Lehrnbecher T., Bernig T., Hanisch M., Koehl U., Behl M., Reinhardt D., Creutzig U., Klingebiel T., Chanock S.J., Schwabe D.

Leukemia 19:1745-1750(2005) GAD 119270 GeneRIF 1118 · Mapped (21)
Associated with INFECTION: bacterial infection; GAD 119270 Promoter variation in chitotriosidase is associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 1118

Altarescu G., Rudensky B., Abrahamov A., Goldfarb A., Rund D., Zimran A., Elstein D.

Am. J. Hematol. 71:7-10(2002) GeneRIF 1118 · Mapped (3)
In beta-thalassemia patients a significant correlation exists between plasma chitotriosidase & ferritin & with mean number of transfusions per year. Normal levels in children and increased levels in only some adults may reflect macrophage iron overload. GeneRIF 1118

Masoud M., Rudensky B., Elstein D., Zimran A.

Blood Cells Mol. Dis. 29:116-118(2002) GeneRIF 1118 · Mapped (3)
hypothesis that human chitotriosidase may have anti-fungal action was studied by ascertaining the prevalence of homozygosity for the mutation of chitotriosidase among survivors of Candida sepsis GeneRIF 1118

Artieda M., Cenarro A., Ganan A., Jerico I., Gonzalvo C., Casado J.M., Vitoria I., Puzo J., Pocovi M., Civeira F.

Arterioscler. Thromb. Vasc. Biol. 23:1645-1652(2003) GeneRIF 1118 · Mapped (3)
Increased serum chitotriosidase activity in individuals suffering from atherosclerosis is related to the severity of the atherosclerotic lesion and suggests a possible role of chitotriosidase as atherosclerotic extent marker. GeneRIF 1118

Hise A.G., Hazlett F.E., Bockarie M.J., Zimmerman P.A., Tisch D.J., Kazura J.W.

Genes Immun. 4:524-527(2003) GeneRIF 1118 · Mapped (5)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 1118

Gianfrancesco F., Musumeci S.

Cytogenet. Genome Res. 105:54-56(2004) GeneRIF 1118 · Mapped (3)
chitotriosidase is conserved across the evolutionary scale GeneRIF 1118

Brinkman J., Wijburg F.A., Hollak C.E., Groener J.E., Verhoek M., Scheij S., Aten J., Boot R.G., Aerts J.M.

J. Inherit. Metab. Dis. 28:13-20(2005) GeneRIF 1118 · Mapped (4)
chitotriosidase and CCL18 have roles in formation of pathological lipid-laden macrophages in type B Niemann-Pick disease GeneRIF 1118

Choi E.H., Taylor J.G., Foster C.B., Walsh T.J., Anttila V.J., Ruutu T., Palotie A., Chanock S.J.

Med. Mycol. 43:349-353(2005) GeneRIF 1118 GAD 119268 · Mapped (17)
Not Associated with INFECTION: candidiasis; GAD 119268 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 1118

Bierbaum S., Superti-Furga A., Heinzmann A.

Int. J. Immunogenet. 33:201-204(2006) GeneRIF 1118 · Mapped (3)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 1118

Malaguarnera L., Di Rosa M., Rosa M.D., Zambito A.M., dell'Ombra N., Di Marco R., Marco R.D., Malaguarnera M.

Am. J. Gastroenterol. 101:2060-2069(2006) GeneRIF 1118 · Mapped (3)
CHIT over-produced by Kupffer cells may contribute to the progression of hepatic fibrosis. GeneRIF 1118

Malaguarnera L.

Cell. Mol. Life Sci. 63:3018-3029(2006) GeneRIF 1118 · Mapped (3)
This review is looks at the key areas of investigations addressed to further illuminate whether ChT activation might have different functional meanings in various diseases. GeneRIF 1118

Piras I., Melis A., Ghiani M.E., Falchi A., Luiselli D., Moral P., Varesi L., Calo C.M., Vona G.

J. Hum. Genet. 52:110-116(2007) GeneRIF 1118 · Mapped (3)
Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 1118

Di Luca M., Romi R., Severini F., Toma L., Musumeci M., Fausto A.M., Mazzini M., Gambellini G., Musumeci S.

Parasitol. Res. 100:1033-1039(2007) GeneRIF 1118 · Mapped (3)
Formation of peritrophic membrane(PM) was complete at 16 h in the posterior midgut from Anopheles fed with healthy donor bloods; by contrast PM in mosquitoes fed with malaria and Gaucher patient bloods appeared clearly damaged at 20 and 24 h. GeneRIF 1118

Artieda M., Cenarro A., Ganan A., Lukic A., Moreno E., Puzo J., Pocovi M., Civeira F.

Cardiology 108:297-306(2007) GeneRIF 1118 · Mapped (3)
serum chitotriosidase activity predicts the risk of new cardiovascular events in the following 4 years. GeneRIF 1118

Wajner A., Michelin K., Burin M.G., Pires R.F., Pereira M.L., Giugliani R., Coelho J.C.

Clin. Biochem. 40:365-369(2007) GeneRIF 1118 · Mapped (3)
Plasma chitotriosidase activity in Gaucher disease GM1-gangliosidosis and Krabbe disease patients was respectively around 600-fold 15-fold and 12-fold greater than in normal individuals. GeneRIF 1118

Kurt I., Abasli D., Cihan M., Serdar M.A., Olgun A., Saruhan E., Erbil M.K.

Ann. N. Y. Acad. Sci. 1100:185-188(2007) GeneRIF 1118 · Mapped (3)
there are statistical differences between levels of chitotriosidase in elderly and young subjects GeneRIF 1118

Lee P., Waalen J., Crain K., Smargon A., Beutler E.

Blood Cells Mol. Dis. 39:353-360(2007) GeneRIF 1118 · Mapped (3)
Observational study of genotype prevalence. (HuGE Navigator); examination of allele frequency of subjects of European Asian & African ancestry compared to enzyme activity; investigated possibility that chitotriosidase deficiency was associated with tuberculosis or atopies GeneRIF 1118

Hall A.J., Quinnell R.J., Raiko A., Lagog M., Siba P., Morroll S., Falcone F.H.

Infect. Genet. Evol. 7:743-747(2007) GeneRIF 1118 · Mapped (3)
the CHIT1 genotype does not play a crucial role in protection against hookworm infection GeneRIF 1118

Piras I., Falchi A., Melis A., Ghiani M.E., Calo C.M., Varesi L., Vona G.

Exp. Mol. Pathol. 83:490-492(2007) GeneRIF 1118 · Mapped (3)
Observational study of gene-disease association. (HuGE Navigator); Results suggest that 24 bp duplication of CHIT1 gene is not correlated with CAD in Corsican population. GeneRIF 1118

van Eijk M., Scheij S.S., van Roomen C.P., Speijer D., Boot R.G., Aerts J.M.

FEBS Lett. 581:5389-5395(2007) GeneRIF 1118 · Mapped (11)
NOD2 activation but not toll-like receptor stimulation induces chitinase expression in macrophages GeneRIF 1118

Madazli R., Kucur M., Gezer A., Isman F., Bulut B.

Int J Gynaecol Obstet 100:239-243(2008) GeneRIF 1118 · Mapped (9)
activity in maternal and cord serum significantly higher in pre-eclamptic pregnancies GeneRIF 1118

Hall A.J., Morroll S., Tighe P., Gotz F., Falcone F.H.

Microbes Infect. 10:69-78(2008) GeneRIF 1118 · Mapped (3)
Human chitotriosidase is expressed in the eye and lacrimal gland and has an antimicrobial spectrum different from lysozyme. GeneRIF 1118

Bargagli E., Margollicci M., Perrone A., Luddi A., Perari M.G., Bianchi N., Refini R.M., Grosso S., Volterrani L., Rottoli P.

Sarcoidosis Vasc Diffuse Lung Dis 24:59-64(2007) GeneRIF 1118 · Mapped (3)
significantly different chitotriosidase concentrations were found in bronchoalveolar lavage (BAL) of sarcoidosis patients than controls especially in patients with progressing disease GeneRIF 1118

Brunner J.K., Scholl-Burgi S., Hossinger D., Wondrak P., Prelog M., Zimmerhackl L.B.

Rheumatol. Int. 28:949-950(2008) GeneRIF 1118 · Mapped (3)
in patients with Juvenile idiopathic arthritis: chitotriosidase level in synovial fluid was up to approximately 1 000 nmol/(h ml) at disease onset before therapy. The level in the sera was below 600 nmol/(h ml GeneRIF 1118

Tunc T., Kul M., Yaman H., Demirkaya E., Saldir M., Kurt I., Sarici S.U., Alpay F.

Clin. Biochem. 41:693-696(2008) GeneRIF 1118 · Mapped (3)
The higher chitotriosidase (ChT) activity in milk of mothers of premature infants than those of full-term infants suggests the presence of activated macrophages as the main source of ChT. GeneRIF 1118