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16 results for uniprot:Q12916Drop in citationmapping

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No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility.

Pociot F., Larsen Z.M., Zavattari P., Deidda E., Nerup J., Cattaneo M., Chiaramonte R., Comi P., Sabbadini M., Zollo M. et al.

Diabetes Metab. Res. Rev. 17:292-295(2001) GAD 134003 GeneRIF 6400 · Mapped (3)
Not Associated with IMMUNE: diabetes, type 1; 152 type 1 diatbetic-affected sib-pair families Denmark 240 families (229 simplex and 11 sib-pair families) Sardinia GAD 134003 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6400

SEL1L microsatellite polymorphism in Japanese patients with autoimmune thyroid diseases.

Ban Y., Taniyama M., Tozaki T., Yanagawa T., Tomita M., Ban Y.

Thyroid 11:335-338(2001) GeneRIF 6400 GAD 134001 · Mapped (3)
Not Associated with IMMUNE: autoimmune thyroid disease; thyroid disease, autoimmune; Case:114 unrelated female patients with Hashimoto's:thyroiditis:Japan;Case:133 unrelated female patients with Graves' disease:Japan;Control:179 unrelated women without clinical evidence or family history of any autoimmune disease:Japan GAD 134001 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6400

SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro.

Orlandi R., Cattaneo M., Troglio F., Casalini P., Ronchini C., Menard S., Biunno I.

Cancer Res. 62:567-574(2002) GeneRIF 6400 · Mapped (4)
SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro. GeneRIF 6400

Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population.

Chiaramonte R., Sabbadini M., Balordi F., Comi P., Sherbet G.V.

Mol. Cell. Biochem. 232:159-161(2002) GeneRIF 6400 · Mapped (3)
Observational study of genotype prevalence. (HuGE Navigator); Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population. GeneRIF 6400

Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture.

Chiaramonte R., Calzavara E., Basile A., Comi P., Sherbet G.V.

Anticancer Res. 22:4211-4214(2002) GeneRIF 6400 · Mapped (3)
Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture. GeneRIF 6400

Identification of a region within SEL1L protein required for tumour growth inhibition.

Cattaneo M., Canton C., Albertini A., Biunno I.

Gene 326:149-156(2004) GeneRIF 6400 · Mapped (3)
Region within SEL1L between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. GeneRIF 6400

SEL1L a multifaceted protein playing a role in tumor progression.

Biunno I., Cattaneo M., Orlandi R., Canton C., Biagiotti L., Ferrero S., Barberis M., Pupa S.M., Scarpa A., Menard S.

J. Cell. Physiol. 208:23-38(2006) GeneRIF 6400 · Mapped (3)
SEL1L has a very complex structure consisting of 21 exons featuring several alternative transcripts encoding for putative protein isoforms. Its complexity ensures protein flexibility and specificity. GeneRIF 6400

SEL1L affects human pancreatic cancer cell cycle and invasiveness through modulation of PTEN and genes related to cell-matrix interactions.

Cattaneo M., Fontanella E., Canton C., Delia D., Biunno I.

Neoplasia 7:1030-1038(2005) GeneRIF 6400 · Mapped (4)
SEL1L alters the expression of mediators involved in the remodeling of the extracellular matrix by creating a microenvironment that is unfavorable to invasive growth. GeneRIF 6400

A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease.

Saltini G., Dominici R., Lovati C., Cattaneo M., Michelini S., Malferrari G., Caprera A., Milanesi L., Finazzi D., Bertora P. et al.

Neurosci. Lett. 398:53-58(2006) GeneRIF 6400 · Mapped (3)
A possible role of the novel polymorphism as independent susceptibility factor of Alzheimer's dementia is shown GeneRIF 6400

A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes.

Kaneko M., Yasui S., Niinuma Y., Arai K., Omura T., Okuma Y., Nomura Y.

FEBS Lett. 581:5355-5360(2007) GeneRIF 6400 · Mapped (6)
endoplasmic reticulum stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways respectively GeneRIF 6400

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

Christianson J.C., Shaler T.A., Tyler R.E., Kopito R.R.

Nat. Cell Biol. 10:272-282(2008) GeneRIF 6400 · UniProtKB (6) · Mapped (15)
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD GeneRIF 6400

SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains.

Cattaneo M., Otsu M., Fagioli C., Martino S., Lotti L.V., Sitia R., Biunno I.

J. Cell. Physiol. 215:794-802(2008) GeneRIF 6400 · Mapped (6)
These findings reveal a role for SEL1L and HRD1 in IgM quality control. GeneRIF 6400

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

Hosokawa N., Wada I., Nagasawa K., Moriyama T., Okawa K., Nagata K.

J. Biol. Chem. 283:20914-20924(2008) GeneRIF 6400 · UniProtKB (5) · Mapped (5)
XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP GeneRIF 6400

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.

Mueller B., Klemm E.J., Spooner E., Claessen J.H., Ploegh H.L.

Proc. Natl. Acad. Sci. U.S.A. 105:12325-12330(2008) GeneRIF 6400 · UniProtKB (2) · Mapped (3)
identified AUP1 UBXD8 UBC6e and OS9 as functionally important components of this degradation complex formed by proteins that interact with SEL1L GeneRIF 6400

Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner.

Oresic K., Mueller B., Tortorella D.

Biosci. Rep. 29:173-181(2009) GeneRIF 6400 · Mapped (6)
knockdown of SEL1L [sel-1 suppressor of lin-12-like (Caenorhabditis elegans)] GeneRIF 6400

Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate.

Cattaneo M., Lotti L.V., Martino S., Cardano M., Orlandi R., Mariani-Costantini R., Biunno I.

J. Biol. Chem. 284:11405-11415(2009) GeneRIF 6400 · Mapped (3)
SEL1L-B and -C participate to novel molecular pathways that in parallel with ERAD contribute to the disposure of misfolded/unfolded or orphan proteins through degradation or secretion GeneRIF 6400

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