Wang Y., Yang S.X., Tu P., Zhang B., Ma S.Q.

J. Dermatol. Sci. 30:136-141(2002) GeneRIF 19228 · Mapped (2)
The variety of the PTH/PTHrP receptor mRNA expression during hair cycling suggest that PTH PTHrP and their receptors might participate in the regulation of hair cycle in mice skin. GeneRIF 19228

Czykier E., Zabel M., Seidel J.

Folia Histochem. Cytobiol. 41:29-32(2003) GeneRIF 19228 · Mapped (2)
Pthr immunoreactivity was demonstrated in epithelial cells of striated interlobular and main excretory ducts of the sublingual gland. It was absent in the epithelial cells of the intercalated ducts. GeneRIF 19228

Noonan W.T., Qian J., Stuart W.D., Clemens T.L., Lorenz J.N.

Endocrinology 144:4931-4938(2003) GeneRIF 19228 · Mapped (2)
Smooth-muscle-specific overexpression of PTH/PTHrP type 1 receptor resulted in more vasodilation to saline volume expansion and less vasoconstriction to ANG II. Can act as endogenous vasorelaxant factor to modulate renal responses to vasoactive stimuli. GeneRIF 19228

Bastepe M., Weinstein L.S., Ogata N., Kawaguchi H., Juppner H., Kronenberg H.M., Chung U.I.

Proc. Natl. Acad. Sci. U.S.A. 101:14794-14799(2004) GeneRIF 19228 · Mapped (2)
Gsalpha is the primary mediator of the actions of the Pthrp receptor in growth plate chondrocytes. GeneRIF 19228

Kuznetsov S.A., Riminucci M., Ziran N., Tsutsui T.W., Corsi A., Calvi L., Kronenberg H.M., Schipani E., Robey P.G., Bianco P.

J. Cell Biol. 167:1113-1122(2004) GeneRIF 19228 · Mapped (2)
The PTH/PTHrP signaling is a major regulator of the ontogeny of the bone marrow and its stromal tissue and of the skeletal stem cell compartment. GeneRIF 19228

MacLean H.E., Kronenberg H.M.

Dev. Growth Differ. 47:59-63(2005) GeneRIF 19228 MGI 97801 · Mapped (4)
Upregulation of PTH/PTHrP receptor mRNA expression in the developing growth plate. GeneRIF 19228

Kobayashi T., Kronenberg H.M., Foley J.

Dev. Dyn. 233:794-803(2005) GeneRIF 19228 MGI 97801 · Mapped (2)
Reduced smooth muscle appears to underlie the majority of nipple deficiencies in mice with lower levels of the Ppr expression GeneRIF 19228

Ortega A., Ramila D., Ardura J.A., Esteban V., Ruiz-Ortega M., Barat A., Gazapo R., Bosch R.J., Esbrit P.

J. Am. Soc. Nephrol. 17:1594-1603(2006) GeneRIF 19228 · Mapped (7)
parathyroid hormone-related peptide by interaction with the PTH1 receptor can increase tubulointerstitial cell survival and seems to act as a proinflammatory and profibrogenic factor in the FA-damaged kidney GeneRIF 19228

Bellido T.

J Musculoskelet Neuronal Interact 6:358-359(2006) GeneRIF 19228 · Mapped (4)
PTHR1 signaling in osteocytes is sufficient for inhibition of Sost expression and leads to a concomitant increase in bone mass. GeneRIF 19228

Pickard B.W., Hodsman A.B., Fraher L.J., Watson P.H.

Endocrinology 148:2282-2289(2007) GeneRIF 19228 · Mapped (5)
PTH1R shuttles from the nucleus to the cytoplasm under normal physiological conditions and that this nuclear-cytoplasmic transport is dependent upon importin-alpha/beta and CRM1 GeneRIF 19228

Ono N., Nakashima K., Schipani E., Hayata T., Ezura Y., Soma K., Kronenberg H.M., Noda M.

J. Biol. Chem. 282:25509-25516(2007) GeneRIF 19228 MGI 97801 · Mapped (5)
constitutive activation of PTH/PTHrP receptor signaling in osteoblastic cells suppresses unloading-induced bone loss specifically through the regulation of osteoclastic activity. GeneRIF 19228

Sneddon W.B., Friedman P.A.

Endocrinology 148:4073-4079(2007) GeneRIF 19228 · Mapped (9)
betaAr-dependent late phase of ERK activation by PTH requires the participation of betaAr2 and PTH1R internalization GeneRIF 19228

Wheeler D., Sneddon W.B.

Endocrine 30:343-352(2006) GeneRIF 19228 · Mapped (3)
PTH(1-34) and PTHrP(7-34) induce a conformational change in the PTH1R that promotes arrestin binding and dissociates NHERF1 from PTH1R internalization. GeneRIF 19228

Okazaki M., Ferrandon S., Vilardaga J.P., Bouxsein M.L., Potts J.T. Jr., Gardella T.J.

Proc. Natl. Acad. Sci. U.S.A. 105:16525-16530(2008) GeneRIF 19228 · Mapped (5)
As compared with PTH(1-34) M-PTH(1-34) bound to R(0) PTHR conformation with higher affinity and induced larger increases in trabecular bone volume and greater increases in cortical bone turnover GeneRIF 19228

Song G.J., Fiaschi-Taesch N., Bisello A.

Mol. Endocrinol. 23:1681-1690(2009) GeneRIF 19228 · Mapped (7)
The regulation of PTH1R expression by endogenous PTHrP and the associated effects on vascular smooth muscle cell proliferation was investigated. GeneRIF 19228

Maeda Y., Schipani E., Densmore M.J., Lanske B.

Bone 46:472-478(2010) GeneRIF 19228 · Mapped (4)
Ihh has both PTHrP-dependent and -independent functions during postnatal endochondral bone development. GeneRIF 19228

Qiu T., Wu X., Zhang F., Clemens T.L., Wan M., Cao X.

Nat. Cell Biol. 12:224-234(2010) GeneRIF 19228 · Mapped (18)
TGFBR2 forms an endocytic complex with PTH1R in response to PTH and regulates signalling by PTH and TGF-beta. TGFBR2 directly phosphorylates the PTH1R cytoplasmic domain which modulates PTH-induced endocytosis of the PTH1R-TGFBR2 complex. GeneRIF 19228

Tawfeek H., Bedi B., Li J.Y., Adams J., Kobayashi T., Weitzmann M.N., Kronenberg H.M., Pacifici R.

PLoS ONE 5:e12290-e12290(2010) GeneRIF 19228 · Mapped (3)
PTH receptor 1 signaling in T cells plays an essential role in parathyroid hormone induced bone loss GeneRIF 19228

Datta N.S., Samra T.A., Mahalingam C.D., Datta T., Abou-Samra A.B.

J. Endocrinol. 207:355-365(2010) GeneRIF 19228 · Mapped (2)
In primary calvarial osteoblasts from 2-week-old phosphorylation-deficient or wild-type mice PTH and PTH-related peptide receptor decreased the levels of phosphorylated extracellular signal-regulated kinases 1/2 and cyclin D1. GeneRIF 19228

Marzan C.V., Kupumbati T.S., Bertran S.P., Samuels T., Leibovitch B., Mira-y-Lopez R., Ossowski L., Farias E.F.

Dev. Biol. 349:125-136(2011) GeneRIF 19228 · Mapped (2)
Adipocyte-PTHR an all-trans retinoic acid-responsive gene was found to be an up-stream regulator of pleiotrophin. GeneRIF 19228

Rhee Y., Allen M.R., Condon K., Lezcano V., Ronda A.C., Galli C., Olivos N., Passeri G., O'Brien C.A., Bivi N. et al.

J. Bone Miner. Res. 26:1035-1046(2011) GeneRIF 19228 · Mapped (8)
PTH receptor signaling influences cortical bone through actions on osteocytes and defines the role of Wnt signaling in PTH receptor action. GeneRIF 19228

Hirai T., Chagin A.S., Kobayashi T., Mackem S., Kronenberg H.M.

Proc. Natl. Acad. Sci. U.S.A. 108:191-196(2011) GeneRIF 19228 MGI 97801 · Mapped (2)
Inactivation of PPR in chondrocytes postnatally leads to accelerated differentiation of chondrocytes followed by disappearance of the growth plate. GeneRIF 19228

Rhee Y., Bivi N., Farrow E., Lezcano V., Plotkin L.I., White K.E., Bellido T.

Bone 49:636-643(2011) GeneRIF 19228 · Mapped (2)
PTH receptor signaling has the potential to modulate the endocrine and auto/paracrine functions of osteocytes by regulating FGF23 through cAMP- and Wnt-dependent mechanisms. GeneRIF 19228

Ono N., Nakashima K., Schipani E., Hayata T., Ezura Y., Soma K., Kronenberg H.M., Noda M.

J. Cell. Physiol. 227:408-415(2012) GeneRIF 19228 · Mapped (2)
These results indicate that constitutive activation of PTH/PTHrP receptor in differentiated osteoblasts enhances bone marrow ablation-induced recruitment proliferation and differentiation of osteoprogenitors. GeneRIF 19228

Datta N.S., Samra T.A., Abou-Samra A.B.

Am. J. Physiol. Endocrinol. Metab. 302:E1183-8(2012) GeneRIF 19228 MGI 97801 · Mapped (3)
PTHR1 phosphorylation does not play a major role in the anabolic action of PTH. GeneRIF 19228