Mavaddat N., Dunning A.M., Ponder B.A., Easton D.F., Pharoah P.D.

Cancer Epidemiol. Biomarkers Prev. 18:255-259(2009) GAD 567655 GeneRIF 6868 · Mapped (744)
Not Associated with CANCER: breast cancer ; GAD 567655 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 6868

Lee M.H., Verma V., Maskos K., Nath D., Knauper V., Dodds P., Amour A., Murphy G.

Biochem. J. 364:227-234(2002) GeneRIF 6868 · Mapped (12)
Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme GeneRIF 6868

Gomez-Gaviro M.V., Gonzalez-Alvaro I., Dominguez-Jimenez C., Peschon J., Black R.A., Sanchez-Madrid F., Diaz-Gonzalez F.

J. Biol. Chem. 277:38212-38221(2002) GeneRIF 6868 · Mapped (12)
Data show that tumor necrosis factor-alpha-converting enzyme (TACE)is involved in the shedding of L-selectin by NSAIDS in human neutrophils. GeneRIF 6868

Zheng Y., Schlondorff J., Blobel C.P.

J. Biol. Chem. 277:42463-42470(2002) GeneRIF 6868 MINT MINT-108290 MINT MINT-108290 · Mapped (22)
MINT-58311. ADAM17 (uniprotkb:P78536) physically interacts (MI:0915) with PTPN3 (uniprotkb:P26045) by two hybrid (MI:0018). From mint MINT MINT-108290 MINT-58317. ADAM17 (uniprotkb:P78536-1) physically interacts (MI:0915) with PTPN3 (uniprotkb:P26045) by anti tag coimmunoprecipitation (MI:0007). From mint MINT MINT-108290 regulated by protein tyrosine phosphatase PTPH1 GeneRIF 6868

Seifert T., Kieseier B.C., Ropele S., Strasser-Fuchs S., Quehenberger F., Fazekas F., Hartung H.P.

Mult. Scler. 8:447-451(2002) GeneRIF 6868 · Mapped (8)
multiple sclerosis patients found positive for TACE mRNA in PBMCs showed a significantly higher mean number of new lesions GeneRIF 6868

Asai M., Hattori C., Szabo B., Sasagawa N., Maruyama K., Tanuma S., Ishiura S.

Biochem. Biophys. Res. Commun. 301:231-235(2003) GeneRIF 6868 · Mapped (11)
The results indicate that ADAM9 ADAM10 and ADAM17 members of the disintegrin and metalloprotease family catalyze alpha-secretory cleavage and therefore act as alpha-secretases in A172 cells. GeneRIF 6868

Basbaum C., Li D., Gensch E., Gallup M., Lemjabbar H.

Novartis Found. Symp. 248:171-176(2002) GeneRIF 6868 · Mapped (36)
Review. The activation of EGFR in response to smoke involves cleavage of amphiregulin by ADAM 17. GeneRIF 6868

Borrell-Pages M., Rojo F., Albanell J., Baselga J., Arribas J.

EMBO J. 22:1114-1124(2003) GeneRIF 6868 · Mapped (8)
Data show that tumor necrosis factor-alpha converting enzyme (TACE) is required for epidermal growth factor receptor activation in vivo and for the development of tumors in nude mice indicating a crucial role of TACE in tumorigenesis. GeneRIF 6868

Peiretti F., Deprez-Beauclair P., Bonardo B., Aubert H., Juhan-Vague I., Nalbone G.

J. Cell. Sci. 116:1949-1957(2003) GeneRIF 6868 MINT MINT-108290 MINT MINT-108290 MINT MINT-108290 MINT MINT-108290 MINT MINT-108290 MINT MINT-108290 MINT MINT-108290 · Mapped (14)
MINT-1901710. ADAM17 (uniprotkb:P78536) physically interacts (MI:0915) with DLG1 (uniprotkb:Q12959) by two hybrid pooling approach (MI:0398). From mint MINT MINT-108290 MINT-1901743. ADAM17 (uniprotkb:P78536) physically interacts (MI:0915) with DLG1 (uniprotkb:Q12959) by gst pull down (MI:0059). From mint MINT MINT-108290 MINT-1901775. DLG1 (uniprotkb:Q12959) physically interacts (MI:0915) with ADAM17 (uniprotkb:P78536) by anti bait coimmunoprecipitation (MI:0006). From mint MINT MINT-108290 MINT-1901801. DLG1 (uniprotkb:Q12959) physically interacts (MI:0915) with ADAM17 (uniprotkb:P78536) by anti tag coimmunoprecipitation (MI:0007). From mint MINT MINT-108290 MINT-1901824. ADAM17 (uniprotkb:P78536) physically interacts (MI:0915) with DLG1 (uniprotkb:Q12959) by anti tag coimmunoprecipitation (MI:0007). From mint MINT MINT-108290 MINT-1901856. DLG1 (uniprotkb:Q12959) and ADAM17 (uniprotkb:P78536) colocalize (MI:0403) by fluorescence microscopy (MI:0416). From mint MINT MINT-108290 MINT-1901891. DLG1 (uniprotkb:Q12959) and ADAM17 (uniprotkb:P78536) colocalize (MI:0403) by colocalization by immunostaining (MI:0022). From mint MINT MINT-108290 TACE binds to SAP97 which may have a role in the regulation of TACE shedding activity GeneRIF 6868

Peiretti F., Canault M., Deprez-Beauclair P., Berthet V., Bonardo B., Juhan-Vague I., Nalbone G.

Exp. Cell Res. 285:278-285(2003) GeneRIF 6868 · Mapped (8)
Intracellular maturation and transport of TACE. GeneRIF 6868

Lemjabbar H., Li D., Gallup M., Sidhu S., Drori E., Basbaum C.

J. Biol. Chem. 278:26202-26207(2003) GeneRIF 6868 · Mapped (20)
ADAM-17 has a role in stimulation of lung epithelial cells upon exposure to tobacco smoke by cleaving amphiregulin which binds to EGF receptor GeneRIF 6868

Borroto A., Ruiz-Paz S., de la Torre T.V., Borrell-Pages M., Merlos-Suarez A., Pandiella A., Blobel C.P., Baselga J., Arribas J.

J. Biol. Chem. 278:25933-25939(2003) GeneRIF 6868 · UniProtKB (1) · Mapped (8)
TACE has a role in protein ectodomain shedding GeneRIF 6868

Kieseier B.C., Pischel H., Neuen-Jacob E., Tourtellotte W.W., Hartung H.P.

Glia 42:398-405(2003) GeneRIF 6868 · Mapped (11)
under inflammatory conditions ADAM-10 expressed by perivascular macrophages and ADAM-17 expressed by invading T cells may actively contribute to the pathogenesis of inflammatory disorders of the CNS. GeneRIF 6868

Gschwind A., Hart S., Fischer O.M., Ullrich A.

EMBO J. 22:2411-2421(2003) GeneRIF 6868 · Mapped (10)
Data show that in squamous cell carcinoma cells stimulation with G protein-coupled receptor agonists specifically results in cleavage and release of amphiregulin (AR) by TACE. GeneRIF 6868

Endres K., Anders A., Kojro E., Gilbert S., Fahrenholz F., Postina R.

Eur. J. Biochem. 270:2386-2393(2003) GeneRIF 6868 · Mapped (8)
Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation GeneRIF 6868

Contin C., Pitard V., Itai T., Nagata S., Moreau J.F., Dechanet-Merville J.

J. Biol. Chem. 278:32801-32809(2003) GeneRIF 6868 · Mapped (11)
TACE processes CD40 GeneRIF 6868

Matthews V., Schuster B., Schutze S., Bussmeyer I., Ludwig A., Hundhausen C., Sadowski T., Saftig P., Hartmann D., Kallen K.J. et al.

J. Biol. Chem. 278:38829-38839(2003) GeneRIF 6868 · Mapped (13)
cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 GeneRIF 6868

Le Gall S.M., Auger R., Dreux C., Mauduit P.

J. Biol. Chem. 278:45255-45268(2003) GeneRIF 6868 · Mapped (8)
TACE (ADAM 17) may not be the ectoprotease involved in the secretion of pro-EGF ectodomain GeneRIF 6868

Shao M.X., Ueki I.F., Nadel J.A.

Proc. Natl. Acad. Sci. U.S.A. 100:11618-11623(2003) GeneRIF 6868 · Mapped (8)
role in mucin production by airway epithelial cells by means of a TACE ligand-epidermal growth factor receptor cascade in response to various stimuli GeneRIF 6868

Karan D., Lin F.C., Bryan M., Ringel J., Moniaux N., Lin M.F., Batra S.K.

Int. J. Oncol. 23:1365-1371(2003) GeneRIF 6868 · Mapped (12)
ADAM-17/TACE and TIMP-3 might play an important role in the pathogenesis of prostate cancer GeneRIF 6868

Cruz A.C., Frank B.T., Edwards S.T., Dazin P.F., Peschon J.J., Fang K.C.

J. Biol. Chem. 279:5612-5620(2004) GeneRIF 6868 · Mapped (32)
TACE controls mast cell survival by regulating shedding and surface expression of c-Kit GeneRIF 6868

Bax D.V., Messent A.J., Tart J., van Hoang M., Kott J., Maciewicz R.A., Humphries M.J.

J. Biol. Chem. 279:22377-22386(2004) GeneRIF 6868 · Mapped (19)
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells GeneRIF 6868

Valeva A., Walev I., Weis S., Boukhallouk F., Wassenaar T.M., Endres K., Fahrenholz F., Bhakdi S., Zitzer A.

J. Biol. Chem. 279:25143-25148(2004) GeneRIF 6868 · Mapped (8)
ADAM-17 IS a potent activator of Vibrio Cholerae pro-cytolysin. GeneRIF 6868

Solomon A., Rosenblum G., Gonzales P.E., Leonard J.D., Mobashery S., Milla M.E., Sagi I.

J. Biol. Chem. 279:31646-31654(2004) GeneRIF 6868 · Mapped (10)
although there is a seemingly high structural similarity between TACE and MMP-2 these enzymes are significantly diverse in the electronic and chemical properties within their active sites GeneRIF 6868

Allinson T.M., Parkin E.T., Condon T.P., Schwager S.L., Sturrock E.D., Turner A.J., Hooper N.M.

Eur. J. Biochem. 271:2539-2547(2004) GeneRIF 6868 · Mapped (21)
ADAM10 is the major alpha-secretase cleaving amyloid precursor protein with TACE playing a minor role; neither ADAM10 nor TACE is involved in the shedding of angiotensin converting enzyme GeneRIF 6868