Giannini G., Ristori E., Cerignoli F., Rinaldi C., Zani M., Viel A., Ottini L., Crescenzi M., Martinotti S., Bignami M. et al.

EMBO Rep. 3:248-254(2002) GeneRIF 4361 · Mapped (9)
Major target for inactivation in mismatch repair-defective cells and may contribute to the development of colorectal cancer. GeneRIF 4361

Stracker T.H., Carson C.T., Weitzman M.D.

Nature 418:348-352(2002) GeneRIF 4361 · UniProtKB (3) · Mapped (4)
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex GeneRIF 4361

Furuta T., Takemura H., Liao Z.-Y., Aune G.J., Redon C., Sedelnikova O.A., Pilch D.R., Rogakou E.P., Celeste A., Chen H.T. et al.

J. Biol. Chem. 278:20303-20312(2003) GeneRIF 4361 · UniProtKB (2) · Mapped (4)
activation in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes GeneRIF 4361

Carson C.T., Schwartz R.A., Stracker T.H., Lilley C.E., Lee D.V., Weitzman M.D.

EMBO J. 22:6610-6620(2003) GeneRIF 4361 · Mapped (4)
Mre11 complex is required for both ATM activation and the ATM-dependent G(2)/M checkpoint in response to double stranded breaks. GeneRIF 4361

Cheng W.H., von Kobbe C., Opresko P.L., Arthur L.M., Komatsu K., Seidman M.M., Carney J.P., Bohr V.A.

J. Biol. Chem. 279:21169-21176(2004) GeneRIF 4361 · Mapped (6)
WRN associates with the Mre11 complex via binding to Nbs1 in vitro and in vivo. GeneRIF 4361

Arthur L.M., Gustausson K., Hopfner K.P., Carson C.T., Stracker T.H., Karcher A., Felton D., Weitzman M.D., Tainer J., Carney J.P.

Nucleic Acids Res. 32:1886-1893(2004) GeneRIF 4361 · Mapped (5)
Functional and structural characterization of a nuclease-deficient Mre11 protein termed mre11-3. GeneRIF 4361

Giannini G., Rinaldi C., Ristori E., Ambrosini M.I., Cerignoli F., Viel A., Bidoli E., Berni S., D'Amati G., Scambia G. et al.

Oncogene 23:2640-2647(2004) GeneRIF 4361 · Mapped (9)
MRE11 is a new common target in the mismatch repair deficient tumorigenesis and has a role in colorectal carcinogenesis GeneRIF 4361

Robison J.G., Elliott J., Dixon K., Oakley G.G.

J. Biol. Chem. 279:34802-34810(2004) GeneRIF 4361 · Mapped (6)
Replication protein A Mre11 Rad50 and Nbs1 bind and have roles in DNA repair GeneRIF 4361

Xu M., Myerson R.J., Hunt C., Kumar S., Moros E.G., Straube W.L., Roti Roti J.L.

Int J Hyperthermia 20:157-162(2004) GeneRIF 4361 · Mapped (4)
Two hours at 41 degrees C did not increase the radiation sensitivity of cells with a reduced Mre11 protein level following a 24-h siRNA treatment. GeneRIF 4361

Cerosaletti K., Concannon P.

J. Biol. Chem. 279:38813-38819(2004) GeneRIF 4361 · Mapped (4)
Nibrin Mre11 and Rad50 also act as adaptors for some downstream Atm phosphorylation events GeneRIF 4361

Delia D., Piane M., Buscemi G., Savio C., Palmeri S., Lulli P., Carlessi L., Fontanella E., Chessa L.

Hum. Mol. Genet. 13:2155-2163(2004) GeneRIF 4361 · Mapped (4)
MRE11 gene mutations affected ATM-dependent responses in radiosensitive ataxia-telangiectasia-like disorder family. GeneRIF 4361

Ottini L., Falchetti M., Saieva C., De Marco M., Masala G., Zanna I., Paglierani M., Giannini G., Gulino A., Nesi G. et al.

Carcinogenesis 25:2337-2343(2004) GeneRIF 4361 · Mapped (9)
MRE11 expression is impaired in gastric cancer with microsatellite instability GeneRIF 4361

Jacobsen E., Beach T., Shen Y., Li R., Chang Y.

Brain Res. Mol. Brain Res. 128:1-7(2004) GeneRIF 4361 · Mapped (9)
Data show that Mre11 complex proteins are present in neurons of the adult human cortex and cerebellum and suggest that loss of the complex may be associated with the pathogenesis of Alzheimer disease. GeneRIF 4361

Fernet M., Gribaa M., Salih M.A., Seidahmed M.Z., Hall J., Koenig M.

Hum. Mol. Genet. 14:307-318(2005) GeneRIF 4361 · Mapped (9)
early-onset slowly progressive ataxia plus ocular apraxia phenotype = ataxia telangiectasia-like disorder (ATLD) GeneRIF 4361

Robison J.G., Lu L., Dixon K., Bissler J.J.

J. Biol. Chem. 280:12927-12934(2005) GeneRIF 4361 · Mapped (6)
the Mre11/Rad50/Nbs1 (MRN) complex may play a more universal role in the recognition and response to DNA lesions of all types whereas the role of RPA may be limited to certain subsets of lesions GeneRIF 4361

Lee J.H., Paull T.T.

Science 308:551-554(2005) GeneRIF 4361 · Mapped (4)
findings show that the Mre11-Rad50-Nbs1 (MRN) complex acts as a double-strand break sensor for ATM and recruits ATM to broken DNA molecules GeneRIF 4361

Vo A.T., Zhu F., Wu X., Yuan F., Gao Y., Gu L., Li G.M., Lee T.H., Her C.

EMBO Rep. 6:438-444(2005) GeneRIF 4361 · Mapped (4)
hMRE11 represents a functional component of the DNA mismatch repair pathway GeneRIF 4361

Yabuki M., Fujii M.M., Maizels N.

Nat. Immunol. 6:730-736(2005) GeneRIF 4361 · Mapped (4)
The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions. GeneRIF 4361

Boisvert F.M., Hendzel M.J., Masson J.Y., Richard S.

Cell Cycle 4:981-989(2005) GeneRIF 4361 · Mapped (4)
These results suggest that MRE11 methylation regulates its association with nuclear structures such as PML nuclear bodies and sites of DNA damage. GeneRIF 4361

Moreno-Herrero F., de Jager M., Dekker N.H., Kanaar R., Wyman C., Dekker C.

Nature 437:440-443(2005) GeneRIF 4361 · Mapped (4)
the dynamic architecture of human Rad50/Mre11/Nbs1 is markedly affected by DNA binding GeneRIF 4361

Liu Y., Shevchenko A., Shevchenko A., Berk A.J.

J. Virol. 79:14004-14016(2005) GeneRIF 4361 · Mapped (4)
Adenovirus 5 exploits the cellular aggresome response to accelerate inactivation of MRE11-RAD50-NBS1 (MRN) complexes that otherwise inhibit viral DNA replication and packaging. GeneRIF 4361

Jazayeri A., Falck J., Lukas C., Bartek J., Smith G.C., Lukas J., Jackson S.P.

Nat. Cell Biol. 8:37-45(2006) GeneRIF 4361 · Mapped (4)
We show that Mre11 are required for the processing of DNA double-strand breaks (DSBs) to generate the replication protein A (RPA)-coated ssDNA that is needed for ATR recruitment and the subsequent phosphorylation and activation of Chk1. GeneRIF 4361

van der Heijden M.S., Brody J.R., Elghalbzouri-Maghrani E., Zdzienicka M.Z., Kern S.E.

BMC Genet. 7:3-3(2006) GeneRIF 4361 · Mapped (22)
the data are not compatible with selective pressures during tumorigenesis promoting the functional loss of BRCA2 and MRE11 in microsatellite unstable tumors but fit closely with an absence of selective pressures acting on BRCA2 and MRE11 gene status GeneRIF 4361

Myers J.S., Cortez D.

J. Biol. Chem. 281:9346-9350(2006) GeneRIF 4361 · Mapped (5)
ATM and Mre11 may stimulate the ATR signaling pathway by converting DNA damage generated by ionizing radiation into structures that recruit and activate ATR GeneRIF 4361

Sheen M.R., Kim S.W., Jung J.Y., Ahn J.Y., Rhee J.G., Kwon H.M., Woo S.K.

Am. J. Physiol. Renal Physiol. 291:F1014-20(2006) GeneRIF 4361 · Mapped (4)
the Mre11-Rad50-Nbs1 complex stayed in the nucleus and remained intact in response to hypertonicity GeneRIF 4361