| Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Breitenlechner C., Gassel M., Hidaka H., Kinzel V., Huber R., Engh R.A., Bossemeyer D.
Structure 11:1595-1607(2003) PDB 2GNI PDB 1Q8T · Mapped (6) |
| Structure-based optimization of novel azepane derivatives as PKB inhibitors. Breitenlechner C.B., Wegge T., Berillon L., Graul K., Marzenell K., Friebe W.G., Thomas U., Schumacher R., Huber R., Engh R.A. et al.
J. Med. Chem. 47:1375-1390(2004) PDB 1VEB PDB 1XHA PDB 1XH4 PDB 1XH5 PDB 1XH6 PDB 1XH7 PDB 1XH8 PDB 1XH9 · Mapped (4) |
| Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants. Breitenlechner C.B., Friebe W.G., Brunet E., Werner G., Graul K., Thomas U., Kunkele K.P., Schafer W., Gassel M., Bossemeyer D. et al.
J. Med. Chem. 48:163-170(2005) PDB 1XH4 PDB 1XH8 PDB 1XH7 PDB 1XH6 PDB 1XHA PDB 1XH9 PDB 1XH5 · Mapped (2) |
| Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B. Collins I., Caldwell J., Fonseca T., Donald A., Bavetsias V., Hunter L.J., Garrett M.D., Rowlands M.G., Aherne G.W., Davies T.G. et al.
Bioorg. Med. Chem. 14:1255-1273(2006) PDB 2C1B PDB 2C1A · Mapped (1) |
| Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Li Q., Woods K.W., Thomas S., Zhu G.D., Packard G., Fisher J., Li T., Gong J., Dinges J., Song X. et al.
Bioorg. Med. Chem. Lett. 16:2000-2007(2006) PDB 2F7E · Mapped (2) |
| Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity. Bonn S., Herrero S., Breitenlechner C.B., Erlbruch A., Lehmann W., Engh R.A., Gassel M., Bossemeyer D.
J. Biol. Chem. 281:24818-24830(2006) PDB 2GNI · Mapped (4) |
| A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. Davies T.G., Verdonk M.L., Graham B., Saalau-Bethell S., Hamlett C.C., McHardy T., Collins I., Garrett M.D., Workman P., Woodhead S.J. et al.
J. Mol. Biol. 367:882-894(2007) PDB 2JDV PDB 2JDT PDB 2JDS · Mapped (2) |
| Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design. Donald A., McHardy T., Rowlands M.G., Hunter L.J., Davies T.G., Berdini V., Boyle R.G., Aherne G.W., Garrett M.D., Collins I.
J. Med. Chem. 50:2289-2292(2007) PDB 2UVX · Mapped (1) |
| cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Madhusudan, Trafny E.A., Xuong N.H., Adams J.A., Ten Eyck L.F., Taylor S.S., Sowadski J.M.
Protein Sci. 3:176-187(1994) PDB 1JLU · Mapped (3) |
| Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Zheng J., Knighton D.R., Xuong N.H., Taylor S.S., Sowadski J.M., Ten Eyck L.F.
Protein Sci. 2:1559-1573(1993) PDB 1CMK · Mapped (2) |
| Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. Engh R.A., Girod A., Kinzel V., Huber R., Bossemeyer D.
J. Biol. Chem. 271:26157-26164(1996) PDB 1YDR · UniProtKB (1) · Mapped (2) |
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