Ban M., Booth D., Heard R., Stewart G., Goris A., Vandenbroeck K., Dubois B., Laaksonen M., Ilonen J., Alizadeh M. et al.

J. Neuroimmunol. 179:108-116(2006) GAD 150388 GeneRIF 182 · Mapped (8)
Associated with IMMUNE: multiple sclerosis; GAD 150388 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 182

Kung A.W., Xiao S.M., Cherny S., Li G.H., Gao Y., Tso G., Lau K.S., Luk K.D., Liu J.M., Cui B. et al.

Am. J. Hum. Genet. 86:229-239(2010) GAD 600651 GeneRIF 182 · Mapped (5)
Associated with METABOLIC: Bone Mineral Density; GAD 600651 Observational study meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator); These results identify the JAG1 gene as a candidate for bone mineral density regulation in different ethnic groups and it is a potential key factor for fracture pathogenesis. GeneRIF 182

Piccoli D.A., Spinner N.B.

Semin. Liver Dis. 21:525-534(2001) GeneRIF 182 · Mapped (7)
a cell surface protein that functions in an ambryologically important signaling pathway GeneRIF 182

Jundt F., Anagnostopoulos I., Forster R., Mathas S., Stein H., Dorken B.

Blood 99:3398-3403(2002) GeneRIF 182 · Mapped (8)
interaction with Notch1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro GeneRIF 182

Masuya M., Katayama N., Hoshino N., Nishikawa H., Sakano S., Araki H., Mitani H., Suzuki H., Miyashita H., Kobayashi K. et al.

Int. J. Hematol. 75:269-276(2002) GeneRIF 182 · Mapped (5)
inhibits proliferation of cd34+ macrophage progenitors GeneRIF 182

John G.R., Shankar S.L., Shafit-Zagardo B., Massimi A., Lee S.C., Raine C.S., Brosnan C.F.

Nat. Med. 8:1115-1121(2002) GeneRIF 182 · Mapped (8)
experiments in vitro showed that Jagged1 signaling inhibited process outgrowth from primary human oligodendrocytes GeneRIF 182

Weijzen S., Velders M.P., Elmishad A.G., Bacon P.E., Panella J.R., Nickoloff B.J., Miele L., Kast W.M.

J. Immunol. 169:4273-4278(2002) GeneRIF 182 · Mapped (8)
Activation of Notch-1 signaling by Jagged-1 induces monocyte-derived dendritic cell maturation in vitro. GeneRIF 182

McElhinney D.B., Krantz I.D., Bason L., Piccoli D.A., Emerick K.M., Spinner N.B., Goldmuntz E.

Circulation 106:2567-2574(2002) GeneRIF 182 GAD 129212 · Mapped (5)
Associated with CHEMDEPENDENCY: Alagille syndrome; GAD 129212 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 182

Ascano J.M., Beverly L.J., Capobianco A.J.

J. Biol. Chem. 278:8771-8779(2003) GeneRIF 182 · Mapped (5)
identification of C-terminal PDZ-ligand is essential for cellular transformation GeneRIF 182

Tohda S., Murata-Ohsawa M., Sakano S., Nara N.

Int. J. Oncol. 22:1073-1079(2003) GeneRIF 182 · Mapped (8)
suppresses the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines GeneRIF 182

LaVoie M.J., Selkoe D.J.

J. Biol. Chem. 278:34427-34437(2003) GeneRIF 182 · Mapped (6)
Delta and Jagged undergo ADAM-mediated ectodomain processing followed by PS-mediated intramembrane proteolysis to release signaling fragments GeneRIF 182

Yvon E.S., Vigouroux S., Rousseau R.F., Biagi E., Amrolia P., Dotti G., Wagner H.J., Brenner M.K.

Blood 102:3815-3821(2003) GeneRIF 182 · Mapped (5)
Notch activation by JAG1 in the presence of alloantigen-presenting cells may therefore be a means of inducing specific regulatory T cells while preserving other T-cell functionality GeneRIF 182

Jundt F., Probsting K.S., Anagnostopoulos I., Muehlinghaus G., Chatterjee M., Mathas S., Bargou R.C., Manz R., Stein H., Dorken B.

Blood 103:3511-3515(2004) GeneRIF 182 · Mapped (17)
Notch receptors 1&2 and their ligand Jagged1 are highly expressed in cultured and primary MM cells suggesting Notch signaling is involved in the tight interactions between neoplastic plasma cells and their bone marrow microenvironment GeneRIF 182

Trifonova R., Small D., Kacer D., Kovalenko D., Kolev V., Mandinova A., Soldi R., Liaw L., Prudovsky I., Maciag T.

J. Biol. Chem. 279:13285-13288(2004) GeneRIF 182 · Mapped (6)
induced an attenuation of cell motility which is accompanied by a decrease in actin stress fibers and an increase in adherence junctions and induces a NIH 3T3 cell tranformed phenotype mediated by FGF signaling. GeneRIF 182

Murata-Ohsawa M., Tohda S., Nara N.

Int. J. Mol. Med. 14:223-226(2004) GeneRIF 182 · Mapped (6)
Delta-1 and Jagged-1 have roles in growth suppression in two myeloid leukemia cell lines GeneRIF 182

Aho S.

J. Cell. Biochem. 92:1271-1281(2004) GeneRIF 182 · Mapped (5)
soluble form of Jagged1 when present in the cell culture medium was sufficient to induce keratinocyte differentiation GeneRIF 182

Veeraraghavalu K., Pett M., Kumar R.V., Nair P., Rangarajan A., Stanley M.A., Krishna S.

J. Virol. 78:8687-8700(2004) GeneRIF 182 · Mapped (15)
upregulated in Papillomavirus-mediated cervical neoplasia and required for notch activation. GeneRIF 182

Guarnaccia C., Pintar A., Pongor S.

FEBS Lett. 574:156-160(2004) GeneRIF 182 · Mapped (5)
structured in solution as suggested by circular dichroism and NMR spectroscopy and displays an EGF-like disulfide bond topology as determined by disulfide mapping GeneRIF 182

Santagata S., Demichelis F., Riva A., Varambally S., Hofer M.D., Kutok J.L., Kim R., Tang J., Montie J.E., Chinnaiyan A.M. et al.

Cancer Res. 64:6854-6857(2004) GeneRIF 182 · Mapped (5)
Dysregulation of JAGGED1 protein levels plays a role in prostate cancer progression and metastasis and suggest that JAGGED1 may be a useful marker in distinguishing indolent and aggressive prostate cancers. GeneRIF 182

Purow B.W., Haque R.M., Noel M.W., Su Q., Burdick M.J., Lee J., Sundaresan T., Pastorino S., Park J.K., Mikolaenko I. et al.

Cancer Res. 65:2353-2363(2005) GeneRIF 182 · Mapped (9)
Down-regulation of Notch-1 Delta-like-1 or Jagged-1 by RNA interference induces apoptosis and inhibits proliferation in multiple glioma cell lines. GeneRIF 182

Kuure S., Sainio K., Vuolteenaho R., Ilves M., Wartiovaara K., Immonen T., Kvist J., Vainio S., Sariola H.

Mech. Dev. 122:765-780(2005) GeneRIF 182 · Mapped (36)
Jagged1 and GDNF/Ret/GFRalpha1 interact and have a role in regulating ureteric budding and branching GeneRIF 182

Veeraraghavalu K., Subbaiah V.K., Srivastava S., Chakrabarti O., Syal R., Krishna S.

J. Virol. 79:7889-7898(2005) GeneRIF 182 · Mapped (5)
observed that Jagged1 is preferentially upregulated in human cervical tumors and sustains tumor progression by HPV 16 oncogenes GeneRIF 182

Harendza S., Hubner C.A., Glaser C., Burdelski M., Thaiss F., Hansmann I., Gal A., Stahl R.A.

J. Nephrol. 18:312-317(2005) GeneRIF 182 · Mapped (5)
Identification of novel Jagged1 mutations in patients with Alagille syndrome. GeneRIF 182

Yuan Z.R., Kobayashi N., Kohsaka T.

J. Mol. Biol. 356:559-568(2006) GeneRIF 182 · Mapped (10)
Wild-type JAG1 is inhibitory for hepatocyte growth factor gene expression; mutant JAG1 reverses the inhibition GeneRIF 182

Beverly L.J., Ascano J.M., Capobianco A.J.

Genes Immun. 7:476-486(2006) GeneRIF 182 · Mapped (5)
data indicate a role for JAGGED/Notch signaling in the process of thymic involution GeneRIF 182