Sun H.X., Du W.N., Li Y.F., Zuo J., Wu G.D., Shen Y., Qiang B.Q., Yao Z.J., Hang J.M., Luo H.Y. et al.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:474-480(2002) GAD 133150 GeneRIF 5590 GAD 133149 · Mapped (5)
Associated with METABOLIC: diabetes, type 2; GAD 133150 GAD 133149 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5590

Mikosha A.S., Tron'ko N.D., Staren'kii D.V., Rybakov S.I.

Bull. Exp. Biol. Med. 132:841-843(2001) GeneRIF 5590 · Mapped (12)
Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors GeneRIF 5590

Siomboing X., Gressier B., Dine T., Brunet C., Luyckx M., Cazin M., Cazin J.C.

Farmaco 56:859-865(2001) GeneRIF 5590 · Mapped (6)
Investigation of the inhibitory effects of chelerythrine chloride on the translocation of the protein kinase C betaI betaII zeta in human neutrophils GeneRIF 5590

Banan A., Fields J.Z., Talmage D.A., Zhang L., Keshavarzian A.

Am. J. Physiol. Gastrointest. Liver Physiol. 282:G794-808(2002) GeneRIF 5590 · Mapped (5)
PKC-zeta is required in EGF protection of microtubules and intestinal barrier integrity against oxidant injury. GeneRIF 5590

San-Antonio B., Iniguez M.A., Fresno M.

J. Biol. Chem. 277:27073-27080(2002) GeneRIF 5590 · Mapped (16)
role of PKCzeta in T cells through the control of NFAT function by modulating the activity of its transactivation domain GeneRIF 5590

Fontayne A., Dang P.M., Gougerot-Pocidalo M.A., El-Benna J.

Biochemistry 41:7743-7750(2002) GeneRIF 5590 · Mapped (12)
PKC zeta expressed in human neutrophils can phosphorylate p47phox and induce both its translocation and NADPH oxidase activation as well as the binding of p47phox to the cytosolic fragment of p22phox. GeneRIF 5590

Slater S.J., Ho C., Stubbs C.D.

Chem. Phys. Lipids 116:75-91(2002) GeneRIF 5590 · Mapped (22)
REVIEW:Interaction of protein kinase C isozymes with membranes containing anionic phospholipids utilizing fluorescent phorbol esters to probe the properties of the C1 domains GeneRIF 5590

Plo I., Hernandez H., Kohlhagen G., Lautier D., Pommier Y., Laurent G.

J. Biol. Chem. 277:31407-31415(2002) GeneRIF 5590 · Mapped (13)
shows for the first time that topoisomerase II beta is a substrate for PKC zeta and that PKC zeta may significantly influence topoisomerase II inhibitor-induced cytotoxicity by altering topoisomerase II beta activity through its kinase function GeneRIF 5590

Banan A., Zhang L., Fields J.Z., Farhadi A., Talmage D.A., Keshavarzian A.

Am. J. Physiol. Gastrointest. Liver Physiol. 283:G909-22(2002) GeneRIF 5590 · Mapped (5)
EGF protects against oxidative disruption of the intestinal barrier by stabilizing the cytoskeleton in large part through the activation of PKC-zeta and downregulation of iNOS GeneRIF 5590

Cariou B., Perdereau D., Cailliau K., Browaeys-Poly E., Bereziat V., Vasseur-Cognet M., Girard J., Burnol A.F.

Mol. Cell. Biol. 22:6959-6970(2002) GeneRIF 5590 · Mapped (5)
The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta. GeneRIF 5590

Smith L., Smith J.B.

J. Biol. Chem. 277:45866-45873(2002) GeneRIF 5590 · Mapped (5)
catalytic domain of PKC zeta is intrinsically inactive and dependent on the transphosphorylation of the activation lo GeneRIF 5590

Bezombes C., de Thonel A., Apostolou A., Louat T., Jaffrezou J.P., Laurent G., Quillet-Mary A.

Mol. Pharmacol. 62:1446-1455(2002) GeneRIF 5590 · Mapped (5)
the role of PKCzeta in the negative regulation of drug-induced SM-CER pathway. GeneRIF 5590

Minami T., Abid M.R., Zhang J., King G., Kodama T., Aird W.C.

J. Biol. Chem. 278:6976-6984(2003) GeneRIF 5590 · Mapped (16)
Protein kinase C zeta-GATA-2 signaling regulates VCAM1 stimulation by thrombin in endothelial cells GeneRIF 5590

Dada L.A., Chandel N.S., Ridge K.M., Pedemonte C., Bertorello A.M., Sznajder J.I.

J. Clin. Invest. 111:1057-1064(2003) GeneRIF 5590 · Mapped (5)
hypoxia decreases Na K-ATPase activity in alveolar epithelial cells by triggering its endocytosis through mitochondrial reactive oxygen species and PKC-zeta-mediated phosphorylation of the Na K-ATPase alpha(1) subunit GeneRIF 5590

Di Liberto G., Dallot E., Eude-Le Parco I., Cabrol D., Ferre F., Breuiller-Fouche M.

Am. J. Physiol., Cell Physiol. 285:C599-607(2003) GeneRIF 5590 · Mapped (5)
PKC zeta has a role in the actin organization in ET-1-stimulated cells may play a role in myometrial contraction in pregnant women. GeneRIF 5590

Libersan D., Merhi Y.

Thromb. Haemost. 89:1016-1023(2003) GeneRIF 5590 · Mapped (28)
The novel varepsilon and eta and atypical zeta but not the conventional alpha and beta and the novel delta PKCs may be involved in the signaling pathways involved in thrombin-induced human platelet P-selectin expression GeneRIF 5590

Grunicke H.H., Spitaler M., Mwanjewe J., Schwaiger W., Jenny M., Ueberall F.

Adv. Enzyme Regul. 43:213-228(2003) GeneRIF 5590 · Mapped (14)
PKCzeta has a role in regulating cell survival in tumor cells GeneRIF 5590

Beeson M., Sajan M.P., Dizon M., Grebenev D., Gomez-Daspet J., Miura A., Kanoh Y., Powe J., Bandyopadhyay G., Standaert M.L. et al.

Diabetes 52:1926-1934(2003) GeneRIF 5590 · Mapped (5)
Defective aPKC activation contributes to skeletal muscle insulin resistance in glucose intolerance and type 2 diabetes GeneRIF 5590

Savkovic S.D., Koutsouris A., Hecht G.

Am. J. Physiol., Cell Physiol. 285:C512-21(2003) GeneRIF 5590 · Mapped (5)
enteropathogenic E coli infection of intestinal epithelial cells activates several signaling pathways including PKC zeta and ERK that lead to NF-kappa B activation thus ensuring the proinflammatory response. GeneRIF 5590

Sun H.X., Du W.N., Zuo J., Wu G.D., Shi G.B., Shen Y., Qiang B.Q., Yao Z.J., Hang J.M., Wang H. et al.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:223-227(2002) GeneRIF 5590 GAD 133151 · Mapped (7)
Associated with METABOLIC: diabetes, type 2; GAD 133151 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 5590

Laudanna C., Sorio C., Tecchio C., Butcher E.C., Bonora A., Bassi C., Scarpa A.

Lab. Invest. 83:1155-1163(2003) GeneRIF 5590 · Mapped (5)
disregulation of the function of atypical zeta PKC might be involved in the acquisition of an invasive and metastatic phenotype in pancreatic adenocarcinoma cells. GeneRIF 5590

Li Y.F., Sun H.X., Wu G.D., Du W.N., Zuo J., Shen Y., Qiang B.Q., Yao Z.J., Wang H., Huang W. et al.

World J. Gastroenterol. 9:2078-2082(2003) GeneRIF 5590 GAD 133146 · Mapped (5)
Associated with METABOLIC: diabetes, type 2; GAD 133146 PRKCZ gene may be associated with type 2 diabetes in Han population in North China. The haplotypes at five SNP sites in this gene may be responsible for this association. GeneRIF 5590

Tisdale E.J.

J. Biol. Chem. 278:52524-52530(2003) GeneRIF 5590 · UniProtKB (2) · Mapped (14)
protein kinase C iota/lambda binds to Rab 2 which inhibits aPKCiota/lambda-dependent GADPH phosphorylation [Protein kinase C lambda] GeneRIF 5590

Datta K., Li J., Bhattacharya R., Gasparian L., Wang E., Mukhopadhyay D.

Cancer Res. 64:456-462(2004) GeneRIF 5590 · Mapped (14)
PKCzeta is responsible for the activation of HIF-alpha by inhibiting the mRNA expression of FIH-1 thus promoting the transcription of hypoxia-inducible genes. GeneRIF 5590

Buether K., Plaas C., Barnekow A., Kremerskothen J.

Biochem. Biophys. Res. Commun. 317:703-707(2004) GeneRIF 5590 · UniProtKB (1) · Mapped (7)
identification of neuronal protein KIBRA as a novel substrate GeneRIF 5590