Kamimura D., Fu D., Matsuda Y., Atsumi T., Ohtani T., Park S.J., Ishihara K., Hirano T.

Genes Immun. 3:136-143(2002) GeneRIF 16195 MGI 96560 · Mapped (4)
results suggest that the Y759 point mutation in gp130 attenuates the early phase of defense against Listeria infection possibly owing to insufficient elevation of IFNgamma levels and thus gp130 is a possible candidate gene for Listeria susceptibility GeneRIF 16195

Hatta T., Moriyama K., Nakashima K., Taga T., Otani H.

J. Neurosci. 22:5516-5524(2002) GeneRIF 16195 MGI 96560 · Mapped (4)
The Role of gp130 in cerebral cortical development GeneRIF 16195

Jenkins B.J., Quilici C., Roberts A.W., Grail D., Dunn A.R., Ernst M.

Exp. Hematol. 30:1248-1256(2002) GeneRIF 16195 MGI 96560 · Mapped (4)
gp130-mediated STAT1/3 activation is needed for the normal balance of hematopoietic progenitors during fetal & adult life. This activation has 2 roles 1) restricting production of immature progenitors; 2) promoting megakaryocyte maturation. GeneRIF 16195

Ishihara K., Atsumi T.

Tanpakushitsu Kakusan Koso 47:2336-2342(2002) GeneRIF 16195 · Mapped (4)
its abnormal signaling causes autoimmune diseases--review GeneRIF 16195

Takizawa M., Nobuhisa I., Igarashi K., Ueno M., Nakashima K., Kitamura T., Taga T.

Exp. Hematol. 31:283-289(2003) GeneRIF 16195 · Mapped (11)
gp130 plays an indispensable role in the expansion of hematopoietic precursor cells in the fetal mouse aorta-gonad-mesonephros GeneRIF 16195

Lang R., Pauleau A.L., Parganas E., Takahashi Y., Mages J., Ihle J.N., Rutschman R., Murray P.J.

Nat. Immunol. 4:546-550(2003) GeneRIF 16195 · Mapped (6)
SOCS3 regulates the plasticity of gp130 signaling. GeneRIF 16195

Streetz K.L., Wustefeld T., Klein C., Kallen K.J., Tronche F., Betz U.A., Schutz G., Manns M.P., Muller W., Trautwein C.

Gastroenterology 125:532-543(2003) GeneRIF 16195 MGI 96560 · Mapped (4)
gp130 has an essential role in controlling acute phase gene expression and provides hepatocellular protection after LPS challange. GeneRIF 16195

Choi J.S., Kim S.Y., Park H.J., Cha J.H., Choi Y.S., Kang J.E., Chung J.W., Chun M.H., Lee M.Y.

Brain Res. Mol. Brain Res. 119:10-18(2003) GeneRIF 16195 · Mapped (6)
Two signaling pathways involving gp130 STATs and MAPK were activated in reactive astrocytes after KA injection indicating that STATs and MAPK may mediate the astroglial reaction in the rat hippocampus after KA-induced seizures. GeneRIF 16195

Kamaraju A.K., Adjalley S., Zhang P., Chebath J., Revel M.

J. Biol. Chem. 279:3852-3861(2004) GeneRIF 16195 · Mapped (11)
gp130 signaling induces C/EBP-delta GeneRIF 16195

Shin H.I., Divieti P., Sims N.A., Kobayashi T., Miao D., Karaplis A.C., Baron R., Bringhurst R., Kronenberg H.M.

Endocrinology 145:1376-1385(2004) GeneRIF 16195 MGI 96560 · Mapped (17)
importance of gp130 signaling for osteoblast function and calcium homeostasis. GeneRIF 16195

Jenkins B.J., Grail D., Inglese M., Quilici C., Bozinovski S., Wong P., Ernst M.

Mol. Cell. Biol. 24:1453-1463(2004) GeneRIF 16195 · Mapped (22)
correlation between gp130-dependent ERK MAP kinase signaling and c-fms gene activation GeneRIF 16195

Sriram K., Benkovic S.A., Hebert M.A., Miller D.B., O'Callaghan J.P.

J. Biol. Chem. 279:19936-19947(2004) GeneRIF 16195 · Mapped (14)
gp130-mediated activation of JAK2/STAT3 signaling pathway may play a key role in the induction of astrogliosis GeneRIF 16195

Scheller J., Schuster B., Holscher C., Yoshimoto T., Rose-John S.

Biochem. Biophys. Res. Commun. 326:724-728(2005) GeneRIF 16195 · Mapped (12)
results show that soluble gp130-Fc does not interfere with IL-27 signaling; conclude that that IL-27 does not bind with high affinity to gp130 GeneRIF 16195

Gregg C., Weiss S.

Development 132:565-578(2005) GeneRIF 16195 · Mapped (89)
demonstrate a novel region-specific role for CNTF/leukemia inhibitory factor/gp130 signaling in the development of the germinal layers of the embryonic telencephalon GeneRIF 16195

Jenkins B.J., Roberts A.W., Najdovska M., Grail D., Ernst M.

Blood 105:3512-3520(2005) GeneRIF 16195 MGI 96560 · Mapped (12)
gp130-dependent STAT3 hyperactivation during hematopoiesis has pathological consequences affecting multiple organs; identify the threshold of STAT3 signaling elicited by IL-6 family cytokines as a critical determinant for hematopoietic homeostasis GeneRIF 16195

Suzuki S., Yamashita T., Tanaka K., Hattori H., Sawamoto K., Okano H., Suzuki N.

J. Cereb. Blood Flow Metab. 25:685-693(2005) GeneRIF 16195 · Mapped (4)
Leukemia inhibitory factor receptor and gp130 were expressed in neurons and the ischemic damage of these proteins was rescued in the high-LIF group GeneRIF 16195

Klein C., Wustefeld T., Assmus U., Roskams T., Rose-John S., Muller M., Manns M.P., Ernst M., Trautwein C.

J. Clin. Invest. 115:860-869(2005) GeneRIF 16195 MGI 96560 · Mapped (11)
Data show that IL-6-gp130-STAT3-dependent gene expression in hepatocytes mediates IL-6-triggered protection in immune-mediated Con A-induced hepatitis. GeneRIF 16195

Lodge P., McWhir J., Gallagher E., Sang H.

Cloning Stem Cells 7:2-7(2005) GeneRIF 16195 · Mapped (11)
in mouse CBA blastocysts gp130 signaling has a role in STAT3 activation GeneRIF 16195

Wuestefeld T., Klein C., Streetz K.L., Beraza N., Scholmerich J., Burgart L.J., Zender L., Kubicka S., Baskin-Bey E., Gores G.J. et al.

Hepatology 42:1082-1090(2005) GeneRIF 16195 · Mapped (4)
During acute and chronic cholestasis gp130 is essential for controlling acute-phase response. Lack of gp130 results in pronounced bacterial growth in bile and liver after bile duct ligation associated with higher mortality. GeneRIF 16195

Stanke M., Duong C.V., Pape M., Geissen M., Burbach G., Deller T., Gascan H., Otto C., Parlato R., Schutz G. et al.

Development 133:141-150(2006) GeneRIF 16195 MGI 96560 · Mapped (4)
gp 130-signaling plays an essential role in the target-dependent specification of the cholinergic neurotransmitter phenotype. GeneRIF 16195

Sawa S., Kamimura D., Jin G.H., Morikawa H., Kamon H., Nishihara M., Ishihara K., Murakami M., Hirano T.

J. Exp. Med. 203:1459-1470(2006) GeneRIF 16195 MGI 96560 · Mapped (53)
IL-7 antibody treatment inhibited not only the enhanced homeostatic proliferation but also the autoimmune arthritis in gp130 mutant mice as a result of interleukin (IL)-6 receptor gp130 signaling.(IL-6receptor gp130) GeneRIF 16195

Kim S., Yamazaki M., Shevde N.K., Pike J.W.

Mol. Endocrinol. 21:197-214(2007) GeneRIF 16195 · Mapped (23)
activation of RankL gene expression by PKA- and gp130-inducers is mediated via common regulatory domains that also served to facilitate the activity of 1 25-(OH)2D3 GeneRIF 16195

Ash J.D., Graham D.R.

Adv. Exp. Med. Biol. 572:147-153(2006) GeneRIF 16195 · Mapped (8)
leukemia inhibitory factor regulates both rod and cone gene expression while Gp130 regulates cone gene expression GeneRIF 16195

Yeoh G.C., Ernst M., Rose-John S., Akhurst B., Payne C., Long S., Alexander W., Croker B., Grail D., Matthews V.B.

Hepatology 45:486-494(2007) GeneRIF 16195 · Mapped (20)
The models depict gp130-mediated hyperactive ERK-1/2 signaling hyperactive STAT-3 signaling and Socs-3 or active ERK-1/2 as well as active STAT-3 signaling in oval cell proliferation. GeneRIF 16195

Choi J.W., Kim J.T., Park J.H., Park E.K., Kim S.Y., Kwon T.G., Kim E.C., Shin H.I.

Exp. Mol. Med. 39:295-303(2007) GeneRIF 16195 · Mapped (4)
gp130-mediated signaling is important for the normal morphogenesis of Meckel's cartilage and subsequent mandibular development. GeneRIF 16195