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The spindle midzone microtubule-associated proteins Ase1p and Cin8p affect the number and orientation of astral microtubules in Saccharomyces cerevisiae.

de Gramont A., Barbour L., Ross K.E., Cohen-Fix O.

Cell Cycle 6:1231-1241(2007) GeneRIF 854223 SGD S000005584 · Mapped (3)
Ase1p and Cin8p affect nuclear positioning through astral micro-tubule-dependent mechanisms. GeneRIF 854223 Cellular Location|Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000005584

Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.

Huang J.N., Park I., Ellingson E., Littlepage L.E., Pellman D.

J. Cell Biol. 154:85-94(2001) SGD S000005584 · UniProtKB (1) · Mapped (10)
Cell Cycle Phase Involved|Function/Process|Mutants/Phenotypes|Protein Processing/Modification/Regulation|Protein Sequence Features|RNA Levels and Processing|Regulation of|Strains/Constructs|Techniques and Reagents SGD S000005584

Systematic genetic analysis with ordered arrays of yeast deletion mutants.

Tong A.H., Evangelista M., Parsons A.B., Xu H., Bader G.D., Page N., Robinson M., Raghibizadeh S., Hogue C.W., Bussey H. et al.

Science 294:2364-2368(2001) SGD S000005584 · Mapped (203)
Genetic Interactions|Strains/Constructs SGD S000005584

The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.

Schuyler S.C., Liu J.Y., Pellman D.

J. Cell Biol. 160:517-528(2003) SGD S000005584 · Mapped (1)
Cellular Location|Function/Process|Fungal Related Genes/Proteins|Mutants/Phenotypes|Protein-protein Interactions|Strains/Constructs SGD S000005584

Targets of the cyclin-dependent kinase Cdk1.

Ubersax J.A., Woodbury E.L., Quang P.N., Paraz M., Blethrow J.D., Shah K., Shokat K.M., Morgan D.O.

Nature 425:859-864(2003) SGD S000005584 · UniProtKB (33) · Mapped (163)
Protein Processing/Modification/Regulation|Regulation of SGD S000005584

Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14.

Pereira G., Schiebel E.

Science 302:2120-2124(2003) SGD S000005584 · Mapped (5)
Cellular Location|Function/Process SGD S000005584

The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis.

Cao K., Nakajima R., Meyer H.H., Zheng Y.

Cell 115:355-367(2003) SGD S000005584 · UniProtKB (1) · Mapped (6)
Protein-protein Interactions|Regulation of|Strains/Constructs SGD S000005584

Cell division: AAAtacking the mitotic spindle.

Cheeseman I.M., Desai A.

Curr. Biol. 14:R70-2(2004) SGD S000005584 · Mapped (4)
S000005584 SGD S000005584

Global mapping of the yeast genetic interaction network.

Tong A.H., Lesage G., Bader G.D., Ding H., Xu H., Xin X., Young J., Berriz G.F., Brost R.L., Chang M. et al.

Science 303:808-813(2004) SGD S000005584 · Mapped (971)
Genetic Interactions|Strains/Constructs SGD S000005584

DBRF-MEGN method: an algorithm for deducing minimum equivalent gene networks from large-scale gene expression profiles of gene deletion mutants.

Kyoda K., Baba K., Onami S., Kitano H.

Bioinformatics 20:2662-2675(2004) SGD S000005584 · Mapped (61)
Function/Process SGD S000005584

Severing all ties between mother and daughter: cell separation in budding yeast.

Yeong F.M.

Mol. Microbiol. 55:1325-1331(2005) SGD S000005584 · Mapped (7)
Reviews SGD S000005584

Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.

Loog M., Morgan D.O.

Nature 434:104-108(2005) SGD S000005584 · Mapped (18)
Protein Processing/Modification/Regulation SGD S000005584

Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae.

Daniel J.A., Keyes B.E., Ng Y.P., Freeman C.O., Burke D.J.

Genetics 172:53-65(2006) SGD S000005584 · Mapped (29)
Large-scale genetic interaction SGD S000005584

NoCut: cytokinesis in check.

Bloom K.

Cell 125:17-18(2006) SGD S000005584 · Mapped (10)
Reviews SGD S000005584

The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage.

Norden C., Mendoza M., Dobbelaere J., Kotwaliwale C.V., Biggins S., Barral Y.

Cell 125:85-98(2006) SGD S000005584 · Mapped (12)
Cell Cycle Phase Involved|Function/Process|Mutants/Phenotypes|Non-Fungal Related Genes/Proteins|Strains/Constructs SGD S000005584

Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins.

Crasta K., Huang P., Morgan G., Winey M., Surana U.

EMBO J. 25:2551-2563(2006) SGD S000005584 · Mapped (9)
Genetic Interactions|Mutants/Phenotypes|Protein Processing/Modification/Regulation|Strains/Constructs SGD S000005584

Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes.

Crasta K., Surana U.

Cell Div 1:12-12(2006) SGD S000005584 · Mapped (23)
Reviews SGD S000005584

A three-hybrid screen identifies mRNAs controlled by a regulatory protein.

Seay D., Hook B., Evans K., Wickens M.

RNA 12:1594-1600(2006) SGD S000005584 · Mapped (7)
RNA Levels and Processing SGD S000005584

Cdc14-regulated midzone assembly controls anaphase B.

Khmelinskii A., Lawrence C., Roostalu J., Schiebel E.

J. Cell Biol. 177:981-993(2007) SGD S000005584 · Mapped (7)
Cellular Location|Function/Process|Mutants/Phenotypes|Protein Processing/Modification/Regulation|Protein Sequence Features|Protein-protein Interactions|Strains/Constructs SGD S000005584

Prediction of cyclin-dependent kinase phosphorylation substrates.

Chang E.J., Begum R., Chait B.T., Gaasterland T.

PLoS ONE 2:e656-e656(2007) SGD S000005584 · Mapped (94)
S000005584 SGD S000005584

A pathway containing the Ipl1/aurora protein kinase and the spindle midzone protein Ase1 regulates yeast spindle assembly.

Kotwaliwale C.V., Frei S.B., Stern B.M., Biggins S.

Dev. Cell 13:433-445(2007) SGD S000005584 GeneRIF 854223 · Mapped (3)
A pathway regulating IPL1 and the spindle midzone protein Ase1 regulates spindle assembly. GeneRIF 854223 Cellular Location|Function/Process|Genetic Interactions|Mutants/Phenotypes|Protein Processing/Modification/Regulation|Strains/Constructs SGD S000005584

Cytokinesis: placing and making the final cut.

Barr F.A., Gruneberg U.

Cell 131:847-860(2007) SGD S000005584 · Mapped (7)
Reviews SGD S000005584

The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle.

Gardner M.K., Haase J., Mythreye K., Molk J.N., Anderson M., Joglekar A.P., O'Toole E.T., Winey M., Salmon E.D., Odde D.J. et al.

J. Cell Biol. 180:91-100(2008) SGD S000005584 · Mapped (6)
Function/Process|Mutants/Phenotypes|Strains/Constructs SGD S000005584

Annotating novel genes by integrating synthetic lethals and genomic information.

Schoner D., Kalisch M., Leisner C., Meier L., Sohrmann M., Faty M., Barral Y., Peter M., Gruissem W., Buhlmann P.

BMC Syst Biol 2:3-3(2008) SGD S000005584 · Mapped (10)
Function/Process|Genetic Interactions|Mutants/Phenotypes SGD S000005584

Assembling the spindle midzone in the right place at the right time.

Khmelinskii A., Schiebel E.

Cell Cycle 7:283-286(2008) SGD S000005584 GeneRIF 854223 · Mapped (4)
Cell Cycle Phase Involved|Cellular Location|DNA/RNA Sequence Features|Function/Process|Mutants/Phenotypes|Protein-protein Interactions|Regulation of|Strains/Constructs SGD S000005584 Review identifies Ase1 as a key Cdc14 substrate and elucidates the coordination of spindle midzone assembly with metaphase to anaphase transition. GeneRIF 854223

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