-1 promoter but showed the ability to decrease both Smad-3 and Tat-induced transcription of the MCP promoter in human astrocytic cells GeneRIF 4089

Moren A., Hellman U., Inada Y., Imamura T., Heldin C.H., Moustakas A.

J. Biol. Chem. 278:33571-33582(2003) GeneRIF 4089 · Mapped (2)
oligo-ubiquitination positively regulates Smad4 function whereas poly-ubiquitination primarily occurs in unstable cancer mutants and leads to protein degradation GeneRIF 4089

Nicolas F.J., Hill C.S.

Oncogene 22:3698-3711(2003) GeneRIF 4089 · Mapped (2)
duration of TGF-beta-Smad signaling is a critical determinant of the specificity of the TGF-beta response. GeneRIF 4089