Harmsen A., Kusser K., Hartson L., Tighe M., Sunshine M.J., Sedgwick J.D., Choi Y., Littman D.R., Randall T.D.

J. Immunol. 168:986-990(2002) GeneRIF 19885 · Mapped (20)
The organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of retinoic acid receptor-related orphan receptor-gamma. GeneRIF 19885

He Y.W.

J. Leukoc. Biol. 72:440-446(2002) GeneRIF 19885 · Mapped (6)
Review.The orphan nuclear receptor RORgamma has been shown to promote thymocyte survival by activating the expression of antiapoptotic protein Bcl-x(L). RORgamma is also required for the development of lymph nodes and Peyer's patches. GeneRIF 19885

Broussard D.R., Lozano M.M., Dudley J.P.

J. Virol. 78:4943-4946(2004) GeneRIF 19885 · Mapped (4)
Rorgamma locus is integration site in 19% of Type B Leukemogenic virus (TBLV)-induced tumors GeneRIF 19885

Eberl G., Littman D.R.

Science 305:248-251(2004) GeneRIF 19885 MGI 104856 · Mapped (10)
intestinal intraepithelial T lymphocytes expressing the alphabeta T cell receptor are derived from precursors that express RORgammat GeneRIF 19885

Xie H., Sadim M.S., Sun Z.

J. Immunol. 175:3800-3809(2005) GeneRIF 19885 · Mapped (4)
RORgammat recruits SRCs to impose a gene expression pattern required to expand the life span of thymocytes in vivo which increases the opportunities for assembling a functional TCR. GeneRIF 19885

Raichur S., Lau P., Staels B., Muscat G.E.

J. Mol. Endocrinol. 39:29-44(2007) GeneRIF 19885 · Mapped (4)
function for RORgamma in the pathway that regulates production of reactive oxygen species in skeletal muscle GeneRIF 19885

Kang H.S., Angers M., Beak J.Y., Wu X., Gimble J.M., Wada T., Xie W., Collins J.B., Grissom S.F., Jetten A.M.

Physiol. Genomics 31:281-294(2007) GeneRIF 19885 · Mapped (4)
RORC influences the regulation of several metabolic pathways including those involved in the metabolism of steroids bile acids and xenobiotics suggesting that RORC is important in the control of metabolic homeostasis. GeneRIF 19885

Grechez-Cassiau A., Rayet B., Guillaumond F., Teboul M., Delaunay F.

J. Biol. Chem. 283:4535-4542(2008) GeneRIF 19885 · Mapped (19)
oscillation of p21WAF1/CIP1 gene transcription is regulated by the antagonistic activities of the orphan nuclear receptors REV-ERBalpha/beta and RORalpha4/gamma which are core clock regulators GeneRIF 19885

Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S. et al.

Immunity 28:29-39(2008) GeneRIF 19885 MGI 104856 · Mapped (17)
Th17 differentiation is directed by two lineage-specific nuclear receptors ROR alpha and ROR gamma. GeneRIF 19885

Ichiyama K., Yoshida H., Wakabayashi Y., Chinen T., Saeki K., Nakaya M., Takaesu G., Hori S., Yoshimura A., Kobayashi T.

J. Biol. Chem. 283:17003-17008(2008) GeneRIF 19885 MGI 104856 · Mapped (26)
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat GeneRIF 19885

Yang Y., Wang H.C., Sun X.H.

BMC Immunol. 9:20-20(2008) GeneRIF 19885 · Mapped (4)
Id1 expression diminished RORgammat mRNA levels in T cell lines and primary thymocytes GeneRIF 19885

Michel M.L., Mendes-da-Cruz D., Keller A.C., Lochner M., Schneider E., Dy M., Eberl G., Leite-de-Moraes M.C.

Proc. Natl. Acad. Sci. U.S.A. 105:19845-19850(2008) GeneRIF 19885 MGI 104856 · Mapped (5)
The transcription factor ROR-gammat is critical for the thymic differentiation of this iNKT cells subset because only ROR-gammat(pos) iNKT cells are capable of massively secreting IL-17 expression. GeneRIF 19885

Mongrain V., Ruan X., Dardente H., Fortier E.E., Cermakian N.

Genes Cells 13:1197-1210(2008) GeneRIF 19885 · Mapped (10)
provide insights into the molecular mechanisms that lead to differential expression of Rorgamma and Rorgammat and are suggestive of a framework that might account for tissue-specific circadian regulation. GeneRIF 19885

Naito T., Shiohara T., Hibi T., Suematsu M., Ishikawa H.

Mucosal Immunol 1:198-207(2008) GeneRIF 19885 · Mapped (4)
ROR gamma t-deficient mice develop the normal number of intestinal mucosal T cells. GeneRIF 19885

Huber M., Brustle A., Reinhard K., Guralnik A., Walter G., Mahiny A., von Low E., Lohoff M.

Proc. Natl. Acad. Sci. U.S.A. 105:20846-20851(2008) GeneRIF 19885 · Mapped (6)
IRF4 as a decisive factor during the IL-21-mediated steps of Th17 development by influencing the balance of Foxp3 RORalpha and RORgammat. GeneRIF 19885

Mukherjee S., Schaller M.A., Neupane R., Kunkel S.L., Lukacs N.W.

J. Immunol. 182:7381-7388(2009) GeneRIF 19885 · Mapped (5)
Dll4 up-regulates Rorc expression in T cells and that both Rorc and Il17 gene promoters are direct transcriptional notch targets that further enhance the differentiation of Th17 cell populations GeneRIF 19885

Doisne J.M., Becourt C., Amniai L., Duarte N., Le Luduec J.B., Eberl G., Benlagha K.

J. Immunol. 183:2142-2149(2009) GeneRIF 19885 · Mapped (8)
the one stable iNKT population found in peripheral lymph nodes comprises a major IL-17-producing population and expresses the retinoic acid receptor-related orphan receptor (gamma)t. GeneRIF 19885

Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.D., Stayrook K.R., Zhang X., Novick S. et al.

J. Biol. Chem. 285:5013-5025(2010) GeneRIF 19885 · Mapped (16)
RORalpha and RORgamma are ligand-regulated members of the NR superfamily and may serve as sensors for 7-oxygenated sterols. GeneRIF 19885

Cornelissen F., Mus A.M., Asmawidjaja P.S., van Hamburg J.P., Tocker J., Lubberts E.

Arthritis Res. Ther. 11:R194-R194(2009) GeneRIF 19885 · Mapped (4)
IL-23 regulates IL-17A and RORgammat expression in TCRgammadelta T cells in arthritis GeneRIF 19885

Martinez G.J., Zhang Z., Reynolds J.M., Tanaka S., Chung Y., Liu T., Robertson E., Lin X., Feng X.H., Dong C.

J. Biol. Chem. 285:29039-29043(2010) GeneRIF 19885 · Mapped (12)
Data found that Smad2 associated with retinoid acid receptor-related orphan receptor-gammat (RORgammat) and enhanced RORgammat-induced Th17 cell generation. GeneRIF 19885

Lebson L., Gocke A., Rosenzweig J., Alder J., Civin C., Calabresi P.A., Whartenby K.A.

J. Immunol. 185:7161-7164(2010) GeneRIF 19885 · Mapped (8)
KLF4-deficient T cells upregulated expression of retinoic acid-related orphan receptor gammat similar to wild-type during the polarization process toward Th17 suggesting that these two transcription factors are regulated independently. GeneRIF 19885

Sawa S., Lochner M., Satoh-Takayama N., Dulauroy S., Berard M., Kleinschek M., Cua D., Di Santo J.P., Eberl G.

Nat. Immunol. 12:320-326(2011) GeneRIF 19885 MGI 104856 · Mapped (8)
Data identify a finely tuned equilibrium among intestinal symbionts adaptive immunity and RORgammat+ ILCs. GeneRIF 19885

Sanos S.L., Vonarbourg C., Mortha A., Diefenbach A.

Immunology 132:453-465(2011) GeneRIF 19885 · Mapped (19)
Studies indicate that innate lymphocyte subset co-expressing RORgammat NK cell receptors and Il-22 has been identified. GeneRIF 19885

Codarri L., Gyulveszi G., Tosevski V., Hesske L., Fontana A., Magnenat L., Suter T., Becher B.

Nat. Immunol. 12:560-567(2011) GeneRIF 19885 · Mapped (17)
Data show that GM-CSF-secretion is dependent on RORgammat expression GeneRIF 19885

Fujisawa Y., Nabekura T., Kawachi Y., Otsuka F., Onodera M.

Asian Pac. J. Allergy Immunol. 29:86-93(2011) GeneRIF 19885 · Mapped (4)
enforced expression of ROR(gamma)t in haematopoietic stem cells induces differentiation of Thl7 cells and results in an increase in Foxp3(+) Treg cell number to limit self-tissue damage GeneRIF 19885