Ruano G., Bernene J., Windemuth A., Bower B., Wencker D., Seip R.L., Kocherla M., Holford T.R., Petit W.A., Hanks S.

Clin. Chim. Acta 400:48-55(2009) GAD 586662 GeneRIF 3791 · Mapped (563)
Not Associated with PHARMACOGENOMIC: BMI- Edema rosiglitazone or pioglitazone; GAD 586662 Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) GeneRIF 3791

Tsou R., Isik F.F.

Mol. Cell. Biochem. 224:81-89(2001) GeneRIF 3791 · Mapped (12)
vitronectin increased the presence of all four growth factor receptors and most notably VEGFR-1; in contrast fibrin decreased all four receptors especially FGFR-1 and FGFR-2 GeneRIF 3791

Lamy S., Gingras D., Beliveau R.

Cancer Res. 62:381-385(2002) GeneRIF 3791 · Mapped (3)
green tea catechins are novel inhibitors of VEGFR-2 activity. GeneRIF 3791

Koolwijk P., Peters E., van der Vecht B., Hornig C., Weich H.A., Alitalo K., Hicklin D.J., Wu Y., Witte L., van Hinsbergh V.W.

Angiogenesis 4:53-60(2001) GeneRIF 3791 · Mapped (12)
Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro. GeneRIF 3791

Selheim F., Holmsen H., Vassbotn F.S.

FEBS Lett. 512:107-110(2002) GeneRIF 3791 · Mapped (12)
In this study we give evidence of Flt-1 and KDR receptors in platelets. GeneRIF 3791

Xiang F., Tanaka J., Takahashi J., Fukuda T.

Brain Tumor Pathol 18:67-71(2001) GeneRIF 3791 · Mapped (19)
VEGF Flt1 and Flk1 can be considered as indicators of the malignancy potential of diffusely infiltrating astrocytomas. The expression of VEGF and the two receptors may be affected by the proliferative activity of tumor cells. GeneRIF 3791

Schaefer L.K., Ren Z., Fuller G.N., Schaefer T.S.

Oncogene 21:2058-2065(2002) GeneRIF 3791 · Mapped (3)
Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2) GeneRIF 3791

Kay N.E., Bone N.D., Tschumper R.C., Howell K.H., Geyer S.M., Dewald G.W., Hanson C.A., Jelinek D.F.

Leukemia 16:911-919(2002) GeneRIF 3791 · Mapped (43)
CLL B cells consistently express VEGFR2 mRNA; co-expression of angiogenic molecules and receptors suggest autocrine pathways of stimulation. GeneRIF 3791

Abumiya T., Sasaguri T., Taba Y., Miwa Y., Miyagi M.

Arterioscler. Thromb. Vasc. Biol. 22:907-913(2002) GeneRIF 3791 · Mapped (3)
Expression of vascular endothelial growth factor receptor Flk1/KDR is induced by shear stress through the CT-rich Sp1 binding site. GeneRIF 3791

Ren J., Dong L., Xu C.B., Pan B.R.

World J. Gastroenterol. 8:596-601(2002) GeneRIF 3791 · Mapped (3)
KDR plays a key role in regulating the proliferation of HGCC and HVEC. GeneRIF 3791

McCabe C.J., Boelaert K., Tannahill L.A., Heaney A.P., Stratford A.L., Khaira J.S., Hussain S., Sheppard M.C., Franklyn J.A., Gittoes N.J.

J. Clin. Endocrinol. Metab. 87:4238-4244(2002) GeneRIF 3791 · Mapped (14)
findings implicate altered VEGF and KDR signaling in pituitary tumorigenesis; PTTG stimulation of FGF-2 and VEGF expression in the presence of up-regulated growth factor receptors may account for angiogenic growth and progression of human pituitary tumors GeneRIF 3791

Yang S., Toy K., Ingle G., Zlot C., Williams P.M., Fuh G., Li B., de Vos A., Gerritsen M.E.

Arterioscler. Thromb. Vasc. Biol. 22:1797-1803(2002) GeneRIF 3791 · Mapped (12)
The binding of VEGF to its receptor KDR is necessary and sufficient to induce the gene expression profile induced by VEGF. GeneRIF 3791

Zhang H., Wu J., Meng L., Shou C.C.

World J. Gastroenterol. 8:994-998(2002) GeneRIF 3791 · Mapped (19)
The expression of vascular endothelial growth factor and its receptors KDR and Flt-1 by gastric carcinoma tissues and cell lines was detected to elucidate the molecular mechanism of this growth factor in promoting tumor growth. GeneRIF 3791

Lenton K.

J. Biol. Regul. Homeost. Agents 16:227-232(2002) GeneRIF 3791 · Mapped (3)
VEGFR-2 has a role in regulating angiogenesis-related functions [review] GeneRIF 3791

Elvert G., Kappel A., Heidenreich R., Englmeier U., Lanz S., Acker T., Rauter M., Plate K., Sieweke M., Breier G. et al.

J. Biol. Chem. 278:7520-7530(2003) GeneRIF 3791 · Mapped (26)
transcriptional activation of Flk-1 in endothelial cells requires the interaction between HIF-2alpha and Ets-1 GeneRIF 3791

Kiba A., Yabana N., Shibuya M.

J. Biol. Chem. 278:13453-13461(2003) GeneRIF 3791 · Mapped (10)
A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member VEGF-ENZ-7 is essential for the activation of this protein's signaling. GeneRIF 3791

Urbich C., Stein M., Reisinger K., Kaufmann R., Dimmeler S., Gille J.

FEBS Lett. 535:87-93(2003) GeneRIF 3791 · Mapped (3)
Fluid shear stress induced upregulation requires Sp1 transcription factor binding to specific response elements in the 5' regulatory region GeneRIF 3791

Ho C.L., Sheu L.F., Li C.Y.

Appl. Immunohistochem. Mol. Morphol. 10:316-321(2002) GeneRIF 3791 · Mapped (21)
Staining for the receptors VEGFR-1 and VEGFR-2 was positive in large lymphoid cells in stage IV non-Hodgkin lymphoma. GeneRIF 3791

Zeng H., Zhao D., Yang S., Datta K., Mukhopadhyay D.

J. Biol. Chem. 278:20738-20745(2003) GeneRIF 3791 · Mapped (9)
Gq/11 proteins mediate KDR tyrosine phosphorylation and KDR-mediated HUVEC proliferation through interaction with KDR. GeneRIF 3791

Yilmaz A., Kliche S., Mayr-Beyrle U., Fellbrich G., Waltenberger J.

Biochem. Biophys. Res. Commun. 306:730-736(2003) GeneRIF 3791 · Mapped (3)
These data indicate that activation of vascular endothelial growth factor receptor-2 prevents endothelial cell apoptosis by inhibiting p38 MAP kinase phosphorylation and reducing caspase-3 activity. GeneRIF 3791

Gavin T.P., Robinson C.B., Yeager R.C., England J.A., Nifong L.W., Hickner R.C.

J. Appl. Physiol. 96:19-24(2004) GeneRIF 3791 · Mapped (19)
in humans: 1) VEGF KDR and Flt-1 mRNA are increased by acute systemic exercise; 2) the time course of the VEGF KDR and Flt-1 mRNA responses are different from those previously reported in rats GeneRIF 3791

Zhang R., Xu Y., Ekman N., Wu Z., Wu J., Alitalo K., Min W.

J. Biol. Chem. 278:51267-51276(2003) GeneRIF 3791 · Mapped (9)
TNF induces transactivation between Etk and VEGFR2 and Etk directly activates PI3K-Akt angiogenic signaling independent of VEGF-induced VEGFR2-PI3K-Akt signaling pathway. GeneRIF 3791

Chen J., Dinger B., Jyung R., Stensaas L., Fidone S.

Adv. Exp. Med. Biol. 536:583-591(2003) GeneRIF 3791 · Mapped (17)
Altered expression of vascular endothelial growth factor and FLK-1 receptor in chronically hypoxic carotid body. GeneRIF 3791

El-Obeid A., Sunnuqrut N., Hussain A., Al-Hussein K., Gutierrez M.I., Bhatia K.

Leuk. Res. 28:133-137(2004) GeneRIF 3791 · Mapped (19)
VEGF VEGFR-1 and VEGFR-2 are concomitantly expressed in pre-B ALL cells. Expression of the receptors is limited to the intra-cytoplasmic compartment and may suggest either internalization or a block in trafficking of the receptor to the surface. GeneRIF 3791

Bairey O., Boycov O., Kaganovsky E., Zimra Y., Shaklai M., Rabizadeh E.

Leuk. Res. 28:243-248(2004) GeneRIF 3791 · Mapped (16)
Specific VEGFR2 expression examined in 27 B-CLL samples was positive in 26 of them. The VEGF transduction pathway may be very active in CLL cells. Both its paracrine & autocrine pathways may contribute to their enhanced survival. GeneRIF 3791