Ives J.H., Drewery D.L., Thompson C.L.

J. Neurochem. 80:317-327(2002) GeneRIF 14394 · Mapped (12)
Differential cell surface expression of GABAA receptor alpha1 alpha6 beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling. GeneRIF 14394

Blednov Y.A., Jung S., Alva H., Wallace D., Rosahl T., Whiting P.J., Harris R.A.

J. Pharmacol. Exp. Ther. 304:30-36(2003) GeneRIF 14394 MGI 95613 · Mapped (10)
deletion of the alpha1 subunit of GABAA receptors reduces actions of alcohol and other drugs GeneRIF 14394

Kralic J.E., Wheeler M., Renzi K., Ferguson C., O'Buckley T.K., Grobin A.C., Morrow A.L., Homanics G.E.

J. Pharmacol. Exp. Ther. 305:600-607(2003) GeneRIF 14394 MGI 95613 · Mapped (5)
GABA(A) receptor alpha1 subunit-containing receptors appear to influence the motor-stimulating effect of ethanol and the sedative/hypnotic effects of some anesthetics GeneRIF 14394

Herring D., Huang R., Singh M., Robinson L.C., Dillon G.H., Leidenheimer N.J.

J. Biol. Chem. 278:24046-24052(2003) GeneRIF 14394 · Mapped (3)
In mouse brain cerebral cortical neurons the dileucine motif peptide increases GABA-gated chloride currents of native GABA(A) receptors. GeneRIF 14394

Chan C.H., Yeh H.H.

J. Physiol. (Lond.) 550:103-111(2003) GeneRIF 14394 · Mapped (3)
Synergistic interaction whereby activation of NMDA receptors leads to enhanced GABAA receptor-mediated activity through a Ca2+-dependent mechanism. GeneRIF 14394

Fagiolini M., Fritschy J.M., Low K., Mohler H., Rudolph U., Hensch T.K.

Science 303:1681-1683(2004) GeneRIF 14394 MGI 95613 · Mapped (10)
only alpha1 GABAA receptor-containing circuits were found to drive visual cortical plasticity GeneRIF 14394

Caldji C., Diorio J., Anisman H., Meaney M.J.

Neuropsychopharmacology 29:1344-1352(2004) GeneRIF 14394 · Mapped (3)
The srain differences in the BZ/GABAA receptor system occur at least in part as a function of parental care. Such findings may reflect a mammalian example of an indirect genetic effect mediated by maternal care. GeneRIF 14394

Bailey S.J., Toth M.

J. Neurosci. 24:6343-6351(2004) GeneRIF 14394 · Mapped (5)
The 5-HT1AR-mediated regulation of GABA(A)R alpha subunit expression is subject to genetic modification which operates early in postnatal life to influence the expression of GABA(A)R alpha subunits at the transcriptional level. GeneRIF 14394

Muller E., Triller A., Legendre P.

Eur. J. Neurosci. 20:3286-3300(2004) GeneRIF 14394 · Mapped (7)
A developmental sequence of postsynaptic events is proposed in which diffuse extrasynaptic Gabra1 subunits accumulate at inhibitory synapses to form postsynaptic clusters mostly colocalizing with glycine receptor clusters in the adult. GeneRIF 14394

Bosman L.W., Heinen K., Spijker S., Brussaard A.B.

J. Neurophysiol. 94:338-346(2005) GeneRIF 14394 MGI 95613 · Mapped (5)
This paper shows that the alpha1 -/- mice do not show a large reduction in GABAergic synapses but do retain long-lasting postsynaptic currents into adulthood. GeneRIF 14394

Stephens D.N., Pistovcakova J., Worthing L., Atack J.R., Dawson G.R.

Eur. J. Pharmacol. 526:240-250(2005) GeneRIF 14394 · Mapped (5)
Although inverse agonists acting at alpha5-containing receptors reduce ethanol self-administration alpha5 subunits may not be essential to signaling ethanol reward. GeneRIF 14394

Ogris W., Lehner R., Fuchs K., Furtmuller B., Hoger H., Homanics G.E., Sieghart W.

J. Neurochem. 96:136-147(2006) GeneRIF 14394 MGI 95613 · Mapped (5)
our results do not support a significant compensatory synthesis of other GABAA receptor subunits in the cerebellum of alpha1 -/- mice GeneRIF 14394

Vaknin U.A., Hann S.R.

J. Cell. Biochem. 97:1094-1103(2006) GeneRIF 14394 · Mapped (3)
Derepression of GABAAR-alpha1 expression upon downregulation of c-myc represents a unique apoptotic mechanism and a distinct function for the alpha1 subunit independent of its role as a component of the GABAAR in the plasma membrane. GeneRIF 14394

Fritschy J.M., Panzanelli P., Kralic J.E., Vogt K.E., Sassoe-Pognetto M.

J. Neurosci. 26:3245-3255(2006) GeneRIF 14394 MGI 95613 · Mapped (5)
Whole-cell patch-clamp recordings in acute slices revealed that PCs from alpha1(0/0) mice lack spontaneous and evoked IPSCs demonstrating that assembly of functional GABAA receptors requires the alpha1 subunit. GeneRIF 14394

Hales T.G., Deeb T.Z., Tang H., Bollan K.A., King D.P., Johnson S.J., Connolly C.N.

J. Biol. Chem. 281:17034-17043(2006) GeneRIF 14394 MGI 95613 · Mapped (17)
a conserved lysine in the TM2-3 of alpha1 beta2 and gamma2 of the GABA-A receptor has an asymmetric function in different GABAA subunits GeneRIF 14394

Skvorak K., Vissel B., Homanics G.E.

Genesis 44:345-353(2006) GeneRIF 14394 MGI 95613 · Mapped (5)
Strategy for creating GABRA1 knockin mice in which a point mutant allele replaces the wild type allele in a conditional manner e.g. in a tissue-specific and/or temporally restricted pattern. GeneRIF 14394

Ravindran C.R., Ticku M.K.

Neurochem. Res. 31:1111-1118(2006) GeneRIF 14394 · Mapped (12)
Results describe an up-regulation in the tyrosine kinase phosphorylation of GABA(A )receptor beta(2)- and gamma(2)-subunits following chronic ethanol exposure but no effect on alpha(1)-subunit in mouse cultured cortical neurons. GeneRIF 14394

Kueh S.L., Head S.I., Morley J.W.

Clin. Exp. Pharmacol. Physiol. 35:207-210(2008) GeneRIF 14394 · Mapped (3)
No difference between littermate control and mdx mice (a murine model of Duchenne muscular dystrophy) in the overall expression of the GABA(A) receptor a1-subunit at Purkinje cell synapses. GeneRIF 14394

Tyagi N., Moshal K.S., Tyagi S.C., Lominadze D.

Endothelium 14:315-323(2007) GeneRIF 14394 · Mapped (3)
The data suggest that homocysteine increases endothelial cell layer permeability through inhibition of GABA(A) receptor and F-actin formation in part by transducing ERK and MMP-9 activation. GeneRIF 14394

Picard N., Guenin S., Perrin Y., Hilaire G., Larnicol N.

Adv. Exp. Med. Biol. 605:144-148(2008) GeneRIF 14394 · Mapped (3)
Prenatal exposure to diazepam alters both normal breathing and respiratory response to hypoxia by affecting gene expression of Gabra1. GeneRIF 14394

Patrizi A., Scelfo B., Viltono L., Briatore F., Fukaya M., Watanabe M., Strata P., Varoqueaux F., Brose N., Fritschy J.M. et al.

Proc. Natl. Acad. Sci. U.S.A. 105:13151-13156(2008) GeneRIF 14394 MGI 95613 · Mapped (8)
GABA(A) receptors are dispensable for synapse formation and maintenance and for targeting NL2 to inhibitory synapses. GeneRIF 14394

Carunchio I., Mollinari C., Pieri M., Merlo D., Zona C.

Eur. J. Neurosci. 28:1275-1285(2008) GeneRIF 14394 · Mapped (3)
These data show that the functionality and expression of GABA(A) receptors are altered in G93A motor neurons inducing a higher Cl(-) influx into the cell with a possible consequent neuronal excitotoxicity acceleration. GeneRIF 14394

Kanbara K., Okamoto K., Nomura S., Kaneko T., Watanabe M., Otsuki Y.

Histol. Histopathol. 25:1229-1238(2010) GeneRIF 14394 · Mapped (3)
Report gabra1 immunoreactivity located in the nucleus of spermatogonia spermatocytes and round spermatids in mouse testes. GeneRIF 14394

Abramian A.M., Comenencia-Ortiz E., Vithlani M., Tretter E.V., Sieghart W., Davies P.A., Moss S.J.

J. Biol. Chem. 285:41795-41805(2010) GeneRIF 14394 · Mapped (11)
PKC-dependent phosphorylation of the alpha4 subunit plays a significant role in enhancing the cell surface stability and activity of GABA(A)R subtypes that mediate tonic inhibition GeneRIF 14394

Harris R.A., Osterndorff-Kahanek E., Ponomarev I., Homanics G.E., Blednov Y.A.

Neurosci. Lett. 488:31-35(2011) GeneRIF 14394 MGI 95613 · Mapped (5)
Arc and Fos increased about 50% in the alpha1 mutants. Behavioral effects (loss of righting reflex rotarod) of flurazepam and pentobarbital were not different between alpha2 mutants and wild-type but they were enhanced for alpha1 knock-in mice. GeneRIF 14394