MacLachlan T.K., El-Deiry W.S.

Proc. Natl. Acad. Sci. U.S.A. 99:9492-9497(2002) GeneRIF 839 · Mapped (33)
identified executioner caspase-6 as a transcriptional target of p53. The mechanism involves DNA binding by p53 to the third intron of the caspase-6 gene and transactivation. GeneRIF 839

Sordet O., Rebe C., Dubrez-Daloz L., Boudard D., Solary E.

Leukemia 16:1569-1570(2002) GeneRIF 839 · Mapped (18)
Pro-CASP6 was the only proenzyme whose localization was limited to the cytosol in U937 cells during TPA-induced differentiation. GeneRIF 839

Mendez E., Salas-Ocampo E., Arias C.F.

J. Virol. 78:8601-8608(2004) GeneRIF 839 · UniProtKB (1) · Mapped (3)
induced and utilized by human Astrovirus Yuc8 to promote processing of the capsid precursor and dissemination of the viral particles in CAC0-2 cells. GeneRIF 839

Schmeck B., Gross R., N'Guessan P.D., Hocke A.C., Hammerschmidt S., Mitchell T.J., Rosseau S., Suttorp N., Hippenstiel S.

Infect. Immun. 72:4940-4947(2004) GeneRIF 839 · Mapped (1)
programmed cell death was executed by caspase 6 in Streptococcus pneumoniae infected lung epithelium GeneRIF 839

Horowitz P.M., Patterson K.R., Guillozet-Bongaarts A.L., Reynolds M.R., Carroll C.A., Weintraub S.T., Bennett D.A., Cryns V.L., Berry R.W., Binder L.I.

J. Neurosci. 24:7895-7902(2004) GeneRIF 839 · Mapped (7)
CASP-6 cleaves the N terminus of tau in vitro at D13 a semicanonical and hitherto undescribed caspase cleavage site in tau. This suggests a role for caspase-6 & N-terminal truncation of tau during neurofibrillary tangle & Alzheimer's disease progression. GeneRIF 839

Yoo N.J., Lee J.W., Kim Y.J., Soung Y.H., Kim S.Y., Nam S.W., Park W.S., Lee J.Y., Lee S.H.

APMIS 112:330-335(2004) GeneRIF 839 · Mapped (11)
caspase-2 -6 and -7 expression in gastric cancer cells is decreased compared to in normal gastric mucosal cells GeneRIF 839

Kalinin A.E., Kalinin A.E., Aho M., Uitto J., Aho S.

J. Invest. Dermatol. 124:46-55(2005) GeneRIF 839 · Mapped (3)
caspase 6 cleaves periplakin at an unconventional recognition site amino acid sequence TVAD GeneRIF 839

Guo H., Petrin D., Zhang Y., Bergeron C., Goodyer C.G., LeBlanc A.C.

Cell Death Differ. 13:285-292(2006) GeneRIF 839 · Mapped (9)
results show that Csp-1 is an upstream positive regulator of Csp-6-mediated cell death in primary human neurons; also results suggest that the activation of Csp-1 must be accompanied by an apoptotic insult to induce Csp-6-mediated cell death GeneRIF 839

Werz O., Tretiakova I., Michel A., Ulke-Lemee A., Hornig M., Franke L., Schneider G., Samuelsson B., Radmark O., Steinhilber D.

Proc. Natl. Acad. Sci. U.S.A. 102:13164-13169(2005) GeneRIF 839 · Mapped (8)
results suggest that splitting of BL41-E95-A cells induces de novo synthesis of a protein involved in the activation of casp-6 and casp-8 which cleaves 5-LO. GeneRIF 839

Lee S.C., Chan J., Clement M.V., Pervaiz S.

Proteomics 6:2386-2394(2006) GeneRIF 839 · Mapped (44)
caspase-6 and its cleavage of lamin A are critical in apoptotic signaling triggered by resveratrol in the colon carcinoma cells which can be activated in the absence of Bax or p53 GeneRIF 839

Lee J.W., Kim M.R., Soung Y.H., Nam S.W., Kim S.H., Lee J.Y., Yoo N.J., Lee S.H.

APMIS 114:646-650(2006) GeneRIF 839 · Mapped (1)
data indicate that the CASP6 gene is occasionally mutated in gastric and colorectal carcinomas; also the data suggest the possibility that deficiency of caspase-6 expression might contribute to the pathogenesis of gastric cancers GeneRIF 839

Blazquez S., Sirvent J.J., Olona M., Aguilar C., Pelegri A., Garcia J.F., Palacios J.

Histol. Histopathol. 21:1321-1329(2006) GeneRIF 839 · Mapped (3)
Caspase-6 was overexpressed in 52.9% of the 210 cases studied showing predominantly cyoplasmic with some nuclear staining. GeneRIF 839

Albrecht S., Bourdeau M., Bennett D., Mufson E.J., Bhattacharjee M., LeBlanc A.C.

Am. J. Pathol. 170:1200-1209(2007) GeneRIF 839 · Mapped (1)
Active caspase-6 could be an early instigator of neuronal dysfunction. GeneRIF 839

Diemer C., Schneider M., Seebach J., Quaas J., Frosner G., Schatzl H.M., Gilch S.

J. Mol. Biol. 376:23-34(2008) GeneRIF 839 · Mapped (5)
The experiments revealed that N induces the intrinsic apoptotic pathway resulting in processing of N at residues 400 and 403 by caspase-6 and/or caspase-3. GeneRIF 839

Chan J.Y., Phoo M.S., Clement M.V., Pervaiz S., Lee S.C.

Cancer Biol. Ther. 7:1305-1312(2008) GeneRIF 839 · Mapped (33)
Resveratrol displays converse dose-related effects on fluorouracil-evoked colon cancer cell apoptosis: the role of CASP6 is reported. GeneRIF 839

Nassiri M., Woolery-Lloyd H., Ramos S., Jacob S.E., Gugic D., Viciana A., Romanelli P., Elgart G., Berman B., Vincek V.

Arch. Dermatol. Res. 301:183-188(2009) GeneRIF 839 · Mapped (4)
Expression of caspase 6 and caspase 14 genes were different between normal skin of keloid-prone individuals and normal skin of keloid-resistant patients. GeneRIF 839

Chan Y.W., Chen Y., Poon R.Y.

Oncogene 28:170-183(2009) GeneRIF 839 · Mapped (10)
Caspase 6 cleaves cyclin B1 during mitotic catastrophe. Mitotic & apoptotic functions may be linked by caspase-dependent processing of mitotic activators. GeneRIF 839

Wai M.S., Liang Y., Shi C., Cho E.Y., Kung H.F., Yew D.T.

Biogerontology 10:457-469(2009) GeneRIF 839 · Mapped (9)
Report co-localization of hyperphosphorylated tau and caspases 3/6 in the brainstem of Alzheimer's disease patients. GeneRIF 839

Eguchi R., Tone S., Suzuki A., Fujimori Y., Nakano T., Kaji K., Ohta T.

Exp. Cell Res. 315:327-335(2009) GeneRIF 839 · Mapped (4)
During hypoxia in tube-forming endothelial cells caspase-7 is responsible for chromatin condensation and nuclear fragmentation while caspase-6 is responsible for DNA ladder formation. GeneRIF 839

Kim J.G., Sohn S.K., Chae Y.S., Song H.S., Kwon K.Y., Do Y.R., Kim M.K., Lee K.H., Hyun M.S., Lee W.S. et al.

Cancer Chemother. Pharmacol. 64:355-360(2009) GeneRIF 839 · Mapped (72)
Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 839

Kim J.G., Chae Y.S., Sohn S.K., Moon J.H., Ryoo H.M., Bae S.H., Kum Y., Jeon S.W., Lim K.H., Kang B.M. et al.

Cancer Chemother. Pharmacol. 64:953-960(2009) GeneRIF 839 · Mapped (78)
Clinical trial of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 839

Kim Y.R., Kim K.M., Yoo N.J., Lee S.H.

Hum. Pathol. 40:868-871(2009) GeneRIF 839 · Mapped (34)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 839

Lan Q., Morton L.M., Armstrong B., Hartge P., Menashe I., Zheng T., Purdue M.P., Cerhan J.R., Zhang Y., Grulich A. et al.

Blood 114:264-267(2009) GeneRIF 839 · Mapped (38)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 839

Hosgood H.D., Zhang L., Shen M., Berndt S.I., Vermeulen R., Li G., Yin S., Yeager M., Yuenger J., Rothman N. et al.

Occup Environ Med 66:848-853(2009) GeneRIF 839 GAD 564442 · Mapped (1,047)
Not Associated with PHARMACOGENOMIC: benzene haematotoxicity; GAD 564442 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 839

Carter B.Z., Mak D.H., Schober W.D., Koller E., Pinilla C., Vassilev L.T., Reed J.C., Andreeff M.

Blood 115:306-314(2010) GeneRIF 839 · Mapped (60)
p53 activation enhances XIAP inhibition-induced cell death by promoting mitochondrial release of second mitochondria-derived activator of caspases (SMAC) and by inducing the expression of caspase-6. GeneRIF 839