Fujimori A., Hashimoto H., Araki R., Saito T., Sato S., Kasama Y., Tsutsumi Y., Mori M., Fukumura R., Ohhata T. et al.

Radiat. Res. 157:298-305(2002) GeneRIF 19090 · UniProtKB (1) · Mapped (3)
the nucleotide sequence of approximately 193-kbp and 84-kbp genomic regions encoding the entire Prkdc gene GeneRIF 19090

Woo R.A., Jack M.T., Xu Y., Burma S., Chen D.J., Lee P.W.

EMBO J. 21:3000-3008(2002) GeneRIF 19090 · Mapped (21)
required for p53-dependent apoptosis in mouse embryo fibroblasts GeneRIF 19090

Takahashi A., Asakawa I., Yuki K., Matsumoto T., Kumamoto M., Kondo N., Ohnishi K., Tachibana A., Ohnishi T.

Int. J. Radiat. Biol. 78:689-693(2002) GeneRIF 19090 · Mapped (3)
DNA-PK role in radioadaptive response of mouse spleen GeneRIF 19090

Degg N.L., Weil M.M., Edwards A., Haines J., Coster M., Moody J., Ellender M., Cox R., Silver A.

Cancer Res. 63:2361-2363(2003) GeneRIF 19090 MGI 104779 · Mapped (15)
Evidence is found that chromosome 16 segments from BALB/c that encode Prkdc interact with Apc(Min) (multiple intestinal neoplasia) and specifically enhance IR-induced adenoma development in the upper part of the small intestine. GeneRIF 19090

Blackburn A.C., Brown J.S., Naber S.P., Otis C.N., Wood J.T., Jerry D.J.

Cancer Res. 63:2364-2368(2003) GeneRIF 19090 MGI 104779 · Mapped (14)
BALB/c alleles for Prkdc and Cdkn2a interact to modify mammary tumor susceptibility in Trp53+/- mice. GeneRIF 19090

Faiola B., Bauer A.K., Fuller E.S., Wong V.A., Pluta L.J., Abernethy D.J., Mangum J.B., Everitt J.I., Recio L.

Toxicol. Sci. 75:321-332(2003) GeneRIF 19090 · Mapped (3)
Prkdc does not appear to be a significant genetic susceptibility factor for acute benzene toxicity in mice. GeneRIF 19090

Jack M.T., Woo R.A., Motoyama N., Takai H., Lee P.W.

J. Biol. Chem. 279:15269-15273(2004) GeneRIF 19090 · Mapped (21)
DNA damage causes an immediate and sequential modification of latent p53 by DNA-PK and Chk2 which under appropriate conditions can lead to apoptosis GeneRIF 19090

Feng J., Park J., Cron P., Hess D., Hemmings B.A.

J. Biol. Chem. 279:41189-41196(2004) GeneRIF 19090 · Mapped (5)
DNA-PK has a role in the Ser-473 phosphorylation step in the activation of PKB GeneRIF 19090

Rooney S., Alt F.W., Sekiguchi J., Manis J.P.

Proc. Natl. Acad. Sci. U.S.A. 102:2471-2475(2005) GeneRIF 19090 · Mapped (8)
DNA-PK has Artemis-independent functions in class switch recombination and normal development GeneRIF 19090

Lebrun P., Montminy M.R., Van Obberghen E.

J. Biol. Chem. 280:38203-38210(2005) GeneRIF 19090 · Mapped (3)
the pancreatic duodenal homeobox-1 protein is regulated by DNA-dependent protein kinase GeneRIF 19090

Neema M., Navarro-Quiroga I., Chechlacz M., Gilliams-Francis K., Liu J., Lamonica K., Lin S.L., Naegele J.R.

Hippocampus 15:1057-1071(2005) GeneRIF 19090 · Mapped (3)
role in neuroprotection in kainic acid-induced seizures GeneRIF 19090

Wong K.K., Maser R.S., Sahin E., Bailey S.T., Xia H., Ji H., McNamara K., Naylor M., Bronson R.T., Ghosh S. et al.

Oncogene 26:2815-2821(2007) GeneRIF 19090 · Mapped (3)
The combination of DNA-PKcs deficiency and telomere dysfunction resulted in a shortened lifespan that was reduced further following viral infection or experimental activation of the innate immune response. GeneRIF 19090

Maser R.S., Wong K.K., Sahin E., Xia H., Naylor M., Hedberg H.M., Artandi S.E., DePinho R.A.

Mol. Cell. Biol. 27:2253-2265(2007) GeneRIF 19090 MGI 104779 · Mapped (16)
DNA-dependent protein kinase deficiency does not reduce apoptosis tissue atrophy or p53 activation in late-generation mTerc(-/-) tissues but rather moderately exacerbates germ cell apoptosis and testicular degeneration GeneRIF 19090

Costantini S., Woodbine L., Andreoli L., Jeggo P.A., Vindigni A.

DNA Repair (Amst.) 6:712-722(2007) GeneRIF 19090 · Mapped (13)
DNA-PK kinase activity results in disassembly of the Ku/DNA ligase IV/Xrcc4 complex GeneRIF 19090

Zayed H., Xia L., Yerich A., Yant S.R., Kay M.A., Puttaraju M., McGarrity G.J., Wiest D.L., McIvor R.S., Tolar J. et al.

Mol. Ther. 15:1273-1279(2007) GeneRIF 19090 · Mapped (3)
Sleeping Beauty-based trans-splicing vectors should prove useful in facilitating the correction of endogenous mutated mRNA transcripts including the DNA-PKcs defect present in severe combined immune deficiency cells GeneRIF 19090

Inagaki K., Ma C., Storm T.A., Kay M.A., Nakai H.

J. Virol. 81:11304-11321(2007) GeneRIF 19090 · Mapped (7)
DNA-PKcs and Artemis open AAV inverted terminal repeat (ITR) hairpin loops in a tissue-dependent manner. GeneRIF 19090

Franco S., Murphy M.M., Li G., Borjeson T., Boboila C., Alt F.W.

J. Exp. Med. 205:557-564(2008) GeneRIF 19090 MGI 104779 · Mapped (29)
under specific activation conditions DNA-PKcs(-/-) B cells with chromosomal breaks are eliminated or at least prevented from progressing to metaphase via a p53-dependent response GeneRIF 19090

Bozulic L., Surucu B., Hynx D., Hemmings B.A.

Mol. Cell 30:203-213(2008) GeneRIF 19090 · Mapped (6)
PKB acts downstream of DNA-PK in the DNA damage response signaling cascade where it provides a prosurvival signal in particular by affecting transcriptional p21 regulation. GeneRIF 19090

Surucu B., Bozulic L., Hynx D., Parcellier A., Hemmings B.A.

J. Biol. Chem. 283:30025-30033(2008) GeneRIF 19090 MGI 104779 · Mapped (12)
analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis GeneRIF 19090

Stracker T.H., Williams B.R., Deriano L., Theunissen J.W., Adelman C.A., Roth D.B., Petrini J.H.

Mol. Cell. Biol. 29:503-514(2009) GeneRIF 19090 MGI 104779 · Mapped (23)
results reveal a role for DNA-PKcs in the maintenance of S/G(2)-phase chromosome stability and in the induction of cell cycle checkpoint responses GeneRIF 19090

Hasegawa M., Kurata M., Yamamoto K., Yoshida K., Aizawa S., Kitagawa M.

Leuk. Res. 33:1100-1107(2009) GeneRIF 19090 · Mapped (32)
gp70 enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus and MCM2 resulting in the activation of DNA-PK to phosphorylate P53. GeneRIF 19090

Park J., Feng J., Li Y., Hammarsten O., Brazil D.P., Hemmings B.A.

J. Biol. Chem. 284:6169-6174(2009) GeneRIF 19090 · Mapped (13)
the specificity of DNA-PK action as a Ser-473 kinase for PKB in DNA repair signaling. GeneRIF 19090

Hossain M.B., Ji P., Anish R., Jacobson R.H., Takada S.

J. Biol. Chem. 284:8621-8632(2009) GeneRIF 19090 · Mapped (49)
NRF-1 can also directly interact with poly(ADP-ribose) polymerase 1 (PARP-1) and co-purify the PARP-1.DNA-PK.Ku80.Ku70.topoisomerase IIbeta-containing protein complex. GeneRIF 19090

Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S.

Cell 136:1056-1072(2009) GeneRIF 19090 · Mapped (3)
In DNA-PK-deficient SCID mice feeding-induced USF-1 phosphorylation/acetylation DNA breaks and FAS activation leading to lipogenesis are impaired resulting in decreased triglyceride levels. GeneRIF 19090

Callen E., Jankovic M., Wong N., Zha S., Chen H.T., Difilippantonio S., Di Virgilio M., Heidkamp G., Alt F.W., Nussenzweig A. et al.

Mol. Cell 34:285-297(2009) GeneRIF 19090 MGI 104779 · Mapped (35)
Results reveal a DNA-PKcs-dependent pathway that regulates DNA repair and activation of p53 in the absence of ATM. GeneRIF 19090