Nakamura S., Kugiyama K., Sugiyama S., Miyamoto S., Koide S., Fukushima H., Honda O., Yoshimura M., Ogawa H.

Circulation 105:2968-2973(2002) GAD 123885 GeneRIF 2730 · Mapped (3)
Associated with CARDIOVASCULAR: myocardial infarction; GAD 123885 Polymorphism in the 5'-flanking region is associated with myocardial infarction; Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Nakamura S., Sugiyama S., Fujioka D., Kawabata K., Ogawa H., Kugiyama K.

Circulation 108:1425-1427(2003) GAD 123886 GeneRIF 2730 · Mapped (10)
Associated with CARDIOVASCULAR: atherosclerosis, coronary; GAD 123886 Observational study of gene-disease association. (HuGE Navigator); A -588T polymorphism of the GCLM gene causes a decrease in endothelial NO bioactivity causing impairment of endothelium-dependent vasomotor function in large and resistance coronary arteries. The GCL-GSH-NO axis may defend against coronary artery disease GeneRIF 2730

Hu R.C., Tan S.X., Dai A.G.

Zhonghua Jie He He Hu Xi Za Zhi 29:100-103(2006) GAD 147952 GeneRIF 2730 · Mapped (3)
Associated with IMMUNE: chronic obstructive pulmonary disease/COPD; GAD 147952 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator); The polymorphism of GCLM -588C/T and -23G/T sites were associated with susceptibility to COPD. GeneRIF 2730

Inoue Y., Tomisawa M., Yamazaki H., Abe Y., Suemizu H., Tsukamoto H., Tomii Y., Kawamura M., Kijima H., Hatanaka H. et al.

Int. J. Oncol. 23:1333-1339(2003) GeneRIF 2730 · Mapped (3)
GCLM has a role in cisplatin (CDDP)-resistance in lung cancer GeneRIF 2730

Dickinson D.A., Levonen A.L., Moellering D.R., Arnold E.K., Zhang H., Darley-Usmar V.M., Forman H.J.

Free Radic. Biol. Med. 37:1152-1159(2004) GeneRIF 2730 · Mapped (7)
Review. The most important element in both Gclc and Gclm expression is the electrophile response element in their promoters. GeneRIF 2730

Song I.S., Tatebe S., Dai W., Kuo M.T.

J. Biol. Chem. 280:28230-28240(2005) GeneRIF 2730 · Mapped (8)
Reduction-oxidation regulation of gamma-GCSh expression is mediated by p38 mitogen-activated protein kinase signaling. GeneRIF 2730

Chen Y., Shertzer H.G., Schneider S.N., Nebert D.W., Dalton T.P.

J. Biol. Chem. 280:33766-33774(2005) GeneRIF 2730 · Mapped (11)
in most tissues glutanmate-cysteine ligase modifier submit (GCLM) is limiting suggesting an increase in GCLM alone would increase gamma-GC synthesis; in kidney gamma-GC synthesis may be controlled post-translationally GeneRIF 2730

Custodio H.M., Broberg K., Wennberg M., Jansson J.H., Vessby B., Hallmans G., Stegmayr B., Skerfving S.

Arch. Environ. Health 59:588-595(2004) GeneRIF 2730 · Mapped (23)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Bekris L.M., Viernes H.M., Farin F.M., Maier L.A., Kavanagh T.J., Takaro T.K.

J. Occup. Environ. Med. 48:599-606(2006) GeneRIF 2730 · Mapped (7)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Tosic M., Ott J., Barral S., Bovet P., Deppen P., Gheorghita F., Matthey M.L., Parnas J., Preisig M., Saraga M. et al.

Am. J. Hum. Genet. 79:586-592(2006) GeneRIF 2730 · Mapped (3)
The gene of the key GSH-synthesizing enzyme glutamate cysteine ligase modifier (GCLM) subunit is strongly associated with schizophrenia in two case-control studies and in one family study. GeneRIF 2730

Jonsson L.S., Broberg K., Bergendorf U., Axmon A., Littorin M., Jonsson B.A.

Int Arch Occup Environ Health 80:589-598(2007) GeneRIF 2730 · Mapped (23)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 2730

Aguirre P., Valdes P., Aracena-Parks P., Tapia V., Nunez M.T.

Am. J. Physiol., Cell Physiol. 292:C2197-203(2007) GeneRIF 2730 · Mapped (7)
upregulation of gamma-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neurons GeneRIF 2730

Baum L., Chen X., Cheung W.S., Cheung C.K., Cheung L.W., Chiu K.F., Wen H.M., Poon P., Woo K.S., Ng H.K. et al.

J Geriatr Psychiatry Neurol 20:93-99(2007) GeneRIF 2730 · Mapped (3)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Polonikov A.V., Ivanov V.P., Solodilova M.A., Khoroshaya I.V., Kozhuhov M.A., Panfilov V.I.

Respir Med 101:2422-2424(2007) GeneRIF 2730 · Mapped (7)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Muehlhause A., Kropf S., Gardemann A.

Clin. Chem. Lab. Med. 45:1416-1418(2007) GeneRIF 2730 · Mapped (3)
the present data strongly indicates that in spite of its functional impact the GCLM C-588T polymorphism is - at least in a German cohort - not an independent risk indicator of coronary artery disease and myocardial infarction GeneRIF 2730

Zuo H.P., Xu W.J., Luo M., Zhu Z.Z., Zhu G.S.

Zhonghua Xin Xue Guan Bing Za Zhi 35:637-640(2007) GeneRIF 2730 · Mapped (7)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Jonsson L.S., Jonsson B.A., Axmon A., Littorin M., Broberg K.

Int Arch Occup Environ Health 81:913-919(2008) GeneRIF 2730 · Mapped (23)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 2730

Matsuzawa D., Hashimoto K., Hashimoto T., Shimizu E., Watanabe H., Fujita Y., Iyo M.

Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B:86-94(2009) GeneRIF 2730 · Mapped (28)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Schlawicke Engstrom K., Stromberg U., Lundh T., Johansson I., Vessby B., Hallmans G., Skerfving S., Broberg K.

Environ. Health Perspect. 116:734-739(2008) GeneRIF 2730 · Mapped (10)
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) GeneRIF 2730

Chappell S., Daly L., Morgan K., Guetta-Baranes T., Roca J., Rabinovich R., Lotya J., Millar A.B., Donnelly S.C., Keatings V. et al.

Eur. Respir. J. 32:931-937(2008) GeneRIF 2730 · Mapped (9)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Kishi T., Ikeda M., Kitajima T., Yamanouchi Y., Kinoshita Y., Kawashima K., Inada T., Harano M., Komiyama T., Hori T. et al.

Ann. N. Y. Acad. Sci. 1139:63-69(2008) GeneRIF 2730 · Mapped (3)
Observational study of gene-disease association. (HuGE Navigator); Results suggest that a common genetic variation in the GCLM gene might not contribute to the risk of methamphetamine-use disorder and schizophrenia in the Japanese population. GeneRIF 2730

Yoshida T., Kato K., Fujimaki T., Yokoi K., Oguri M., Watanabe S., Metoki N., Yoshida H., Satoh K., Aoyagi Y. et al.

Genomics 93:221-226(2009) GeneRIF 2730 · Mapped (324)
Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730

Katakami N., Sakamoto K., Kaneto H., Matsuhisa M., Shimizu I., Ishibashi F., Osonoi T., Kashiwagi A., Kawamori R., Hori M. et al.

Biochem. Biophys. Res. Commun. 379:861-865(2009) GeneRIF 2730 · Mapped (10)
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) GeneRIF 2730

Cortes-Wanstreet M.M., Giedzinski E., Limoli C.L., Luderer U.

Mutagenesis 24:211-224(2009) GeneRIF 2730 · Mapped (3)
Overexpression of GCL in granulosa cells can augment glutathione synthesis and ameliorate various sequelae associated with exposure to oxidative stress and irradiation. GeneRIF 2730

Yamamoto R., Nagasawa Y., Shoji T., Inoue K., Uehata T., Kaneko T., Okada T., Yamauchi A., Tsubakihara Y., Imai E. et al.

Nephrol. Dial. Transplant. 24:3686-3694(2009) GeneRIF 2730 GAD 577631 · Mapped (499)
Not Associated with IMMUNE: Glomerulonephritis, IGA; GAD 577631 Observational study of gene-disease association. (HuGE Navigator) GeneRIF 2730