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Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins.

Parnell S.C., Magenheimer B.S., Maser R.L., Zien C.A., Frischauf A.M., Calvet J.P.

J. Biol. Chem. 277:19566-19572(2002) GeneRIF 5599 · Mapped (21)
Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins GeneRIF 5599

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.

Zhang J., Kalkum M., Chait B.T., Roeder R.G.

Mol. Cell 9:611-623(2002) GeneRIF 5599 · UniProtKB (6) · Mapped (23)
Results show that the N-CoR-HDAC3 complex inhibits JNK activation through the associated GPS2 subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP-1 function. GeneRIF 5599

Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis.

Gabai V.L., Mabuchi K., Mosser D.D., Sherman M.Y.

Mol. Cell. Biol. 22:3415-3424(2002) GeneRIF 5599 · Mapped (30)
These data strongly suggest that in TNF-induced apoptosis Hsp72 specifically interferes with the Bid-dependent apoptotic pathway via inhibition of JNK. GeneRIF 5599

A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.

Holmberg C., Katz S., Lerdrup M., Herdegen T., Jaattela M., Aronheim A., Kallunki T.

J. Biol. Chem. 277:31918-31928(2002) GeneRIF 5599 · Mapped (13)
novel role for the I kappa B kinase complex-associated protein (IKAP) in the regulation of activation of the mammalian stress response via the c-Jun N-terminal kinase (JNK)-signaling pathway GeneRIF 5599

The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.

Kim G.Y., Mercer S.E., Ewton D.Z., Yan Z., Jin K., Friedman E.

J. Biol. Chem. 277:29792-29802(2002) GeneRIF 5599 · Mapped (9)
role in stabilizing p21(Cip1) by phosphorylation GeneRIF 5599

Induced proliferation of human MRC-5 cells by nitrogen oxides via direct and indirect activation of MEKK1, JNK, and p38 signals.

Chou F.P., Tseng T.H., Chen J.H., Wang H.C., Wang C.J.

Toxicol. Appl. Pharmacol. 181:203-208(2002) GeneRIF 5599 · Mapped (10)
the NOx-induced cell proliferation via activation of JNK1 might contribute to lung tissue damage caused by NOx GeneRIF 5599

Galpha13 induces preproET-1 gene expression via JNK.

Yamakaw K., Kitamura K., Nonoguchi H., Takasu N., Miller R.T., Tomita K.

Hypertens. Res. 25:427-432(2002) GeneRIF 5599 · Mapped (7)
Galpha13 can induce ppET-1 gene expression through a JNK-mediated pathway. GeneRIF 5599

Elevated JNK activation contributes to the pathogenesis of human brain tumors.

Antonyak M.A., Kenyon L.C., Godwin A.K., James D.C., Emlet D.R., Okamoto I., Tnani M., Holgado-Madruga M., Moscatello D.K., Wong A.J.

Oncogene 21:5038-5046(2002) GeneRIF 5599 · Mapped (4)
Elevated JNK activation contributes to the pathogenesis of human brain tumors GeneRIF 5599

Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells.

Liedtke C., Plumpe J., Kubicka S., Bradham C.A., Manns M.P., Brenner D.A., Trautwein C.

Hepatology 36:315-325(2002) GeneRIF 5599 · Mapped (4)
Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells GeneRIF 5599

Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia.

Brunner C., Kreth H.W., Ochs H.D., Schuster V.

J. Clin. Immunol. 22:244-251(2002) GeneRIF 5599 · Mapped (4)
Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia. GeneRIF 5599

Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis.

Saeki K., Kobayashi N., Inazawa Y., Zhang H., Nishitoh H., Ichijo H., Saeki K., Isemura M., Yuo A.

Biochem. J. 368:705-720(2002) GeneRIF 5599 · Mapped (9)
description of the signaling of JNK and p38 MAPK in apoptosis after stimulation by antioxidants GeneRIF 5599

TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB.

Lee S.W., Han S.I., Kim H.H., Lee Z.H.

J. Biochem. Mol. Biol. 35:371-376(2002) GeneRIF 5599 · Mapped (15)
TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. GeneRIF 5599

Differential gene regulation by specific gain-of-function JNK1 proteins expressed in Swiss 3T3 fibroblasts.

Han S.Y., Kim S.H., Heasley L.E.

J. Biol. Chem. 277:47167-47174(2002) GeneRIF 5599 · Mapped (10)
JNK has isoform-selective gene regulation and distinct JNK isoforms have a role in specific cellular responses GeneRIF 5599

Relationship of Mcl-1 isoforms, ratio p21WAF1/cyclin A, and Jun kinase phosphorylation to apoptosis in human breast carcinomas.

Rieber M., Medina J.D., Strasberg-Rieber M.

Biochem. Biophys. Res. Commun. 297:943-949(2002) GeneRIF 5599 · Mapped (10)
Relationship of Mcl-1 isoforms ratio p21WAF1/cyclin A and this protein phosphorylation to apoptosis in human breast carcinomas. GeneRIF 5599

Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis.

Takahashi H., Ibe M., Nakamura S., Ishida-Yamamoto A., Hashimoto Y., Iizuka H.

J. Dermatol. Sci. 30:94-99(2002) GeneRIF 5599 · Mapped (4)
Psoriatic epidermis shows selective activation of ERK and JNK which might be related to hyperproliferation and abnormal differentiation of psoriatic epidermis. GeneRIF 5599

Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression.

Gee K., Lim W., Ma W., Nandan D., Diaz-Mitoma F., Kozlowski M., Kumar A.

J. Immunol. 169:5660-5672(2002) GeneRIF 5599 · Mapped (4)
JNK activation is predominantly involved in the induction of CD44 expression in monocytic cells via lipopolysaccharide-mediated signaling. GeneRIF 5599

Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.

Kang H.J., Soh Y., Kim M.S., Lee E.J., Surh Y.J., Kim H.R., Kim S.H., Moon A.

Int. J. Cancer 103:475-482(2003) GeneRIF 5599 · Mapped (12)
JNK-1 and p38 play a role in apoptosis induced by capsaicin in H-ras-transformed tumor cells GeneRIF 5599

C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.

Yang Y.M., Bost F., Charbono W., Dean N., McKay R., Rhim J.S., Depatie C., Mercola D.

Clin. Cancer Res. 9:391-401(2003) GeneRIF 5599 · Mapped (10)
JNK is required for growth of prostate carcinoma cells in vitro and in vivo GeneRIF 5599

ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.

Wen-Sheng W.

Oncogene 22:955-963(2003) GeneRIF 5599 · Mapped (39)
Western blot demonstrated that phosphorylation of JNK was induced only by TPA during 30 min to 1 h. GeneRIF 5599

Uncoupling of protein kinase D from suppression of EGF-dependent c-Jun phosphorylation in cancer cells.

Hurd C., Rozengurt E.

Biochem. Biophys. Res. Commun. 302:800-804(2003) GeneRIF 5599 · Mapped (6)
Data suggest that epidermal growth factor (EGF) stimulated c-Jun N-terminal kinase phosphorylation of c-Jun is uncoupled from protein kinase D suppression in cancer cells. GeneRIF 5599

c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells.

Vivo C., Liu W., Broaddus V.C.

J. Biol. Chem. 278:25461-25467(2003) GeneRIF 5599 · Mapped (7)
JNK1 has a role in the synergistic effect of TRAIL combined with DNA damage by mediating signals independent of p53 leading to apoptosis GeneRIF 5599

Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells.

Zhang J., Li W., Sumpio B.E., Basson M.D.

Biochem. Biophys. Res. Commun. 306:746-749(2003) GeneRIF 5599 · Mapped (9)
Results suggest that tissue or plasma fibronectin may modulate the intestinal epithelial response to repetitive deformation through inhibted activation of p38 and jun kinases. GeneRIF 5599

c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production.

Utsugi M., Dobashi K., Ishizuka T., Endou K., Hamuro J., Murata Y., Nakazawa T., Mori M.

J. Immunol. 171:628-635(2003) GeneRIF 5599 · Mapped (4)
c-Jun N-terminal kinase plays a negative role in the production of IL-12 from human macrophages stimulated by lipopolysaccharide. GeneRIF 5599

Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase.

Ghosh J.

Biochem. Biophys. Res. Commun. 307:342-349(2003) GeneRIF 5599 · Mapped (11)
Data show that inhibition of arachidonate 5-lipoxygenase induces rapid activation of c-Jun N-terminal kinase (JNK) in human prostate cancer cells which is prevented by the 5-lipoxygenase metabolite 5(S)-HETE. GeneRIF 5599

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.

Luo W., Ng W.W., Jin L.H., Ye Z., Han J., Lin S.C.

J. Biol. Chem. 278:37451-37458(2003) GeneRIF 5599 · Mapped (29)
Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. GeneRIF 5599

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