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The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.

Katahira J., Straesser K., Podtelejnikov A., Mann M., Jung J.U., Hurt E.

EMBO J. 18:2593-2609(1999) SGD S000001669 · UniProtKB (2) · Mapped (3)
Non-Fungal Related Genes/Proteins SGD S000001669

Nuclear RNA export in yeast.

Strasser K., Hurt E.

FEBS Lett. 452:77-81(1999) SGD S000001669 · Mapped (11)
Reviews SGD S000001669

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export.

Strasser K., Hurt E.

EMBO J. 19:410-420(2000) SGD S000001669 · Mapped (3)
Protein-protein Interactions|Techniques and Reagents|Protein-Nucleic Acid Interactions SGD S000001669

Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast.

Davis C.A., Grate L., Spingola M., Ares M. Jr.

Nucleic Acids Res. 28:1700-1706(2000) SGD S000001669 · UniProtKB (14) · Mapped (82)
RNA Levels and Processing|Fungal Related Genes/Proteins SGD S000001669

Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways.

Vainberg I.E., Dower K., Rosbash M.

Mol. Cell. Biol. 20:3996-4005(2000) SGD S000001669 · UniProtKB (1) · Mapped (5)
Strains/Constructs|Mutants/Phenotypes|Function/Process SGD S000001669

Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export.

Straesser K., Bassler J., Hurt E.C.

J. Cell Biol. 150:695-706(2000) SGD S000001669 · UniProtKB (5) · Mapped (2)
Genetic Interactions|Strains/Constructs|Protein-protein Interactions|Mutants/Phenotypes|Function/Process SGD S000001669

Factors affecting nuclear export of the 60S ribosomal subunit in vivo.

Stage-Zimmermann T., Schmidt U., Silver P.A.

Mol. Biol. Cell 11:3777-3789(2000) SGD S000001669 · UniProtKB (6) · Mapped (36)
Strains/Constructs|Mutants/Phenotypes|Substrates/Ligands/Cofactors|Function/Process SGD S000001669

The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex.

Strawn L.A., Shen T.X., Wente S.R.

J. Biol. Chem. 276:6445-6452(2001) SGD S000001669 · UniProtKB (2) · Mapped (6)
Strains/Constructs|Cellular Location|Function/Process SGD S000001669

A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription.

Jensen T.H., Patricio K., McCarthy T., Rosbash M.

Mol. Cell 7:887-898(2001) SGD S000001669 · UniProtKB (1) · Mapped (7)
Substrates/Ligands/Cofactors|Function/Process SGD S000001669

Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.

Straesser K., Hurt E.

Nature 413:648-652(2001) SGD S000001669 · UniProtKB (1) · Mapped (3)
Cellular Location|Protein-protein Interactions SGD S000001669

A conserved mRNA export machinery coupled to pre-mRNA splicing.

Reed R., Hurt E.

Cell 108:523-531(2002) SGD S000001669 · Mapped (10)
Reviews SGD S000001669

The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability.

Jimeno S., Rondon A.G., Luna R., Aguilera A.

EMBO J. 21:3526-3535(2002) SGD S000001669 · UniProtKB (5) · Mapped (3)
Strains/Constructs|Mutants/Phenotypes|Fungal Related Genes/Proteins|Function/Process SGD S000001669

60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm.

Nissan T.A., Bassler J., Petfalski E., Tollervey D., Hurt E.

EMBO J. 21:5539-5547(2002) SGD S000001669 · UniProtKB (5) · Mapped (7)
Protein-protein Interactions|Function/Process SGD S000001669

The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores.

Fischer T., Straesser K., Racz A., Rodriguez-Navarro S., Oppizzi M., Ihrig P., Lechner J., Hurt E.

EMBO J. 21:5843-5852(2002) SGD S000001669 · UniProtKB (3) · Mapped (4)
Protein-protein Interactions|Function/Process SGD S000001669

Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex.

Lei E.P., Stern C.A., Fahrenkrog B., Krebber H., Moy T.I., Aebi U., Silver P.A.

Mol. Biol. Cell 14:836-847(2003) SGD S000001669 · Mapped (3)
Genetic Interactions|Strains/Constructs|Protein-protein Interactions|Mutants/Phenotypes|Function/Process SGD S000001669

Early formation of mRNP: license for export or quality control?

Jensen T.H., Dower K., Libri D., Rosbash M.

Mol. Cell 11:1129-1138(2003) SGD S000001669 · Mapped (18)
Reviews SGD S000001669

The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export.

Senay C., Ferrari P., Rocher C., Rieger K.J., Winter J., Platel D., Bourne Y.

J. Biol. Chem. 278:48395-48403(2003) SGD S000001669 · UniProtKB (2) · Mapped (3)
Fungal Related Genes/Proteins SGD S000001669

Directing mRNA export.

Izaurralde E.

Nat. Struct. Mol. Biol. 11:210-212(2004) SGD S000001669 · Mapped (4)
Reviews SGD S000001669

Ribosome synthesis meets the cell cycle.

Dez C., Tollervey D.

Curr. Opin. Microbiol. 7:631-637(2004) SGD S000001669 · Mapped (113)
Reviews SGD S000001669

Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex.

Mans B.J., Anantharaman V., Aravind L., Koonin E.V.

Cell Cycle 3:1612-1637(2004) SGD S000001669 · Mapped (54)
Non-Fungal Related Genes/Proteins|Fungal Related Genes/Proteins SGD S000001669

Emergence of species-specific transporters during evolution of the hemiascomycete phylum.

De Hertogh B., Hancy F., Goffeau A., Baret P.V.

Genetics 172:771-781(2006) SGD S000001669 · Mapped (489)
Fungal Related Genes/Proteins|Evolution SGD S000001669

Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway.

Panse V.G., Kressler D., Pauli A., Petfalski E., Gnadig M., Tollervey D., Hurt E.

Traffic 7:1311-1321(2006) SGD S000001669 · Mapped (28)
Genetic Interactions|Strains/Constructs|Mutants/Phenotypes SGD S000001669

Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription.

Gwizdek C., Iglesias N., Rodriguez M.S., Ossareh-Nazari B., Hobeika M., Divita G., Stutz F., Dargemont C.

Proc. Natl. Acad. Sci. U.S.A. 103:16376-16381(2006) SGD S000001669 · Mapped (9)
Protein Physical Properties|Strains/Constructs|Protein-protein Interactions SGD S000001669

Ratcheting mRNA out of the nucleus.

Stewart M.

Mol. Cell 25:327-330(2007) SGD S000001669 · Mapped (4)
Reviews SGD S000001669

Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.

Yao W., Roser D., Kohler A., Bradatsch B., Bassler J., Hurt E.

Mol. Cell 26:51-62(2007) SGD S000001669 · Mapped (3)
Strains/Constructs|Protein Sequence Features|Function/Process|Genetic Interactions|Mutants/Phenotypes|Protein-protein Interactions|Non-Fungal Related Genes/Proteins|Protein/Nucleic Acid Structure|Protein-Nucleic Acid Interactions SGD S000001669

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