Hettema J.M., An S.S., Neale M.C., van den Oord E.J., Kendler K.S., Chen X.

Psychiatr. Genet. 18:73-79(2008) GAD 556147 GeneRIF 41 · Mapped (3)
A case-control twin study could not detect association of ACCN2 with genetic risk shared among human anxiety spectrum disorders; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 41 Not Associated with UNKNOWN: Diseases in Twins; GAD 556147

Ramagopalan S.V., Deluca G.C., Morrison K.M., Herrera B.M., Dyment D.A., Lincoln M.R., Orton S.M., Chao M.J., Degenhardt A., Pugliatti M. et al.

J. Neurol. 255:1215-1219(2008) GAD 556146 · Mapped (206)
Not Associated with IMMUNE: Multiple Sclerosis; GAD 556146

Ji H.L., Jovov B., Fu J., Bishop L.R., Mebane H.C., Fuller C.M., Stanton B.A., Benos D.J.

J. Biol. Chem. 277:8395-8405(2002) GeneRIF 41 · Mapped (48)
wild type CFTR elevates the acid-gated Na(+) current of ASIC1a/2a in part by altering the kinetics of extracellular Na(+) interaction. GeneRIF 41

Ugawa S., Ueda T., Ishida Y., Nishigaki M., Shibata Y., Shimada S.

J. Clin. Invest. 110:1185-1190(2002) GeneRIF 41 · Mapped (10)
ASICs are leading acid sensors in human nociceptors and VR1 participates in the nociception mainly under extremely acidic conditions. GeneRIF 41

Wemmie J.A., Coryell M.W., Askwith C.C., Lamani E., Leonard A.S., Sigmund C.D., Welsh M.J.

Proc. Natl. Acad. Sci. U.S.A. 101:3621-3626(2004) GeneRIF 41 · Mapped (3)
ASIC1a and H(+)-gated currents may contribute to the development of abnormal fear and to anxiety disorders. GeneRIF 41

Jones N.G., Slater R., Cadiou H., McNaughton P., McMahon S.B.

J. Neurosci. 24:10974-10979(2004) GeneRIF 41 · Mapped (11)
Ibuprofen studies show ASIC1a is a significant contributor to cutaneous acid-induced pain. GeneRIF 41

Gitterman D.P., Wilson J., Randall A.D.

J. Physiol. (Lond.) 562:759-769(2005) GeneRIF 41 · Mapped (3)
These observations strongly suggest the acid-induced current is mediated by ASIC1 channels. GeneRIF 41

Ugawa S., Ueda T., Yamamura H., Nagao M., Shimada S.

Chem. Senses 30 Suppl 1:i195-i195(2005) GeneRIF 41 · Mapped (10)
expression of vanilloid receptor subtype-1 and acid-sensing ion channel genes in the human trigeminal ganglion neurons GeneRIF 41

Shen L., Tang J.G., Tang B.S., Jiang H., Zhao G.H., Xia K., Zhang Y.H., Cai F., Tan L.M., Pan Q.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:242-247(2005) GeneRIF 41 · Mapped (6)
Data found ACCN2 interact with ataxin-3 and provide new clues for the pathogenesis of spinocerebellar ataxia type 3 and Machado-Joseph disease (SCA3/MJD). GeneRIF 41

Ye J.H., Gao J., Wu Y.N., Hu Y.J., Zhang C.P., Xu T.L.

Biochem. Biophys. Res. Commun. 355:986-992(2007) GeneRIF 41 · Mapped (3)
functional expression of ASICs is characteristic feature of adenoid cystic carcinomas cells GeneRIF 41

Cho J.H., Askwith C.C.

Am. J. Physiol., Cell Physiol. 292:C2161-74(2007) GeneRIF 41 · Mapped (3)
Sulfhydryl compounds potentiate H(+)-gated currents via two mechanisms metal chelation and redox modulation of target amino acids. GeneRIF 41

Lalo U., Pankratov Y., North R.A., Verkhratsky A.

J. Cell. Physiol. 212:473-480(2007) GeneRIF 41 · Mapped (3)
Spontaneous currents represent activation of acid-sensitive ion channels (ASICs) by autocrine vesicular release of protons from HEK cells. GeneRIF 41

Chai S., Li M., Lan J., Xiong Z.G., Saugstad J.A., Simon R.P.

J. Biol. Chem. 282:22668-22677(2007) GeneRIF 41 · Mapped (16)
AKAP150 and the protein phosphatase calcineurin are binding proteins to ASIC2a and calcineurin regulates ASIC1a and ASIC2a activity GeneRIF 41

Sherwood T.W., Askwith C.C.

J. Biol. Chem. 283:1818-1830(2008) GeneRIF 41 · Mapped (6)
endogenous peptides shift steady-state desensitization suggests that RF-amides could impact the role of ASIC1a in both pain and neuronal damage following stroke and ischemia. GeneRIF 41

Carnally S.M., Dev H.S., Stewart A.P., Barrera N.P., Van Bemmelen M.X., Schild L., Henderson R.M., Edwardson J.M.

Biochem. Biophys. Res. Commun. 372:752-755(2008) GeneRIF 41 · Mapped (3)
Atomic force microscopy was used to image unprocessed ASIC1a bound to mica. GeneRIF 41

Donier E., Rugiero F., Jacob C., Wood J.N.

Eur. J. Neurosci. 28:74-86(2008) GeneRIF 41 · Mapped (3)
Data show that transfected ASIC4 is targeted to the plasma membrane in CHO-K1 cells where it associates with ASIC1a and downregulates exogenous ASIC1a expression. GeneRIF 41

Samways D.S., Harkins A.B., Egan T.M.

Cell Calcium 45:319-325(2009) GeneRIF 41 · Mapped (3)
Patch-clamp photometry was used to determine the contribution of Ca(2+) to total current through native and recombinant ASIC1a receptors. GeneRIF 41

Kapoor N., Bartoszewski R., Qadri Y.J., Bebok Z., Bubien J.K., Fuller C.M., Benos D.J.

J. Biol. Chem. 284:24526-24541(2009) GeneRIF 41 · Mapped (14)
a significant inhibition of D54-MG cell migration after ASIC1 alphaENaC or gammaENaC knockdown consistent with the hypothesis that ENaC/Degenerin subunits play an important role in glioma cell biology. GeneRIF 41

Sherwood T., Franke R., Conneely S., Joyner J., Arumugan P., Askwith C.

J. Biol. Chem. 284:27899-27907(2009) GeneRIF 41 · Mapped (3)
Results indicate that specific regions play overlapping roles in pH-dependent gating and PcTx1-dependent modulation of ASIC1a activity whereas a distinct region determines the calcium dependence of ASIC1a activation. GeneRIF 41

Qadri Y.J., Song Y., Fuller C.M., Benos D.J.

J. Biol. Chem. 285:9627-9635(2010) GeneRIF 41 · Mapped (3)
analysis of amiloride docking to acid-sensing ion channel-1 GeneRIF 41

Bargeton B., Kellenberger S.

J. Biol. Chem. 285:13816-13826(2010) GeneRIF 41 · Mapped (3)
The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function. GeneRIF 41

Li M., Inoue K., Branigan D., Kratzer E., Hansen J.C., Chen J.W., Simon R.P., Xiong Z.G.

J. Cereb. Blood Flow Metab. 30:1247-1260(2010) GeneRIF 41 · Mapped (3)
functional homomeric ASIC1a channels are predominantly expressed in neurons from the human brain. GeneRIF 41

Liechti L.A., Berneche S., Bargeton B., Iwaszkiewicz J., Roy S., Michielin O., Kellenberger S.

J. Biol. Chem. 285:16315-16329(2010) GeneRIF 41 · Mapped (3)
A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a. GeneRIF 41

Calavia M.G., Montano J.A., Garcia-Suarez O., Feito J., Guervos M.A., Germana A., Del Valle M., Perez-Pinera P., Cobo J., Vega J.A.

Cell. Mol. Neurobiol. 30:841-848(2010) GeneRIF 41 · Mapped (7)
These results demonstrate for the first time the differential distribution of ASIC1 and ASIC2 in human rapidly adapting low-threshold mechanoreceptors and suggest specific roles of both proteins in mechanotransduction. GeneRIF 41

Carnally S.M., Johannessen M., Henderson R.M., Jackson M.B., Edwardson J.M.

Biophys. J. 98:1182-1191(2010) GeneRIF 41 · Mapped (3)
analysis of a complex between the sigma-1 receptor and a target ion channel analysis of the stoichiometry of the interaction as 1 sigma-1 receptor/1 ASIC1a subunit GeneRIF 41