Garami A., Zwartkruis F.J., Nobukuni T., Joaquin M., Roccio M., Stocker H., Kozma S.C., Hafen E., Bos J.L., Thomas G.

Mol. Cell 11:1457-1466(2003) GeneRIF 6194 · Mapped (11)
Rheb is a mediator of RPS6. GeneRIF 6194

Lekmine F., Sassano A., Uddin S., Smith J., Majchrzak B., Brachmann S.M., Hay N., Fish E.N., Platanias L.C.

Exp. Cell Res. 295:173-182(2004) GeneRIF 6194 · Mapped (17)
IFNgamma-activated p70 S6 kinase phosphorylates the 40S S6 ribosomal protein on serines 235/236 to regulate IFNgamma-dependent mRNA translation. GeneRIF 6194

Jansen F.E., Notenboom R.G., Nellist M., Goedbloed M.A., Halley D.J., de Graan P.N., van Nieuwenhuizen O.

Neurology 63:1293-1295(2004) GeneRIF 6194 · Mapped (5)
Cortical tuber giant cells in a case of epileptogenic tuberous sclerosis showed predominantly nuclear hamartin cytosolic tuberin and hyperphosphorylation of S6. GeneRIF 6194

Wang X.H., Fan M.W., Sun Z.J., Chen X.M., Wang L., Li Y.

Zhonghua Kou Qiang Yi Xue Za Zhi 42:140-143(2007) GeneRIF 6194 · Mapped (37)
Genetic alterations of TP53 and RPS6 were different in different areas of the same oral squamous cell carcinoma tumor. GeneRIF 6194

Gong Y., Ishida-Takahashi R., Villanueva E.C., Fingar D.C., Munzberg H., Myers M.G. Jr.

J. Biol. Chem. 282:31019-31027(2007) GeneRIF 6194 · Mapped (39)
the phosphorylation of Tyr(1077) on LepRb during receptor activation substantiate the hypothalamic regulation of STAT5 and S6 by leptin and define the alternate LepRb signaling pathways GeneRIF 6194

Nakagawa M., Ohmido N., Ishikawa K., Uchiyama S., Fukui K., Azuma T.

J. Biochem. 143:325-332(2008) GeneRIF 6194 · Mapped (5)
Structure localization and molecular assembly in vitro and in vivo of a human rpS6 were examined using antibodies (Abs) prepared by immunizing rabbits with synthetic peptides. GeneRIF 6194

Iwenofu O.H., Lackman R.D., Staddon A.P., Goodwin D.G., Haupt H.M., Brooks J.S.

Mod. Pathol. 21:231-237(2008) GeneRIF 6194 · Mapped (5)
The level of phosphorylated S6 ribosomal protein expression was predictive of early tumor response to the mammalian target of rapamycin (mTOR)inhibitor suggesting that this is a promising new predictive sarcoma marker for targeted mTOR inhibitor therapy GeneRIF 6194

Slack B.E., Blusztajn J.K.

J. Cell. Biochem. 104:1818-1831(2008) GeneRIF 6194 · Mapped (8)
The results demonstrate that multiple muscarinic receptor subtypes regulate mTOR and that both MAPK-dependent and -independent mechanisms may mediate the response in a cell context-specific manner. GeneRIF 6194

Jeon Y.J., Kim I.K., Hong S.H., Nan H., Kim H.J., Lee H.J., Masuda E.S., Meyuhas O., Oh B.H., Jung Y.K.

Oncogene 27:4344-4352(2008) GeneRIF 6194 · Mapped (11)
rpS6 especially in its unphosphorylated form is a selective mediator of TRAIL-induced apoptosis GeneRIF 6194

Glover E.I., Oates B.R., Tang J.E., Moore D.R., Tarnopolsky M.A., Phillips S.M.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 295:R604-10(2008) GeneRIF 6194 · Mapped (15)
Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men. GeneRIF 6194

Fujita K., Ito H., Nakano S., Kinoshita Y., Wate R., Kusaka H.

Acta Neuropathol. 116:439-445(2008) GeneRIF 6194 · Mapped (13)
Basophilic inclusions from patients with adult-onset atypical motor neuron disease were distinctly labeled with the antibodies against poly(A)-binding protein 1 T cell intracellular antigen 1 and ribosomal protein S6. GeneRIF 6194

Zhang X., He G.S., Wu D.P., Sun A.N., Miao M., Wang X.L., Jin Z.M., Qiu H.Y., Chang W.R.

Zhonghua Xue Ye Xue Za Zhi 30:654-657(2009) GeneRIF 6194 · Mapped (10)
The mTOR/S6 signal pathway is activated in refractory/relapsed aplastic anemia and can be suppressed by rapamycin or CTLA-4Ig. GeneRIF 6194

Terzis G., Spengos K., Mascher H., Georgiadis G., Manta P., Blomstrand E.

Eur. J. Appl. Physiol. 110:835-843(2010) GeneRIF 6194 · Mapped (13)
when exercise is performed in a fasted state the increase in phosphorylation of signalling molecules such as p70(S6k) and the S6 ribosomal protein in human muscle depends on the exercise volume GeneRIF 6194

Rosner M., Fuchs C., Dolznig H., Hengstschlager M.

Amino Acids 40:595-600(2011) GeneRIF 6194 · Mapped (5)
S240/244-phosphorylated S6 is predominantly nuclear but detectable in the cytoplasm whereas S235/236-phosphorylated S6 is exclusively localized to the nucleus. GeneRIF 6194

Chen W., Drakos E., Grammatikakis I., Schlette E.J., Li J., Leventaki V., Staikou-Drakopoulou E., Patsouris E., Panayiotidis P., Medeiros L.J. et al.

Mol. Cancer 9:292-292(2010) GeneRIF 6194 · UniProtKB (1) · Mapped (15)
Data show that the mTOR effectors 4EBP1 p70S6K and rpS6 are highly activated in cultured and primary FLT3-mutated acute myeloid leukemia (AML) cells. GeneRIF 6194

Hagner P.R., Mazan-Mamczarz K., Dai B., Balzer E.M., Corl S., Martin S.S., Zhao X.F., Gartenhaus R.B.

Oncogene 30:1531-1541(2011) GeneRIF 6194 · Mapped (5)
RPS6 associates with multiple mRNAs containing a 5' terminal oligopyrimidine tract. These findings expand our understanding of the mechanism(s) involved in ribosomal biogenesis and deregulated protein synthesis in diffuse large B-cell lymphoma (DLBCL). GeneRIF 6194

Calvisi D.F., Wang C., Ho C., Ladu S., Lee S.A., Mattu S., Destefanis G., Delogu S., Zimmermann A., Ericsson J. et al.

Gastroenterology 140:1071-1083(2011) GeneRIF 6194 · Mapped (5)
Increased lipogenesis induced by AKT-mTORC1-RPS6 signaling promotes development of human hepatocellular carcinoma. GeneRIF 6194

Hutchinson J.A., Shanware N.P., Chang H., Tibbetts R.S.

J. Biol. Chem. 286:8688-8696(2011) GeneRIF 6194 · Mapped (5)
Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. GeneRIF 6194

Chen W., Dittmer D.P.

J. Virol. 85:9495-9505(2011) GeneRIF 6194 · Mapped (5)
Here the authors show that ribosomal protein S6 (RPS6) interacts with LANA. GeneRIF 6194

Hasgall P.A., Hoogewijs D., Faza M.B., Panse V.G., Wenger R.H., Camenisch G.

PLoS ONE 6:e22107-e22107(2011) GeneRIF 6194 · Mapped (9)
Downregulation of HELZ reduced translational initiation resulting in the disassembly of polysomes in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6. GeneRIF 6194

Hager M., Haufe H., Alinger B., Kolbitsch C.

Pathol. Oncol. Res. 18:277-283(2012) GeneRIF 6194 · Mapped (5)
High Ribosomal Protein S6 is associated with renal cell carcinoma metastases. GeneRIF 6194

Castellani R.J., Gupta Y., Sheng B., Siedlak S.L., Harris P.L., Coller J.M., Perry G., Lee H.G., Tabaton M., Smith M.A. et al.

Lab. Invest. 91:1777-1786(2011) GeneRIF 6194 · Mapped (5)
Nearly 20-fold more neurons contain pS6-positive granules in Alzheimer's disease hippocampus compared to age-matched controls. GeneRIF 6194

Li Y., Mitsuhashi S., Ikejo M., Miura N., Kawamura T., Hamakubo T., Ubukata M.

Biosci. Biotechnol. Biochem. 76:486-494(2012) GeneRIF 6194 · Mapped (5)
a novel mechanism for modulating the RPS6 function by PP1 and ATM which regulates cell growth and survival in response to DNA-damage stim GeneRIF 6194

Peterson D.T., Merrick W.C., Safer B.

J. Biol. Chem. 254:2509-2516(1979) Reactome REACT_71 Reactome REACT_17015 · Mapped (55)

Benne R., Hershey J.W.B.

J. Biol. Chem. 253:3078-3087(1978) Reactome REACT_17015 Reactome REACT_71 · UniProtKB (2) · Mapped (55)