McAllister K.A., Wiseman R.W.

Breast Cancer Res. 4:54-57(2002) GeneRIF 12189 · Mapped (7)
role in multiple complex biological pathways including DNA damage repair transcriptional regulation and cell-cycle checkpoint control GeneRIF 12189

Bachelier R., Vincent A., Mathevet P., Magdinier F., Lenoir G.M., Frappart L.

Virchows Arch. 440:261-266(2002) GeneRIF 12189 · Mapped (10)
The results suggest that Brca 1 proteins have a role in hyperplastic development of epithelial mammary cells in mice. GeneRIF 12189

Zhong Q., Chen C.F., Chen P.L., Lee W.H.

J. Biol. Chem. 277:28641-28647(2002) GeneRIF 12189 · Mapped (7)
Brca1 has an essential role in microhomology-mediated end joining GeneRIF 12189

Bachelier R., Xu X., Wang X., Li W., Naramura M., Gu H., Deng C.X.

Oncogene 22:528-537(2003) GeneRIF 12189 MGI 104537 · Mapped (18)
deletion of Brca1 exon 11 (Brca1-delta11) which disrupts the full-length isoform but not the short isoform of Brca1 does not interfere with lymphocyte development GeneRIF 12189

Baker K.M., Wei G., Schaffner A.E., Ostrowski M.C.

J. Biol. Chem. 278:17876-17884(2003) GeneRIF 12189 · Mapped (16)
BRCA1 is regulated by Ets-2 and components of mammalian SWI/SNF GeneRIF 12189

Baldassarre G., Battista S., Belletti B., Thakur S., Pentimalli F., Trapasso F., Fedele M., Pierantoni G., Croce C.M., Fusco A.

Mol. Cell. Biol. 23:2225-2238(2003) GeneRIF 12189 · Mapped (7)
HMGA1 proteins are involved in transcriptional regulation of the BRCA1 gene and their overexpression may have a role in BRCA1 downregulation observed in aggressive mammary carcinomas GeneRIF 12189

Deng C.X., Wang R.H.

Hum. Mol. Genet. 12 Spec No 1:R113-23(2003) GeneRIF 12189 · Mapped (7)
BRCA1 has roles in DNA damage repair and cellular responses that link development and cancer [review] GeneRIF 12189

Fedier A., Steiner R.A., Schwarz V.A., Lenherr L., Haller U., Fink D.

Int. J. Oncol. 22:1169-1173(2003) GeneRIF 12189 · Mapped (25)
The effect of the loss of this gene increases the sensitivity of cells to anticancer agents in p53 deficient cells. GeneRIF 12189

Ongusaha P.P., Ouchi T., Kim K.T., Nytko E., Kwak J.C., Duda R.B., Deng C.X., Lee S.W.

Oncogene 22:3749-3758(2003) GeneRIF 12189 · Mapped (7)
BRCA1 is involved in p53-mediated growth suppression rather than apoptosis. GeneRIF 12189

Berton T.R., Matsumoto T., Page A., Conti C.J., Deng C.X., Jorcano J.L., Johnson D.G.

Oncogene 22:5415-5426(2003) GeneRIF 12189 MGI 104537 · Mapped (7)
Functions as a tumor suppressor in other epithelia in addition to the mammary gland. GeneRIF 12189

Westermark U.K., Reyngold M., Olshen A.B., Baer R., Jasin M., Moynahan M.E.

Mol. Cell. Biol. 23:7926-7936(2003) GeneRIF 12189 · Mapped (24)
Data show that expression of truncated mouse or human BARD1 peptides capable of interacting with Brca1 results in a homologous-repair deficiency. GeneRIF 12189

Xiong J., Fan S., Meng Q., Schramm L., Wang C., Bouzahza B., Zhou J., Zafonte B., Goldberg I.D., Haddad B.R. et al.

Mol. Cell. Biol. 23:8668-8690(2003) GeneRIF 12189 · Mapped (7)
exogenous wtBRCA1 strongly suppressed TERT promoter activity in various cell lines GeneRIF 12189

Ouchi M., Fujiuchi N., Sasai K., Katayama H., Minamishima Y.A., Ongusaha P.P., Deng C., Sen S., Lee S.W., Ouchi T.

J. Biol. Chem. 279:19643-19648(2004) GeneRIF 12189 · UniProtKB (2) · Mapped (15)
BRCA1 phosphorylation by Aurora-A plays a role in G(2) to M transition of cell cycle GeneRIF 12189

Wang X., Wang R.H., Li W., Xu X., Hollander M.C., Fornace A.J. Jr., Deng C.X.

J. Biol. Chem. 279:29606-29614(2004) GeneRIF 12189 MGI 104537 · Mapped (69)
These observations suggest that NEK2 plays a role in mediating the actions of BRCA1 and GADD45a in regulating centrosome duplication and in maintaining genetic stability. GeneRIF 12189

Kitagawa R., Bakkenist C.J., McKinnon P.J., Kastan M.B.

Genes Dev. 18:1423-1438(2004) GeneRIF 12189 · Mapped (16)
observations suggest that many of the abnormal stress responses seen in cells lacking ATM NBS1 or BRCA1 result from a failure of ATM migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation. GeneRIF 12189

Yun J., Zhong Q., Kwak J.Y., Lee W.H.

Oncogene 24:4009-4016(2005) GeneRIF 12189 · Mapped (7)
Brca1 directly plays an essential role in interssrsand crosslinking repair which depends on homologous recombination during S phase. GeneRIF 12189

Ma Y., Katiyar P., Jones L.P., Fan S., Zhang Y., Furth P.A., Rosen E.M.

Mol. Endocrinol. 20:14-34(2006) GeneRIF 12189 · Mapped (7)
BRCA1 regulates the activity of progesterone a major hormone of pregnancy that may also participate in mammary carcinogenesis. GeneRIF 12189

Smolen G.A., Muir B., Mohapatra G., Barmettler A., Kim W.J., Rivera M.N., Haserlat S.M., Okimoto R.A., Kwak E., Dahiya S. et al.

Cancer Res. 66:3452-3455(2006) GeneRIF 12189 MGI 104537 · Mapped (35)
Identification of a dominant somatic genetic lesion in the Brca1/Trp53 mouse model suggests that recurrent secondary hits may also exist in BRCA1-initiated human breast cancer. GeneRIF 12189

Muraoka-Cook R.S., Caskey L.S., Sandahl M.A., Hunter D.M., Husted C., Strunk K.E., Sartor C.I., Rearick W.A. Jr., McCall W., Sgagias M.K. et al.

Mol. Cell. Biol. 26:6412-6424(2006) GeneRIF 12189 · Mapped (14)
These results suggest that heregulin-mediated growth inhibition in HER4-postive breast cancer cells requires BRCA1. GeneRIF 12189

Evers B., Jonkers J.

Oncogene 25:5885-5897(2006) GeneRIF 12189 · Mapped (11)
Whereas conventional Brca1 and Brca2 mouse mutants did not reveal a strong phenotype in a heterozygous setting most homozygous mutations caused embryonic lethality. [REVIEW] GeneRIF 12189

Tominaga Y., Wang A., Wang R.H., Wang X., Cao L., Deng C.X.

Cell Death Differ. 14:472-479(2007) GeneRIF 12189 · Mapped (7)
Our data indicated that Brca1 mutant cells were more sensitive to genistein than some other types of cancer cells highlighting a good therapeutic potential of genistein for BRCA1-associated breast cancer. GeneRIF 12189

Pageau G.J., Lawrence J.B.

J. Cell Biol. 175:693-701(2006) GeneRIF 12189 MGI 104537 · Mapped (7)
These findings implicate BRCA1 in replication-linked maintenance of centric/pericentric heterochromatin and suggest a novel means whereby BRCA1 loss may contribute to genomic instability and cancer. GeneRIF 12189

Wang X., Liu L., Montagna C., Ried T., Deng C.X.

Cell Death Differ. 14:924-931(2007) GeneRIF 12189 MGI 104537 · Mapped (21)
Haploinsufficiency of Parp1 in Brca1(Delta11/Delta11) embryos induces a severe chromosome aberrations centrosome amplification and telomere dysfunction leading to apoptosis and accelerated embryonic lethality. GeneRIF 12189

Cao L., Xu X., Cao L.L., Wang R.H., Coumoul X., Kim S.S., Deng C.X.

Carcinogenesis 28:1401-1407(2007) GeneRIF 12189 MGI 104537 · Mapped (18)
Brca1 is involved in renewable organ homeostasis linking the environmental and genetic factors in carcinogenesis and aging and providing new insights into genomic instability in organism maintenance and tumorigenesis. GeneRIF 12189

Jeng Y.M., Cai-Ng S., Li A., Furuta S., Chew H., Chen P.L., Lee E.Y., Lee W.H.

Oncogene 26:6160-6166(2007) GeneRIF 12189 MGI 104537 · Mapped (7)
Mutation heterozygotes may be more prone to ovarian tumor formation after ionizing radiation exposure than nonmutation carriers. GeneRIF 12189