Grundler R., Thiede C., Miething C., Steudel C., Peschel C., Duyster J.

Blood 102:646-651(2003) GeneRIF 14255 · Mapped (5)
Both deletion of Ileu 836 & an Ileu 836 -->Met plus an Arg insertion cause constitutive activation & auto phosphorylation of FLT3. Both mutants have transforming capabilities. GeneRIF 14255

Karsunky H., Merad M., Cozzio A., Weissman I.L., Manz M.G.

J. Exp. Med. 198:305-313(2003) GeneRIF 14255 · Mapped (5)
common lymphoid and common myeloid progenitors as well as steady state dendritic cells in thymus spleen and epidermis express Flt3 GeneRIF 14255

Streeter P.R., Dudley L.Z., Fleming W.H.

Exp. Hematol. 31:1119-1125(2003) GeneRIF 14255 · Mapped (8)
receptors provides a high degree of radioprotection to the hematopoietic progenitor cell and stem cell compartment. GeneRIF 14255

Grundler R., Miething C., Thiede C., Peschel C., Duyster J.

Blood 105:4792-4799(2005) GeneRIF 14255 · Mapped (5)
FLT3-tyrosine kinase domain mutations may not have a role in progression of acute myeloid leukemia while internal tandem duplications may have a role in myeloproliferative disease GeneRIF 14255

Wang G.G., Pasillas M.P., Kamps M.P.

Blood 106:254-264(2005) GeneRIF 14255 · Mapped (7)
transcription factor oncoprotein (Meis1) that establishes expression of a tyrosine kinase oncoprotein (FLT3) GeneRIF 14255

Ishiko J., Mizuki M., Matsumura I., Shibayama H., Sugahara H., Scholz G., Serve H., Kanakura Y.

Oncogene 24:8144-8153(2005) GeneRIF 14255 · Mapped (5)
Three Tyr --> Phe mutations inhibited the constitutive activation of other FLT3 mutants bearing internal tandem duplication. GeneRIF 14255

Whartenby K.A., Calabresi P.A., McCadden E., Nguyen B., Kardian D., Wang T., Mosse C., Pardoll D.M., Small D.

Proc. Natl. Acad. Sci. U.S.A. 102:16741-16746(2005) GeneRIF 14255 · Mapped (5)
hypothesized that inhibition of FLT3 signaling would thus produce an inhibition of dendritic cell-induced stimulation of T cells thereby inhibiting autoimmune responses GeneRIF 14255

Holmes M.L., Carotta S., Corcoran L.M., Nutt S.L.

Genes Dev. 20:933-938(2006) GeneRIF 14255 MGI 95559 · Mapped (21)
transcription in B-cell progenitors is repressed by Pax5 GeneRIF 14255

Fukuda S., Pelus L.M.

Exp. Hematol. 34:1041-1051(2006) GeneRIF 14255 · Mapped (7)
functional interactions between Flt3 and SDF1alpha/CXCR4 regulate oncogenic proliferation and migration of hematopoietic cells which is mediated by Ras and that Flt3 signaling regulates hematopoietic cell trafficking in vivo. GeneRIF 14255

Schwarz B.A., Sambandam A., Maillard I., Harman B.C., Love P.E., Bhandoola A.

J. Immunol. 178:2008-2017(2007) GeneRIF 14255 · Mapped (14)
fms-like tyrosine kinase receptor-3 signaling is required for the generation of T lineage-competent progenitors which selectively express molecules including CCR9 GeneRIF 14255

Choudhary C., Brandts C., Schwable J., Tickenbrock L., Sargin B., Ueker A., Bohmer F.D., Berdel W.E., Muller-Tidow C., Serve H.

Blood 110:370-374(2007) GeneRIF 14255 · Mapped (12)
Flt3-ITD-induced STAT5 activation is independent of Src or Jak kinases. STAT5 is a direct target of Flt3 GeneRIF 14255

Sitnicka E., Buza-Vidas N., Ahlenius H., Cilio C.M., Gekas C., Nygren J.M., Mansson R., Cheng M., Jensen C.T., Svensson M. et al.

Blood 110:2955-2964(2007) GeneRIF 14255 · Mapped (12)
a key role of FLT3 signaling in regulating the very earliest stages of lymphoid progenitors. GeneRIF 14255

Stubbs M.C., Armstrong S.A.

Curr Drug Targets 8:703-714(2007) GeneRIF 14255 · Mapped (7)
highlights the role of FLT3 in hematopoiesis and how when activated it may play a role in the development of acute myeloid or acute lymphoblastic leukemia GeneRIF 14255

Lu Y., Kitaura J., Oki T., Komeno Y., Ozaki K., Kiyono M., Kumagai H., Nakajima H., Nosaka T., Aburatani H. et al.

Leukemia 21:2246-2257(2007) GeneRIF 14255 · Mapped (17)
TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD GeneRIF 14255

Kim H.G., Kojima K., Swindle C.S., Cotta C.V., Huo Y., Reddy V., Klug C.A.

Blood 111:1567-1574(2008) GeneRIF 14255 · Mapped (5)
FLT3-activating mutations can cooperate with core binding factor beta-smooth muscle myosin heavy chain in an animal model of inv(16)-associated acute myeloid leukemia GeneRIF 14255

Sallmyr A., Fan J., Datta K., Kim K.T., Grosu D., Shapiro P., Small D., Rassool F.

Blood 111:3173-3182(2008) GeneRIF 14255 · Mapped (7)
aggressiveness of the disease and poor prognosis of AML patients with FLT3/ITD mutations could be the result of increased genomic instability GeneRIF 14255

Li L., Piloto O., Nguyen H.B., Greenberg K., Takamiya K., Racke F., Huso D., Small D.

Blood 111:3849-3858(2008) GeneRIF 14255 MGI 95559 · Mapped (6)
Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model GeneRIF 14255

Muller J.P., Schonherr C., Markova B., Bauer R., Stocking C., Bohmer F.D.

Leukemia 22:1945-1948(2008) GeneRIF 14255 · Mapped (9)
alternate signaling downstream of FLT3-ITD is associated with a reduced requirement of SHP2 for promoting cell proliferation and transformation. GeneRIF 14255

Huang Y., Ratajczak M.Z., Reca R., Xu H., Tanner M., Rezzoug F., Hussain L.R., Fugier-Vivier I., Bolli R., Ildstad S.T.

Transplantation 85:1175-1184(2008) GeneRIF 14255 · Mapped (5)
Fms-related tyrosine kinase 3 expression discriminates hematopoietic stem cells subpopulations with differing engraftment-potential. GeneRIF 14255

Vempati S., Reindl C., Wolf U., Kern R., Petropoulos K., Naidu V.M., Buske C., Hiddemann W., Kohl T.M., Spiekermann K.

Clin. Cancer Res. 14:4437-4445(2008) GeneRIF 14255 · Mapped (5)
We identified two tyrosine residues Y589 and Y591 in the juxtamembrane domain that are critical for the ligand-dependent activation of FLT3-WT and the transforming potential of oncogenic FLT3 mutants. GeneRIF 14255

Lambrecht B.N., Hammad H.

Chem Immunol Allergy 94:189-200(2008) GeneRIF 14255 · Mapped (14)
induces differentiation of plasmacytoid dendritic cells; administration to sensitized mice reduses all the features of asthma GeneRIF 14255

Perugini M., Kok C.H., Brown A.L., Wilkinson C.R., Salerno D.G., Young S.M., Diakiw S.M., Lewis I.D., Gonda T.J., D'Andrea R.J.

Leukemia 23:729-738(2009) GeneRIF 14255 · Mapped (9)
identified Gadd45alpha as a downregulated gene in response to constitutive signaling from two FLT3 mutants (FLT3-ITD and FLT3-TKD) commonly found in AML and a leukemogenic GM-CSF receptor trans-membrane mutant GeneRIF 14255

Auffray C., Fogg D.K., Narni-Mancinelli E., Senechal B., Trouillet C., Saederup N., Leemput J., Bigot K., Campisi L., Abitbol M. et al.

J. Exp. Med. 206:595-606(2009) GeneRIF 14255 · Mapped (22)
CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection. GeneRIF 14255

Yamaguchi H., Hanawa H., Uchida N., Inamai M., Sawaguchi K., Mitamura Y., Shimada T., Dan K., Inokuchi K.

Exp. Hematol. 37:701-714(2009) GeneRIF 14255 · Mapped (15)
enhancement of S100A6 expression plays an important role in MLL-AF4-associated leukemogenesis GeneRIF 14255

Razumovskaya E., Masson K., Khan R., Bengtsson S., Ronnstrand L.

Exp. Hematol. 37:979-989(2009) GeneRIF 14255 · UniProtKB (1) · Mapped (5)
quantitative changes and qualitative differences in the phosphorylation patterns eight phosphorylated tyrosines (pY589 pY591 pY599 pY726 pY768 pY793 pY842 and pY955) receptors of the wild-type and the mutated Flt3 GeneRIF 14255