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The Saccharomyces cerevisiae ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis.

Bennett R.A.

Mol. Cell. Biol. 19:1800-1809(1999) SGD S000000115 · Mapped (3)
Cross-species Expression|Function/Process|Fungal Related Genes/Proteins|Mutants/Phenotypes|Non-Fungal Related Genes/Proteins|Protein Sequence Features|RNA Levels and Processing|Strains/Constructs SGD S000000115

Construction and genetic analysis of S. cerevisiae deletants of six novel ORFs from chromosome II.

Malagon F., Aguilera A.

Yeast 15:955-961(1999) SGD S000000115 · Mapped (7)
Mutants/Phenotypes|Strains/Constructs SGD S000000115

Evidence for the involvement of nucleotide excision repair in the removal of abasic sites in yeast.

Torres-Ramos C.A., Johnson R.E., Prakash L., Prakash S.

Mol. Cell. Biol. 20:3522-3528(2000) SGD S000000115 · Mapped (4)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs|Substrates/Ligands/Cofactors SGD S000000115

Base excision repair in yeast and mammals.

Memisoglu A., Samson L.

Mutat. Res. 451:39-51(2000) SGD S000000115 · Mapped (11)
Reviews SGD S000000115

Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III.

Hadi M.Z., Wilson D.M.

Environ. Mol. Mutagen. 36:312-324(2000) SGD S000000115 · Mapped (2)
Fungal Related Genes/Proteins|Non-Fungal Related Genes/Proteins SGD S000000115

3'-phosphodiesterase and 3'-->5' exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage.

Unk I., Haracska L., Prakash S., Prakash L.

Mol. Cell. Biol. 21:1656-1661(2001) SGD S000000115 · Mapped (3)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Protein Sequence Features|Strains/Constructs SGD S000000115

Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases.

Vance J.R., Wilson T.E.

Mol. Cell. Biol. 21:7191-7198(2001) SGD S000000115 · Mapped (7)
Function/Process|Mutants/Phenotypes|Strains/Constructs SGD S000000115

Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases.

Xiao W., Chow B.L., Hanna M., Doetsch P.W.

Mutat. Res. 487:137-147(2001) SGD S000000115 · Mapped (4)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae.

Guillet M., Boiteux S.

EMBO J. 21:2833-2841(2002) SGD S000000115 · Mapped (11)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs|Substrates/Ligands/Cofactors SGD S000000115

Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent.

Monti P., Campomenosi P., Ciribilli Y., Iannone R., Inga A., Shah D., Scott G., Burns P.A., Menichini P., Abbondandolo A. et al.

J. Biol. Chem. 277:28663-28668(2002) SGD S000000115 · Mapped (4)
Function/Process|Genetic Interactions|Mutants/Phenotypes SGD S000000115

Stimulation of 3'-->5' exonuclease and 3'-phosphodiesterase activities of yeast apn2 by proliferating cell nuclear antigen.

Unk I., Haracska L., Gomes X.V., Burgers P.M., Prakash L., Prakash S.

Mol. Cell. Biol. 22:6480-6486(2002) SGD S000000115 · Mapped (3)
Function/Process|Mutants/Phenotypes|Protein Sequence Features|Protein-protein Interactions|Strains/Constructs SGD S000000115

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

Liu C., Pouliot J.J., Nash H.A.

Proc. Natl. Acad. Sci. U.S.A. 99:14970-14975(2002) SGD S000000115 · Mapped (9)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

Disparity between DNA base excision repair in yeast and mammals: translational implications.

Kelley M.R., Kow Y.W., Wilson D.M.

Cancer Res. 63:549-554(2003) SGD S000000115 · Mapped (8)
Non-Fungal Related Genes/Proteins|Reviews SGD S000000115

The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions.

Karumbati A.S., Deshpande R.A., Jilani A., Vance J.R., Ramotar D., Wilson T.E.

J. Biol. Chem. 278:31434-31443(2003) SGD S000000115 · Mapped (7)
Cross-species Expression|Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

Base excision repair activities required for yeast to attain a full chronological life span.

Maclean M.J., Aamodt R., Harris N., Alseth I., Seeberg E., Bjoras M., Piper P.W.

Aging Cell 2:93-104(2003) SGD S000000115 · Mapped (7)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

Origin of endogenous DNA abasic sites in Saccharomyces cerevisiae.

Guillet M., Boiteux S.

Mol. Cell. Biol. 23:8386-8394(2003) SGD S000000115 · Mapped (11)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast.

He F., Li X., Spatrick P., Casillo R., Dong S., Jacobson A.

Mol. Cell 12:1439-1452(2003) SGD S000000115 · UniProtKB (1) · Mapped (70)
Regulation of|Transcription SGD S000000115

Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae.

Boiteux S., Guillet M.

DNA Repair (Amst.) 3:1-12(2004) SGD S000000115 · Mapped (19)
Function/Process|Reviews SGD S000000115

Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae.

Hanna M., Chow B.L., Morey N.J., Jinks-Robertson S., Doetsch P.W., Xiao W.

DNA Repair (Amst.) 3:51-59(2004) SGD S000000115 · Mapped (6)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe.

Ribar B., Izumi T., Mitra S.

Nucleic Acids Res. 32:115-126(2004) SGD S000000115 · UniProtKB (3) · Mapped (3)
Fungal Related Genes/Proteins SGD S000000115

Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair.

Monti P., Iannone R., Campomenosi P., Ciribilli Y., Varadarajan S., Shah D., Menichini P., Gold B., Fronza G.

Biochemistry 43:5592-5599(2004) SGD S000000115 · Mapped (5)
Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

Requirement of yeast Rad1-Rad10 nuclease for the removal of 3'-blocked termini from DNA strand breaks induced by reactive oxygen species.

Guzder S.N., Torres-Ramos C., Johnson R.E., Haracska L., Prakash L., Prakash S.

Genes Dev. 18:2283-2291(2004) SGD S000000115 · Mapped (10)
Function/Process|Genetic Interactions|Mutants/Phenotypes|Strains/Constructs|Substrates/Ligands/Cofactors SGD S000000115

Alpha-anomeric deoxynucleotides, anoxic products of ionizing radiation, are substrates for the endonuclease IV-type AP endonucleases.

Ishchenko A.A., Ide H., Ramotar D., Nevinsky G., Saparbaev M.

Biochemistry 43:15210-15216(2004) SGD S000000115 · Mapped (3)
Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

Rejoining of DNA double-strand breaks as a function of overhang length.

Daley J.M., Wilson T.E.

Mol. Cell. Biol. 25:896-906(2005) SGD S000000115 · Mapped (6)
Function/Process|Mutants/Phenotypes|Techniques and Reagents SGD S000000115

Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae.

Karumbati A.S., Wilson T.E.

Genetics 169:1833-1844(2005) SGD S000000115 · Mapped (9)
Genetic Interactions|Mutants/Phenotypes|Strains/Constructs SGD S000000115

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