Liang X.S., Caporaso N., McMaster M.L., Ng D., Landgren O., Yeager M., Chanock S., Goldin L.R.

Br. J. Haematol. 146:418-423(2009) GAD 561205 GeneRIF 8743 · Mapped (533)
Associated with CANCER: chronic lymphocytic leukaemia; Waldenstrom macroglobulinaemia; GAD 561205 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 8743

Gong B., Almasan A.

Cancer Res. 60:5754-5760(2000) GeneRIF 8743 · Mapped (3)
Apo2 ligand mRNA levels increase following irradiation of human T lineage-derived tumor cells. Recombinant soluble Apo2L enhanced the lethality of therapeutic doses of irradiation indicating their possible use in combination for clinical therapy. GeneRIF 8743

Gong B., Almasan A.

Biochem. Biophys. Res. Commun. 278:747-752(2000) GeneRIF 8743 · Mapped (3)
The Apo2L gene spans ~ 20 kb and is composed of 5 exons. The 1.2-kb Apo2L promoter region upstream of the translation initiation codon was cloned its transcription start site defined and several putative transcription factor binding sites identified. GeneRIF 8743

Chou A.H., Tsai H.F., Lin L.L., Hsieh S.L., Hsu P.I., Hsu P.N.

J. Immunol. 167:1347-1352(2001) GeneRIF 8743 · Mapped (3)
TNF-related apoptosis-inducing ligand (TRAIL) enhances T cell proliferation following T cell receptor engagement and signals the augmentation of IFN-gamma secretion via a p38 mitogen-activated protein kinase-dependent pathway. GeneRIF 8743

Chen Q., Gong B., Mahmoud-Ahmed A.S., Zhou A., Hsi E.D., Hussein M., Almasan A.

Blood 98:2183-2192(2001) GeneRIF 8743 · Mapped (3)
Interferon-alpha and -beta but not -gamma induce apoptosis through Apo2 ligand transcriptional induction in multiple myeloma tumor cells and freshly derived primary cells. GeneRIF 8743

Monleon I., Martinez-Lorenzo M.J., Monteagudo L., Lasierra P., Taules M., Iturralde M., Pineiro A., Larrad L., Alava M.A., Naval J. et al.

J. Immunol. 167:6736-6744(2001) GeneRIF 8743 · Mapped (6)
Differential secretion of APO2 ligand microvesicles during activation-induced death of T cells GeneRIF 8743

Gray H.L., Sorensen E.L., Hunt J.S., Ober C.

Genes Immun. 2:469-470(2001) GeneRIF 8743 · Mapped (3)
Observational study of genotype prevalence. (HuGE Navigator) GeneRIF 8743

Silvestris F., Cafforio P., Tucci M., Dammacco F.

Blood 99:1305-1313(2002) GeneRIF 8743 · Mapped (6)
Up-regulation in highly malignant multiple myeloma plasma cells negatively regulates erythroblast maturation; a major pathogenetic mechanism of anemia in multiple myeloma. GeneRIF 8743

Dorr J., Bechmann I., Waiczies S., Aktas O., Walczak H., Krammer P.H., Nitsch R., Zipp F.

J. Neurosci. 22:RC209-RC209(2002) GeneRIF 8743 · Mapped (20)
TNF-related apoptosis-inducing ligand (TRAIL) is not constitutively expressed in the human brain whereas both apoptosis-mediating and apoptosis-blocking TRAIL receptors are found on neurons astrocytes and oligodendrocytes GeneRIF 8743

Lee M.W., Park S.C., Yang Y.G., Yim S.O., Chae H.S., Bach J.H., Lee H.J., Kim K.Y., Lee W.B., Kim S.S.

FEBS Lett. 512:313-318(2002) GeneRIF 8743 · Mapped (8)
TRAIL/Apo2L-induced apoptosis is mediated by ROS-activated p38 MAP kinase followed by caspase activation in HeLa cells. GeneRIF 8743

Mitsiades N., Mitsiades C.S., Poulaki V., Anderson K.C., Treon S.P.

Blood 99:2162-2171(2002) GeneRIF 8743 · Mapped (8)
signaling pathway and intracellular regulation of TRAIL-induced apoptosis in multiple myeloma cells GeneRIF 8743

Ruiz-Ruiz C., Lopez-Rivas A.

Biochem. J. 365:825-832(2002) GeneRIF 8743 · Mapped (15)
Results suggest that IFN-gamma facilitates TRAIL-induced activation of mitochondria-regulated as well as mitochondria-independent apoptotic pathways in breast tumour cells. GeneRIF 8743

Kim Y., Suh N., Sporn M., Reed J.C.

J. Biol. Chem. 277:22320-22329(2002) GeneRIF 8743 · Mapped (8)
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis GeneRIF 8743

Inoue H., Shiraki K., Ohmori S., Sakai T., Deguchi M., Yamanaka T., Okano H., Nakano T.

Int. J. Mol. Med. 9:521-525(2002) GeneRIF 8743 · Mapped (3)
Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. GeneRIF 8743

Guo F., Nimmanapalli R., Paranawithana S., Wittman S., Griffin D., Bali P., O'Bryan E., Fumero C., Wang H.G., Bhalla K.

Blood 99:3419-3426(2002) GeneRIF 8743 · Mapped (3)
Apo-2L-induced processing of caspase-3 caspase-8 and Bid is significantly increased by overexpression of Smac/DIABLO. GeneRIF 8743

Lunemann J.D., Waiczies S., Ehrlich S., Wendling U., Seeger B., Kamradt T., Zipp F.

J. Immunol. 168:4881-4888(2002) GeneRIF 8743 · Mapped (3)
Although it does not contribute to mechanisms of peripheral T cell tolerance such as clonal anergy or deletion by apoptosis TRAIL can directly inhibit activation of human T cells via blockade of calcium influx. GeneRIF 8743

Leaman D.W., Chawla-Sarkar M., Vyas K., Reheman M., Tamai K., Toji S., Borden E.C.

J. Biol. Chem. 277:28504-28511(2002) GeneRIF 8743 · UniProtKB (1) · Mapped (4)
XAF1 augments TRAIL-induced apoptosis GeneRIF 8743

Sarker M., Ruiz-Ruiz C., Robledo G., Lopez-Rivas A.

Oncogene 21:4323-4327(2002) GeneRIF 8743 · Mapped (3)
Stimulation of the mitogen-activated protein kinase pathway antagonizes TRAIL-induced apoptosis downstream of BID cleavage in human breast cancer MCF-7 cells. GeneRIF 8743

Kim J.Y., Kim Y.H., Chang I., Kim S., Pak Y.K., Oh B.H., Yagita H., Jung Y.K., Oh Y.J., Lee M.S.

Oncogene 21:3139-3148(2002) GeneRIF 8743 · Mapped (3)
TRAIL induced translocation of Bax after cleavage of Bid in parental cells but not mitochondrial-DNA-deficient cells. GeneRIF 8743

Dorothee G., Vergnon I., Menez J., Echchakir H., Grunenwald D., Kubin M., Chouaib S., Mami-Chouaib F.

J. Immunol. 169:809-817(2002) GeneRIF 8743 · Mapped (3)
APO2L/TRAIL specifically induced by autologous tumor and up-regulated by IFN-alpha is a key mediator of tumor-specific CD4+ cytotoxic T lymphocyte-mediated cell death. GeneRIF 8743

Chawla-Sarkar M., Leaman D.W., Jacobs B.S., Borden E.C.

J. Immunol. 169:847-855(2002) GeneRIF 8743 · Mapped (6)
TRAIL/Apo2L in combination with interferon-beta synergistically induces apoptosis and inhibits melanoma cell proliferation in vitro at least in part by cleavage of the X-linked inhibitor of apoptosis (XIAP). GeneRIF 8743

Fulda S., Wick W., Weller M., Debatin K.M.

Nat. Med. 8:808-815(2002) GeneRIF 8743 · Mapped (3)
Data show that transfer of the gene encoding Smac sensitized tumor and malignant glioma cells for apoptosis and that Smac peptides enhanced the antitumor activity of Apo-2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). GeneRIF 8743

Sprick M.R., Rieser E., Stahl H., Grosse-Wilde A., Weigand M.A., Walczak H.

EMBO J. 21:4520-4530(2002) GeneRIF 8743 Reactome REACT_578 · Mapped (12)
Caspase-10 is recruited to and activated at the native TRAIL death-inducing signalling complex in a FADD-dependent manner. GeneRIF 8743

Modur V., Nagarajan R., Evers B.M., Milbrandt J.

J. Biol. Chem. 277:47928-47937(2002) GeneRIF 8743 · Mapped (7)
TRAIL is a direct target of FKHRL1 GeneRIF 8743

Berger T., Kretzler M.

Biochem. Biophys. Res. Commun. 297:880-884(2002) GeneRIF 8743 · Mapped (5)
induces apoptosis independently of the mitochondrial apoptosis mediator DAP3 GeneRIF 8743