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Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.

Vullo D., Nishimori I., Innocenti A., Scozzafava A., Supuran C.T.

Bioorg. Med. Chem. Lett. 17:1336-1340(2007) GeneRIF 763 · Mapped (4)
activators enhanced kcat with no effect on KM favoring the RDS in the catalytic cycle; the activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II. GeneRIF 763

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